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1-the following may be used to assess drug efficacy in the graded dose – response curve :
A- slope of the curve
B- ED50
c- Emax
D- A&C
2-atropine is used as pre-anesthetic medication due to all the following except :
it decreases blood pressure
it induces bronchodilatation & stimulates respiration
it decreases vomiting
it blocks the cardiac muscarinic receptors
3- the following is NOT an adverse effect of cholinomimetics :
Bronchospasm
Diarrhea
Tachycardia
aggravate peptic ulcer
4-treatment of atropine poisoning does not include:
A- gastric lavage
B- neostigmine
C- diazepam
D- cooling blankets
5-Important factor\s which may govern diffusion of drugs across cell membranes :
A- pKa value of the drug.
B- pH of the medium.
C- lipid solubility of the drug.
D- all of the above.
6- at the end of operation , the action of neuromuscular blocker is reversed by :
a- atropine preceded by neostigmine
b- neostigmine preceded by atropine
c- atropine preceded by physostigmine
d- physostigmine preceded by atropine
7-clearance is useful in calculation of :
a-maintenance doce
b-loading dose
c- t 1\2
d -a&c
8-Propranolol is contraindicated in all of the following cases except:
A) Open angle glucoma
B) Diabetes Mellitus
C) Thyrotoxicosis
D) Bronchial asthma
9-which of the following beta blockers is suitable in patient with open angle glaucoma ?
a- betoxolol
b- bisorolol
c- pindolol
propranolol
10- Which of the following drugs inhibit the release of NE :
A) Guanethedine
B) Reserpine
C) Metyrosine
D) Non of the above
11- patient with history of sulfonamide hypersesitivity , suffered head injury with brain edema , which of the following combinations is best for him ?
a- acetazolamide & mannitol
b- metolazone & mannitol
c- dexamethazone & frusemide
d- dexamethazone & mannitol
12- furosemide is useful for treatment of the following conditions except :
a-hypercalcuria
b- hypertensive encephalopathy
c- acute renal failure
d- acute pulmonary edema
13-antihypertensive effect of frusemide is decreased by :
a- NSAIDs
b- spironolactone
c- corticosteroids
d- a& c
14-The following diuretics are secreted through the renal tubules except:
a- Triamterene
b- Spironolactone
c-Hydrochlorothiazide
d- Frusemide
15- uses of acetazolamide include all the following except :
a- urinary calcium phosphate stones
b- emphysema & high altitude sickness
c- to alkalinize urine for excretion of salicylates
d- to alkalinize urine for excretion of barbiturates
16- ACEIs have the following advantages except :
a- they induce no change in heart rate
b- they preserve renal function
c- they induce no change in k level
d- they reduce cardiovascular mortality
17- A nitric oxide donor that may induce cyanide toxicity :
a- nitrates
b- nitroprusside
c- nicardipine
d- A&B
18- A hypertensive patient with angina should not be given :
a-pindolol
b- bisoprolol
c- amlodipine
d- metoprolol
19- used with vasodilators to counteract the reflex tachycardia :
a- captopril
b- methyldopa
c- bisoprolol
d- pindolol
20- in congestive heart failure , the following drugs act directly on the myocardium increasing the cardic output except :
b- digoxin
c- dopamine
d- dobutamine
21-A drug used to terminate an attack of paroxysmal supraventricular tachycardia but may induce bronchospasm :
a- lidocaine
b-adenosine
c- verapamil
d- diltiazem
22- all the following decrease mortality in HF except :
a- metoprolol
b-bisoprolol
c- carvedilol
23-A pregnant asthmatic hypertensive patient should NOT receive :
a- candesartan
b- labetalol
c- thiazides
d- all the above
24- In management of digitalis induced bradyarrhythmia the following is (are) true :
a- KCL should not be administered
b- atropine should be administered
c- lidocaine should be administered
25- candesartan has the following advantages over lisinopril EXCEPT :
a- no bradykinin production thus no risk of cough
b- antagonizes AG II formed by ACE & non- ACE pathways
c- no hormonal "escape " seen with prolonged ACEIs therapy
d- less teratogenic
26- which one of the following is adirect inhibitor of factor Xa ?
a- dalteparin
b- heparin
c- rivaroxaban
d- fondaparinux
27- all the following decrease the action of warfarin except :
a- erythromycin
b- vit K
c- oral contraceptives
d- rifampicin
28- which of the following is long acting & can be given by single I.V bolus :
a- streptokinase
b- tenecteplase
c- urokinase
d- all of the above
29- folic acid deficiency is associated with the use of :
a- methotrexate
b- trimethoprim
c- metronidazole
30- given that normal Hb=14gm/ dl , which of the following the following is the parentral iron dose required to correct anemia & replenish stores for a female with Hb=4 gm / dl :
a- 100 gm
b- 10 gm
c- 5 gm
d- 2.5 gm