PET and fMRI

What did James 1890 hypothesis about MRI?

Describe how PET works.

suggest why after the injection of an isotopic trace it will build up in areas of high metabolic activity.

Give the isotopic trace used to detect tumors and why it is effective.

Explain the subtractive scanning in relation to a PET scan, and give reasons why it is important.

why can a PET scan be used to detect cancers?

How come we use L-DOPAs isotopic equivalent (F18-DOPA) instead of dopamine when doing PET scans?

What happens to methamphetamine abusers dopamine transporters? what effect might this have one them?

What is the main use of MRI? How does this differ from fMRI?

Describe how an MRI machine works

Explain the importance of H+ and iron in MRI

What is the actual signal we measure from an fMRI? Why does this give us information about neural activity?

fMRI has a good spatial resolution, but what is this spatial resolution dependant on? Give problems with increasing this to extreme levels.

Give a study which has shown fMRI combined with galvanic vestibular stimulation is a safe technique to use

Give some applications of MRI

Give a study which has used MRI to assess changes in brain structure as a result of learning.

What kind of fMRI is affected by blood oxygenation? What is deoxygenated blood associated with on an fMRI scan?

Give a study which combined fMRI and MRI to look at difference in memory capacity. What did they find?

Suggest how you might go about looking at why when we tickle ourselves we feel it less, with regards to brain areas. Give the study which has already done this and what he found.