RAS Activation

While inactive, tyrosine kinase exists as

The binding of the ligand causes the ....?... of tyrosine kinase

The structural change of tyrosine kinase causes

What allows tyrosin kinase to become fully active?

When the protein is fully activation, which protein is phosphorylated?

This phosphorylation provides a docking site for which protein?

What does the activation of RAS require?

Which part of GRB2 binds to GEF?

The SH2 subunit of GRB2 binds where?

Why doesn't GRB2 bind to GEF all the time?

Adaptor Protein

What aa-rich domain does the SH3 domain of GRB2 bind to?

Where is inactive RAS found in a cell?

What does GEF stand for?

Why does GEF binding activate RAS?

What is the main function of active RAS?

How is RAS deactivated?

How long is RAS active for (in general)

How does GEF activate RAS?

Name the two aa that hold the RAS switch closed

What is the first protein RAS activates?

14-3-3 protein

Phosphorylation of what aa holds RAF inactive?

The binding of RAS to RAF causes what to be displaced?

RAS binding causes what to be phosphorylated?

RAS binding causes what to be dephosphorylated?

Once RAF has been unfolded, it phosphorylates

MAPK is phosphorylated by

MEK is unusual because

Function of MPK

How is MAPK activated?

Name the P protein activated by MAPK

p90rsk activates

MEK stands for...

MEK stands for

How does MEK phosphorylated MAPK?

p90rsk is sensitive to...

PP1G stands for