Zusammenfassung der Ressource
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Fluoroquinoiones are:
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Gentamycin
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Moxifloxacin
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Ciprofloxacin
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Levofloxacin
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Mechanism of action of quinolones is:
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inhibition of protein synthesis
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inhibition of cell wall synthesis
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inhibition of topoisomerase II and IV
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inhibition of DNA transcription and replication
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Fluoroquinolones have:
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Point out the correct statements for pharmacokinetics of fluoroquinolones:
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bad oral absorption and are administered always parenterally
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distribute well into all tissues and body fluids
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inhibit some liver cytochromes
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most of them are excreted renally
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Fluoroquinolones are used for treatment of:
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Urinary tract infections
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Respiratory infections
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Skin infections
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Gl infections
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Adverse drug reactions of fluoroquinolones are:
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articular cartilage erosion (arthropathy)
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hypertension
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seizures in patients with epilepsy
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prolongation of QT interval
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Quinolones are contraindicated in
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pregnancy and breast-feeding
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children under 18 years of age
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patients with epilepsy
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patients with renal failure
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Drug interactions of fluoroquinolones are:
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increase serum levels of theophyiline by inhibiting its metabolism
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decrease serum levels of theophyiline by inducing its metabolism
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synergism with beta-lactams
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calcium and other divalent cations decrease their absorption