M7.10

Name 4 chlormethine analogues

what is the effect of DNA alkylation?

what is the preferential tautomer for guanine and alkylated guanine?

Difference in H bonding in guanine and alkylated guanine

name the most commonly used alkylating agent

what is cyclophosphamide?

how is it administered

what is the by-product of the reaction of cyclophosphamide that is associated with toxicity?

what is the structure of the alkylating agent that arises upon activation of pro drug cyclophosphamide

name to nitrosoureas alkylating anticancer agents

what is the alkylating agent that arises from the decomposition of nitrosoureas prodrugs?

what is the anticancer effect of nitrosoureas alkylating agents

what is the synthetic compound used as an anticancer agent that causes interstrand crosslinking via Sn2 reaction?

write down the mechanism for busulfan reacting with DNA

name the naturally occurring alkylating agent which binds to a minor groove in DNA and alkylates adenine bases.

what are oestrogen antagonists?

name an oestrogen antagonist agent

What is tamoxifen

what is 17B-estradiol

what is the action of tamoxifen?§

What are antimetabolites?

name an antimetabolite

how are cancer cell plasma membranes altered?

what is the significance of the presence of antigens on the plasma membranes of cancer cells?

How do monoclonal antibodies work in the treatment of cancer?

monoclonal antibodies are useful in the treatment of what cancers?

disadvantage of using monoclonal antibodies?

what is herceptin?

what drug was approved in 1997 for the treatment of non-Hodgkin's lymphoma?

What is Rituximab?

what are chimeric antibodies?

Combination therapies are called _________.

in 2006 FDA approved R-CHOP as a first line treatment for?

R-CHOP is used for the treatment of a wide range of B-cell NHL subtypes including _______

outline R-CHOP treatment for beating cancer