Which options are primary lymphoid organs?
Thymus
Bone marrow
Spleen
Peyer's patches
MALT
Which options are secondary lymphoid organs?
Lymph nodes
Dendritic cells are derived from lymphoid and myeloid precursors.
Platelets are derived directly from pluripotent stem cells.
Which options do not express MHC Class 1?
Red blood cells
Platelets
Neutrophils
B cells
T cells
Naive B cells are derived from the
CD4+ T cells recognise
MHC Class 1
MHC Class 2
CD8+ T cells recognise
CD16 and CD56 are both found on
NK cells
Macrophages
All leukocytes express
CD45
CD19
CD68
CD59
The most abundant leukocyte in circulation are...
CD8+ T cells
Monocytes and Macrophages help to produce components involved in the complement system
Macrophages are able to present antigens on their surface
Monocytes have CD.....
14
56
16
15
During phagocytosis, fusion of the lysosome and phagosome leads to production of...
Phagolysosome
Early endosome
Endophagosome
Which granulocytes have major basic protein in their granules?
Eosinophils
Basophils
Which granulocytes have lactoferrin in their granules?
Which granulocytes do not have histamine in their granules?
Which granulocytes have chondroitin sulphate in their granules?
Which of these are reactive oxygen species?
Hypochlorous acid
Hydrogen peroxide
Superoxide
Water
The only antimicrobial peptides that macrophages use are...
Cathelicidins
Azurocidin
Defensins
Histatins
Acidification by neutrophils or macrophages is...
Bacteriocidal
Bacteriostatic
Can be both
Both macrophages and neutrophils produce ROS's.
Both macrophages and neutrophils produce NETs.
The most potent antigen present cell is...
Dendritic cells
Monocytes
Label the features of platelets
Most T cells are...
CD4 positive but CD8 negative
CD4 positive and CD8 positive
CD8 positive but CD4 negative
Which cytokine results in a T cell receptor being produced on an immature T cell?
IL-7
IL-10
GM-CSF
TNF-a
Self molecules are said to induce...
Tolerance
Multi-specificity
Immunogenicity
What is negative selection?
T cells with a high affinity for self antigens are killed by apoptosis
T cells with a high avidity for self antigens are killed by apoptosis
T cells with a low affinity for self antigens are killed by apoptosis
T cells with a low affinity for self antigens are allowed to mature
What is positive selection?
T cells with a high affinity for self antigens are allowed to mature
T cells with a high affinity for self antigens are killed off by apoptosis
T cells with a low affinity for self antigens are killed off by apoptosis
The majority of T cells do not make it through negative selection.
T cells without any stimulation also die off.
What CD do T regulatory cells have?
4
19
8
Which cells do TH1 helper cells activate?
Any nucleated cell
Stromal cells
Which cells do TH2 helper cells activate?
Which cells do TH17 helper cells activate?
What is the main effect of T reg cells?
Recruiting neutrophils
Activating macrophages
Triggering B cell proliferation and antibody secretion
Inhibition of immune response
What is the main effect of TH2 cells?
What is the main effect of TH1 cells?
What is the main effect of TH17 cells?
Which cytokine(s) tend to be released by TH17 cells?
IL-17
TGF-beta
Which cytokine(s) tend to be released by TH1 cells?
IFN-gamma
Which cytokine(s) tend to be released by TH2 cells?
IL-4
TNF-b
PGD2
Which cytokine(s) tend to be released by CD8+ cells?
TGF-b
What feature on T cells helps to induce proliferation B cells?
CD40
CD40 Ligand
mIgM
B cells have complement receptors.
As well as perforin and granzyme to kill target cells, NK cells have...
NK Cytotoxic factor
Major basic protein
Lyophosphatase
Interferon gamma is produced by NK cells - what is its function?
Activate phagocytes
Activates B cells
Induces proliferation of T cells
NK cells have a T cell receptor.
T cells are the most abundant lymphocytes.
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