1308146
Beschreibung
Quiz von Peter Seymour, aktualisiert more than 1 year ago
|
Erstellt von Peter Seymour
vor etwa 10 Jahre
|
|
Frage 1
Frage
A rapidly dividing cell will have a greater abundance of which nucleotide?
Antworten
-
Guanine and Adenine because purine synthesis is more important for a developing cell
-
Cytosine and Thiamine because pyrimidine synthesis is less taxing and therefore proceed more quickly
-
The concentration of pyrimidines and purines will be equal regardless of the conditions
-
Purines are critical for DNA replication, so purine concentration will be higher
Frage 2
Frage
Which of the following is a nucleotide?
Antworten
-
Image:138px-Adenin.svg (image/png)
Frage 3
Frage
For the previous question why was the correct answer the only nucleotide?
Antworten
-
It was the only answer that consisted of a nucleoside bound to a phosphate group
-
All of the other answers were sugars
-
All of the other answers were bases
-
None of the other answers were biologically important molecules
Frage 4
Frage
Which of the following is not a biological function of Nucleotides?
Antworten
-
They are precursors to glycogen and other phosphoglycerides
-
Nucleotides exclusively compromise the universal energy currency
-
They serve as metabolic regulators and mediate the action of many hormones
-
Nucleotides entirely make up three major co-enzymes: NADH, FAD, and CoA
Frage 5
Frage
cAMP is a nucleotide that mediates hormones
Antworten
- True
- False
Frage 6
Frage
Purine biosynthesis involves which of the following precursors?
Antworten
-
Glycine
-
Glutamine
-
Aspartate
-
carbon dioxide
-
Formyltetrahydrofolate
-
All of the above are required atom contributors
Frage 7
Frage
PRPP (Phosphoribosylpyrophosphate) is the source of the ribose sugar in...
Antworten
-
purine de novo synthesis and purine salvage pathways
-
purine de novo synthesis
-
purine salvage
-
purine and pyrimidine de novo synthesis
Frage 8
Frage
Which describes the committed step for purine de novo synthesis?
Antworten
-
Glutamine-PRPP amido-transferase is the active enzyme
-
PRPP feeds into the committed step
-
Glutamine feeds into the step and becomes glutamate
-
All of the above
Frage 9
Frage
THF is an enzyme that performs which of the following actions?
Antworten
-
Eliminates an amide group
-
Transfers one carbon from N10-Formyl THF to the growing purine precursor
-
Allosterically activates HGRPT
-
Facilitates a Glutamine dependent nitrogen tranfer
-
Facilitates ring closure of the growing purine
Frage 10
Frage
The base hypoxanthine is described by which of the following statements?
Antworten
-
Inosinic Acid (IMP) is the nucleoside form of hypoxanthine
-
Hypoxanthine is critical only to the conversion of IMP to GMP not IMP to AMP
-
Hypoxanthine is reduced to xanthine during the purine synthesis pathway
-
The oxidation of hypoxanthine to xanthine is blocked by allpurinol
Frage 11
Frage
PRPP impacts which of the following?
Antworten
-
De novo synthesis of purines
-
Direct production of IMP through PRPP's reaction with Hypoxanthine
-
Direct production of GMP through PRPP's reaction with Guanine
-
All of the above are catalyzed by HGPRT and all are true in healthy cells
Frage 12
Frage
Which of the following is deficient in Gout?
Antworten
-
HGPRT
-
ADA (adenosine deaminase)
-
PNP (purine nucleoside phosphorylase)
-
You have to be more specific, gout could be the result of numerous enzyme deficiencies
-
XO (xanthine oxidase)
Frage 13
Frage
Lesch Nyhan Syndrome is caused by a deficiency in which of the following?
Antworten
-
PRPP
-
XO (xanthine oxidase)
-
ADA (adenosine deaminase)
-
HGPRT
-
You have to provide more information, Lesch Nyhan Syndrome could be caused by the deficiency of a number of different enzymes
Frage 14
Frage
Which is the committed step of Pyrimidine synthesis?
Antworten
-
Aspartate Transcarbamoylase ATCase
-
Dihydroorotase
-
OPRT
-
CTP synthetase
Frage 15
Frage
Familial Orotic Aciduria can be treated using which of the following methods?
Antworten
-
There is no curative treatment, simply a management of symptoms
-
Delivery of large doses of orally administered uridine to simply bypass the early steps of pyrimidine synthesis
-
Delivery of large doses of the missing/deficient orotate phosphoribosyltransferase (OPRT)
-
Delivery of fully synthesized pyrimidines for uptake into the cell
Frage 16
Frage
Which of the following are made by a two enzyme complex (Thymidylate Synthetase and Dihydrofolate reductase) after ribonucleotide reductase acts on freshly minted purines and pyrimidines?
Antworten
-
dADP
-
dGDP
-
dCDP
-
dUDP
-
dTTP
Frage 17
Frage
dATP is the master negative regulator of Ribonucleotide Reductase.
Antworten
- True
- False
Frage 18
Frage
Which of the following enzymes should I know really well?
Antworten
-
Ribosomyl Reductase
-
PRPP Synthetase
-
Xanthine Oxidase
-
Dihydrofolate Reductase
-
HGPRT
-
Amidophosphoryl Transferase ATase = glutamine PRPP amidotransferase
-
I should probably know all of these
Frage 19
Frage
Why do we use "De Novo" instead of saying from scratch?
Antworten
-
Because Carl Sagan's famous Apple Pie from scratch comment makes it too awesome to use in any setting other than musing about the universe
-
Because De Novo is more descriptive
-
To confuse those who are sadly lacking in medical jargon
-
Because fancy language is awesome
Möchten Sie mit GoConqr kostenlos Ihre eigenen Quiz erstellen? eigenen Mehr erfahren.