B Cells recognise native antigens, T cells recognise processed antigens
Which of the following are NOT professional antigen presenting cells?
Neutrophils
Macrophages
Dendritic cells
CD8 T-cells recognise which MHC complex?
MHCI
MHCII
CD4 is for the detection of virally infected cells
CD4 cells recognise MHCII, which uses which Antigen processing system?
Endosomal
Endogenous
Endomal
Cells with MHCI present using the endogenous AP system
T- cells cannot recognise soluble, native antigens
Put the following steps in the correct order- A (Antigen-MHC Complex Formation), B (Uptake), C (Presentation) and D (Degredation
B-D-A-C
A-B-D-C
A-C-B-D
Which of the following definitions is incorrect?
Uptake- picking up of the antigen from surrounding fluid
Degredation- total digestion of the antigen
Presentation- movement of the complex to the cell surface
Endosomal Pathway- What is it for?
Processing of extracellular antigens picked up by antigen presenting cells
Processing of cytosolic viral antigens
Endosomal Pathway- Uses the MHCI complex
Endosomal Pathway- The extracellular antigen is picked up by phagocytosis
Endosomal Pathway- How is picking up of the antigen mediated?
Receptor mediated
Compliment mediated
Hormone mediated
Endosomal Pathway- The antigen containing endosome only binds to the MCHII containing endosome after partial digestion
Endosomal Pathway- How is the active site of MHCII covered in the cell?
Covered by an invariant 'cap'
The two parts are connect by a subunit that must be removed
Receptor surface is bound to the endosome envelope
Endosomal Pathway- The cover of the MHC complex is called a CLIP
Endosomal Pathway- How is the processed antigen added to the MHCII complex?
Acessory proteins swap the CLIP for the peptide when the two vesicles fuse
Acessory proteins remove the MHCII from the envelope when the two vesicles fuse
Acessory proteins remove the subunit connecting the two halves when the two vesicles fuse
Endogenous Pathway- Main use is for what?
Viral antigen processing
Professional pesentation of antigens
Endogenous Pathway uses MHCII
Endogenous Pathway- How are cytosolic antigens processed?
By the TCR
By MHCI
By cytosolic proteases
Endogenous Pathway- Digested peptides are moved into the Golgi by what?
Transporter Associated with Antigen Processing (TAP 1&2)
Transporter Associated with Antigen Digestion (TAD 1&2)
Transporter Associated with Antigen Presentation (TAP 1&2)
In the Golgi the processed peptide is bound to MHCI and they complex is loaded into a vesicle for transport to the cell membrane
