In Burkitt's, EBNA1 is the only gene product expressed
EBNA1 & EBNA2 are the only gene products expressed in all EBV associated malignancies
What is the role of EBNA1?
Binds to EBNA1 origin
Binds to EBNA1 promoter
Mediates EBV genome synthesis
What is the other role of EBNA1?
Viral transcription factor for latent genes required for maintaining proliferation
Viral transcription factor for latent genes required for maintaining latency
Viral transcription factor for latent genes required for initiating proliferation
EBNA1 can bind to host cells and cause what?
Oncogenesis
Apoptosis
Necrosis
Downregulation of EBNA causes proliferation
EBNA1 has aptotic effects
