Haematology: Leukocytes

Two lineages from pluripotent stem cells:

Assessment of blood:
Quantitative assessment:
Qualitative assessment:

Pancytopenia:

Causes:

Leukoerythroblastic blood film:

Neutrophils:
Maturation sequence:
Immature neutrophil count:
Mature neutrophil count:
Function:
Neutrophil adhesion, migration and invagination:

Neutrophils can die via two ways:
NETosis (Neutrophil extracellular traps):
Roles for NETosis in disease:

Isolated neutropenia causes:

Neutropenia:
Critical cutoff:
If febrile:
If afebrile:

Neutrophilia:
Elevated neutrophils:
Causes:

Reactive neutrophil changes in severe inflammation:

Monocytes:
Function:
Mature from ________in the bone marrow.
They become ______ in tissues.
They constitute ____ of all cells in every organ

Monocytosis:
Causes:

To distinguish between the two:

Eosinophilia:
Causes:

Basophils:
Function:
Clinical utility:

Leukocytes:
3 main cell types in blood:

Lymphocytosis:
Causes in children:

Causes in adults:

Counting and identifying lymphocytes:
Techniques:
CD19 is expressed 0n__, CD3 on ___ and CD16/CD56 expressed on____.

Lymphopenia:
Not very useful clinically since we usually know the cause:

Natural killer cells/large granular lymphocytes:
Function:

Glandular fever-acute EBV infection:
Epstein Barr virus infects:
The large atypical lymphocytes in blood:
Infectious mononucleosis is a crazy name since:
Any age can be affected:
Symptoms:

Acute CMV:
Symptoms:
Seroprevalence and clinical concern: