Drug Abuse and Drug Addiction - L1

Define Drug Abuse

Drug addiction

Define stimulants - give four examples.

What do depressants do? Give 2 main classes.

What is used to treat opiate addiction?

What do hallucinogens do? What kind of effect do they have? What do they target?

What is ketamine, where does it act?

Why do people take drugs?

How do animals learn behaviours and what can this be exploited by?

What kinds of dependence are there?

Why do physical withdrawal symptoms occur?

Which system does alcohol act at?

What are the important neurotransmitters involved in addiction?

What effects does LSD have on 5-HT receptors? (2)

Which receptor does LSD act on? What does it act as?

What do drugs acting on the glutamate system cause?

What effect do 5-HT2a agonists have on glutamate levels, where especially? What effect does this lead to?

What is the key pathway in reward?

What is dopamine released in response to?

What does the rate of onset of a drug depend on?

How does onset of drug effect the euphoric feeling?

What are the parts of the brain involved in drug addiction? What happens to these pathways?

What other part of the brain is activated in addiction? What effect does this have?

Where does .... act on the reward pathway?

Stimulants (cocaine and amphetamine) (2)

Opiates and alcohol?

Nicotine?

Cannabinoids?

PCP/Ketamine