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Erstellt von Emma Allde
vor etwa 8 Jahre
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What are the 3 forms of induced mutation and what are their main mechanisms of action
What is UV-C (180-290 nm)
What is UV-B (290-320 nm)
What is damage causes by UV irradiation
What is Nitrous acid an example of
What is Alkylating agents an example of
What are Free radicals examples of (strand breaks and base modification)
What are free radicals
What is Xeroderma pigmentosum (XP)
What are the symptoms of Xeroderma pigmentosum (XP)
What are the general characteristics of cancer cells
How many mutations are sufficient to turn healthy somatic cell to a cancerous cell
To the point where DNA polymerase will not recognise mutated strand
How many (%) of human primary tumours test positive for telomerase activity
What kind of point mutations are there (4)
What is a silent mutation
What is a missense (non-synonymous)
What is a nonsense mutation
What are indels (mutations)
What kind of indels exist (2)
loss of 508th codon in CFTR > cystic fibrosis when homozygous is an example of what kind of mutation
Which mutation results in frame shifts resulting in non-native polypeptides which can be catastrophic
What is Huntington's disease an example of
What happens as a result of loss of 32bp in CCR5
What is CCR5
What is cri du chat
What is Chronic myelogenous leukaemia (CML)
What are the 3 examples of spontaneous mutation
What is replication slippage
What is deamination
What causes human immunodeficiency virus (HIV)
What do CD4 T cells do
What do the high mutations rate of HIV genome result in
What do early HIV symptoms resemble
What does Azidothymidine (AZT) do
What is the main issue with Azidothymidine (AZT)
What is the HIV mutation rate
What is the typical mutation rate of a eukaryotic genome
What is reverse transcriptase
What features of reverse transcriptase make it so lethal (2)
What is Acute myeloid leukaemia
What do all forms of AML have in common
Which genes are mutated in AML (3)