Th cells are activated by MHCII and a co-stimulation signal
CD4 T-cells are a major source of cytokines after activation
Which of the following is a major autokrine stimulator for clonal proliferation of Th cells?
IL2
IL3
IL4
Which of the following is not a factor in CD4 cell polarisation?
Infection type (I.e. does the microenvironment indicate a fungus, a virus?)
Amount of antigen/binding strength of antigen
'Dose' of infection
Production of cytokines by one type of Th cell, causes the polaristion of native Th cells to the type that produced the cytokines (i.e. Th1 produced cytokines encourage Th1 conversion)
During non-infection, which cell is predominant?
Th1
Th2
Neither, till infection tips the balance
Name ways in which the activity of cytokines can be controlled
Short half life- only effect nearby cells
Specific receptors prevent unwanted signalling
High concentrations needed for cell activation
Active destruction by incorrect cells
