1

2

3

Solid state

Particle size

Molecular weight

Chemical structure

To increase the solubility

To mask bitter tastes

To increase the viscosity

To decrease the viscosity

None of the above

The viscosity would be infinite

The settling rate will be very high

The settling rate would be zero

The particle size would approach colloidal dimensions

Density

Viscosity

Dielectric constant

Flocculation with formulation of loosely bound aggregates

Flocculation with formulation of strongly bound aggregates

Formation of loose sediment

Ease of mixing with relatively mild shaking of the container

Lower viscosity on standing to prevent settling

Caking of needle shaped particles

Only for acute usage

Only for antibiotics

Never

You can save the effort and advise the patient they must wait until you can order the
commercial dosage form

If a commercial liquid dosage form isn’t available, it may indicate a potential chemical
stability problem

If a commercial liquid dosage form isn’t available, it may indicate a potential physical
stability problem

Both B and C

1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.

1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH

1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.

All of the above

Dispersed phase tends to form aggregates of globules on standing

Aggregates of the dispersed phase may be re-dispersed by shaking

Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase

All or part of the liquid in the dispersed phase separates to form a distinct layer

In the refrigerator

At room temperature

In the freezer

72 and 28% respectively

28 and 72% respectively

None of the above

Two phase gel in which the gel mass does not consists of floccules of small distinct particles

One phase gel in which the gel mass consists of floccules of small distinct particles

Two phase gel in which the gel mass consist of floccules of small distinct particles

Much smaller than typical molecule dimensions

Much larger than typical molecule dimensions

The same or smaller than typical molecule dimensions

A measurable increase in volume of Gel

A non-measurable change in the volume of Gel

A measureable decrease in volume of Gel

A and B

B and C

To prevent drying of Gel

Sweetner

Antioxidant

Particle size >50μm

Particle size <50 μm

Particle size <1μm

None of above

Preservative

Glycerin

Alcohol

None of the above

Creaming

Coalescence of droplets

Flocculation

None of the above

O/W

W/O

None of the above

10

100

1000

To facilitate transport and ease of administration

Maintain the stability of API

Improve patient compliance