Skeletal Neuromuscular Junction - James Hodge

What are the two sub categories of ACh receptors

Where are mAChR found and how are they structured?

What are the two subtypes of nAChRs?

Describe the structure of the NMJ nAChR

What is the structure of neuronal nAChRs?

Where are neuronal nAChRs found in the PNS?

Where are neuronal nAChRs found in the CNS?

Where is the ligand binding site on the nAChR?

Are nAChRs selective?

What roughly is the RMP for nAChR usually?

How do K+ and Na+ currents relate at rest through an nAChR?

Define endplate potential?

What are the precursors to acetylcholine?

Which enzyme synthesises Acetylcholine?

Which enzyme breaks down acetylcholine

What percentage of acetate and choline are recaptured?

Which two drugs act presynaptically to prevent exocytosis?

Give an example of a non-depolarising blocker

What effect on end plate current does a non-depolarising blocker have?

What would you expect to see with inhibition of neuromuscular transmission?

What would be the expected order of muscle relaxation?

What effect to non-depolarising blockers have on pain perception and consciousness?

What are the benefits of non-depolarising blockers?

What is a common side effect in non-depolarising blockers?

Give an example of a depolarising blocker

Why is the desensitisation of nAChR a slow process?

What are the four key differences in depolarising v. non-depolarinsing drugs?
(fasciculations, post-op,reversibility)

What effect does prolonged presence of an anticholinesterase cause?

What are the two sites on acetycholinesterases?

Which part of the acetycholine molecule is attracted to which part of the acetycholinesterase?

What are the main causes of myasenthia gravis?

What is the main underlying problem with myasthenia gravis

What are the symptoms of myasthenia?

How do you test for myasthenia gravis?

What 3 anticholinesterases do you use to treat myasthenia gravis? Where do they act?

Which anticholinesterase would you give to reverse a non-depolarising block after surgery?

Which two anticholinesterases can be used to treat alzheimers?

Give an example of two organophosphates?
Why are they so damaging to people?

Why does myasthenia gravis cause a rightward shift in a concentration response curve for a given amount of endogenous agonist?

Why do medium lasting anticholinesterases last longer than short duration?

Why is edrophonium short acting?

Why are irreversible blocks irreversible?

What are the side effects of anticholinesterase intoxication at the:

Eye

Heart

Lung

GI Tract

Glands

NMJ

CNS

How can you reverse/help the effects of anticholinesterase poisoning?

What drug can you use to combat the effects of irreversible anticholinesterases?