three generation pedigree
Proband's health history - age, previous cancers, (for B/O age at menarche, age at first pregnancy, number of children, OCP use, age at menopause, use of HRT), history of risk reducing surgery
If affected - age at diagnosis, year of diagnosis, details of hospital treated at, tumour pathology, cancer treatment (e.g. chemotherapy), any hormonal treatment (e.g. tamoxifen)
Access histology reports, cancer registry, death certificates (requested by proband/relative), clinical notes to confirm diagnoses - consent needed from living indvs or if dead, living relative

**Factors that make a pedigree hard to interpret: small family size, non-paternity, fertility treatment, adoption, removal of at-risk organs, estrangement, late or variable onset, non-penetrance, variable expression, de novo mutations, mosaicism, consanguinity,

	Erstellt von Ellie Quinn vor mehr als 10 Jahre

Notiz am Risk Assessment, erstellt von Ellie Quinn am 28/05/2014.

Risk Assessment