Select the possible direct causes of pancreatitis:
Smoking
Alcohol abuse
Fibre rich diet
Gallstones
Abdominal trauma
Gallstones are the most common cause of pancreatitis.
Which of the following are involved in the pathophysiology of alcohol induced pancreatitis?
Ethanol metabolism produces toxic metabolites
Diversion of bile into the pancreatic duct
Leakage of pancreatic enzymes
Disruption of pancreatic acinar cells
Which of the following are involved in pathophysiology of pancreatitis resulting from gallstones?
Biliary tract obstruction
Stones move into the common bile duct (CBD)
Premature activation of enzymes
Auto-digestion
Pancreatic inflammatory response involves and leads to which of the following?
Pancreatic acinar cells synthesise trypsin.
Trypsin converts kallikrein to bradykinin.
Bradykinin increases capillary permeability leading to oedema.
Interstitial oedema within pancreatic tissue can result in necrosis.
