In which setting is biofilm infection common?
Hospitals
Community Centers
Nursing Homes
Why are biofilm infections so problematic?
They're localised
Resist phagocytosis
Tend to be multi-drug resistant
Have heterogenous populations
Which bacteria cause Infective Endocarditis?
Streptococci
Staphylococci
E.Coli
Put the following on order of Endocarditis Infection- A- Initial damage provides surface for binding B- Lesions form on the heart valve C-A bundle of bacteria, plateles and fibrin forms
A-C-B
A-B-C
C-A-B
Name four reasons why biofilm bacteria are difficult to diagnose
They are localised in one body part
The bacteria are encased in a matrix and difficult to detect
The bacteria are surface related
The bacteria are usually resistant to anti-biotics
It is thought the barrier properties of EPS help resistance to antibiotics in biofilm bacteria
Which of the following are possible explainations for biofilm resistance to antibiotics?
Starved, slow growing bacteria in the centre will take up less antibiotics
There are more likely to be subpopulations of resistant bacteria
Bacteria can assist each other in removing bacteria from a biofilm
Biofilm bacteria are immune to drugs that cannot penetrate the cell wall
