Previous year Quizz 5

The NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies

The NOAEL is defined as the lowest dose at which at least one clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies

Attention deficits may be present

Motor dysfunction is an early warning sign.

Medical interventions prior to the first psychotic symptoms may be more effective

Brain structure that is clearly different from healthy individuals

Mild or moderate disturbance in language.

but it is not heritable

and its heritability is around 80%.

and environmental factors are not important.

and its heritability is around 10%.

but genetics factors are not associated with schizophrenia symptoms

selection bias (creating groups with different confounders; solved by randomization)

performance bias and detection bias (investigators respectively treating or assessing more positively those subjects on the treatment arm; controlled by blinding interventions and outcome assessments)

attrition bias (dropout of subjects with a negative outcome not included in the final result)

Hearing

Smelling

Language

Memory

Vision

Corpus striatum

Red nucleus

Subthalamic nucleus

Caudate nucleus

retrospectively combines all trials performed by one group

eliminates the bias introduced by studies of low quality

can only be performed when more than 10 trials have been performed

is a prospective trial of study quality

none of the above

Bioequivalence

First in Human

Pharmacokinetics in renal impairment

Proof of concept

Pharmacokinetic drug interaction

stop signals

reward signals

fear signals

motor signals

Weight gain

Influenza infection during pregnancy

Toxoplasmosis gondii

Age of father at conception

High expressed emotions families

better spectral resolution

better time resolution

better spatial resolution

higher amplification

A SUE is always related to the administration of the test substance

A SUSAR can be a serious or a non-serious adverse reaction

A SUSAR should be reported to Ethic Committee and Health Authorities

50%

90%

20 %

30%

E. 99%

IRB approval

Insurance Certificate

Data protection approval

Youth welfare office approval

Study bank account

The first dose in humans is equivalent to NOAEL

The first dose in humans is a fraction of NOAEL

The first dose in humans is higher than NOAEL

the inventor(s)

the funding agency

the University

Researcher(s) who are not employed by the University but inventor(s)

the University Researcher(s) who are not employed by the University but inventor(s)

receives inhibitory input from the cortex

consists of the lenticular nucleus and the putamen

receives dopaminergic input from the substantia nigra pars compacta

contains cells that use acetylcholine as their transmitter

all of the above statements are true

Babinski sign

akinesia

rigidity

uncontrollable involuntary movement

spasticity

Safety and tolerability

Feasibility

Pharmacodynamics

Therapeutic effect