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Volume of
Distribution
Vd
Vd
Lipo/hydro
PHILIC
Loading dose
calc
Clearance:
Directly vs
Inversely
Elimination
Half-Life
Half life
vs
Half time
Like
Dissolves
Like
Ion Trapping
Plasma Protein
Binding
Plasma Concen:
Albumin
& Alpha-1 acid
glycoprotein
Plasma Protein
Binding & Vd
Metabolism
Phases
(3)
Perfusion dependent
vs
Capacity dependent
Extraction Ratio
formula
ER > 0.7
ER < 0.3
LOW ER
Drugs
P450 Enzymes:
Inducers vs
Inhibitors
Other enzymes
Polarity &
Elimination
Transport drugs
to urine:
Urine pH
Reabsorption &
Excretion
Metabolism in the
Plasma
Difference between:
Kinetics
Biophasics
Dynamics
Dose Response
Curve:
Efficacy & Potency
Dose Response
Curve:
Affinity for receptor
Agonists
Partial Agonists
Antagonists
Inverse Agonists
(graph)
Drugs administered
together
Therapeutic Index
ED 50
LD 50
Chirality
Enantiomerism
Enantiomerism
in Anesthesia
