University Fundamentals of Medicine (Molecular Biology and Genetics) Karteikarten am DNA structure and replication, erstellt von Ifeoma Ezepue am 05/11/2015.
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Erstellt von Ifeoma Ezepue
vor etwa 9 Jahre
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Schließen
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Erstellt von Ifeoma Ezepue
vor etwa 9 Jahre
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Why is DNA important?
What is a DNA nucleotide made out of?
What can be said about the strands of DNA?
What is the 5' end?
What is the 3' end?
Explain the compaction of DNA
Describe the differences in compaction at interphase and metaphase
What is the role of linker histones?
Why are histones abundant in the nucleus?
What are core histones?
With chromosomes in interphase nucleus what do you see?
What is the difference between the sense and anti-sense strand?
What is the difference between the lagging and leading strand?
Explain the process of DNA replication in terms of leading and lagging strands
Explain the role of DNA topoisomerases
What targets topoisomerases? What is the result of this?
Some antibiotics interfere with DNA replication in bacteria. Give some examples
There are three ways to repair single strand defects. Explain base excision repair
There are three ways to repair single strand defects. Explain nucleotide excision repair
What is a pyrimidine dimer and what is it caused by?
What is the major concern with double strand breaks?
Double strand breaks can be joined by end-joining. Explain how non-homologous end-joining works
Double strand breaks can be joined by end-joining. Explain how homologous end-joining works
Draw a table depicting some examples of inherited DNA repair defects. Include name, phenotype and affected processes
