Which one of the following local anesthetic agents is NOT an amide?
lidocaine
prilocaine
mepivicane
bupivicane
procaine
Which of the following are properly matched?
lidocaine: fast onset, moderate duration (1-2hrs)
lidocaine-less tissue rxn
mepivicaine fast onset, moderate duration (1-2hrs)
mepivicaine-often used in equine lameness
bupivicaine- slow onset, longer duration (3-4 hrs)
mepivicaine-our #1 local anesthetic
Local anesthetics block sodium channels in the following conformation(s):
activated-open
inactivated-closed
resting-closed
all of the above
Local anesthetics block nerve types in the following order: autonomic--> muscle tone--> pain--> touch, pressure--> proprioception/motor.
With regards to pharmacokinetics of local anesthetics and drug-tissue interaction: more potent, more lipid soluble, lower blood concentration.
Which are true regarding ester locals?
rapidly metabolized by liver cytochrome P450
cause allergic rxn because of formation of PABA intermediate
1st pass pulmonary uptake
What local anesthetic agent can cause methemoglobinemia in cats?
bupivicaine
What local anesthetic drug can cause neurotoxicity?
mepivicaine
cocaine
Bupivicaine can cause malignant arrhythmias.
Cetocaine spray is not recommended in cats bc it can cause the following problem:
seizures
cardiotoxicity
neurotoxicity
methemoglobinemia
