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Erstellt von Sophie Obayashi
vor fast 9 Jahre
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major neurotransmitter in excitotoxicity
permeability of glutamate?
where is glutamate synthesized?
glutamate synthesis process
VGLUT
glutamine synthetase
glutaminase
EAAT
EAA receptor category comparison
ionotropic EAA receptor subtypes
metabotropic EAA receptor subtypes
NMDA receptor characteristics
excitotoxins
endogenous excitotoxin examples
exogenous excitotoxin examples
Neuroendocrinopathies; glutamate & MSG
counter mechanisms, target locations, symptoms, other
neurolathyrism; BOAA
counter mechanisms, target locations, symptoms, other
APD complex; BMAA
counter mechanisms, target locations, symptoms, other
Domoic acid (seafood poisoning)
1. misfolding: changes in protein structure (i.e. harsh conditions, genetic mutation) prevent proper alpha helix/beta sheets OR change structure/decrease activity
2. oligomerization: chemical process that converts monomers to macromolecular complexes via polymerization, rearranges/changes structure
3. fibrilization: changes in quaternary protein structure, proteins acquire distinct physical properties - cross-beta structure, decreased solubility, increased stability against proteases
4. inclusion formation and deposition: aggregation and sequestration of fibrils, incorporation of other proteins and molecules, post-translational modifications (e.g. methylation) increases stability against degradation/proteases