Which step of metastasis is the easiest?
Travel in the bloodstream
Escape from parental tissue
Colonisation of new tumor sitee
What is special about virus induced cancers?
They skip the transformed cell step
They never get past the transformed cell step
RNA viruses require what to be infectious?
Reverse Transcriptase
DNA Polymerase
DNA Helicase
Why is viral integration so dangerous?
It makes the disruption of important genes more likely
It tampers with translation/transcription machinery
It prevents proteins from folding properly
Can viruses pick up human genes, and would it be dangerous?
Yes- they would cause over-expression of the gene as they replicated
Yes- they would potentially gain the ability to better survive inside the cell
No
If a virus picked up only part of a gene, is this dangerous?
Potentially more so than a whole one- a protein that worked but had no control domains would be very dangerous
Yes, but less than a whole one- the protein would not function as well
No- viruses cannot pick up genes
No- the protein wouldn't function
If Src was to be overproduced, what would the effect be?
Debundling of vinalin
Debundling of laminin
Cells release surface and degenerate further
