Frage 1
Frage
Functional antagonists of histamine are
Antworten
-
corticosteroids
-
opoid analgesics
-
adrenalin
-
neuroepileptics
Frage 2
Frage
2nd generation H1-blockers are
Antworten
-
Loratidine (Claritin)
-
Fexofenadine (Telfast)
-
Cetirizine (Zodac)
-
Dimenhydrinate (Vomacur)
Frage 3
Frage 4
Frage
5-HT 1D agonists are
Antworten
-
Sumatripan (Imigran)
-
Ranitidine (Zantac)
-
Loratidine (Claritin)
-
Naratripan (Naramig)
Frage 5
Frage
5-HT3 antagonists is
Antworten
-
Naratripan (Naramig)
-
Ondansetron (Zofran)
-
Clozapine (Leponex)
-
Desloratidine (Aerius)
Frage 6
Frage
What is the mechanism of action of local anesthetics?
Antworten
-
they reversibly block activated sodium channels
-
they block the potassium channels
-
they block the conduction of action potentials along axons
-
they block the β-receptors in the cell membrane
Frage 7
Frage
Which one of the following local anesthetics causes vasoconstriction?
Antworten
-
Lidocaine
-
Procaine
-
Cocaine
-
Mepivacaine
Frage 8
Frage
Cardiac glycosides are
Frage 9
Frage
Pharmacologic effects of cardiac glycosides are
Antworten
-
positive inotropic
-
negative chronotropic
-
negative dromotropic
-
positive batmotropic
Frage 10
Frage
What is the mechanism of action of cardiac glycosides?
Antworten
-
stimulation of M-cholinoreceptors
-
inhibition of Na+/K+-ATPase
-
inhibition of enzyme phosphodiesterase
-
an increase in the cyclic adenosine monophosphate
Frage 11
Frage
In the liver predominantly is mentioned
Frage 12
Frage
Symptoms of cardiac glycosides intoxication
Antworten
-
loss of appetite, vomiting
-
muscle weakness, tremors
-
hallucinations, yellowish vision (xanthopsia)
-
ventricular extrasystoles, atrioventricular block
Frage 13
Frage
Antiarrhythmics of class III are
Antworten
-
Propranolol
-
Amiodarone
-
Sotalol
-
Quinidine sulfate
Frage 14
Frage
Class IVA antiarrhytmics (calcium channel blockers) are
Antworten
-
Diltiazem
-
Lidocain
-
Sotalol
-
Verapamil
Frage 15
Frage
The mechanism of action of antiarhytmics includes
Antworten
-
affect the generation and induction/conduction of action potential in the heart
-
slow conduction of action potential
-
blocking of cholinesterase
-
changes in trsport of K+, Na+, or Ca++ ions
Frage 16
Frage
Contraindications for clinical use Amiodarone are
Frage 17
Frage
Organic nitrates with rapid onset and short duration of action are:
Antworten
-
Glyceryl trinitrate (Nitroglycerin)
-
Subiingual spray containing lsosorbide-dinitrat (lsoket spray)
-
Tablets containing Isosorbide-dinitrat (lsodinit)
-
Tablets containing Isosorbide-5-mononitrat (Monisid)
Frage 18
Frage
The mechanism of action of organic nitrates is related to:
Frage 19
Frage
Adverse drug reactions of organic nitrates are:
Antworten
-
tachycardia
-
tolerance
-
headache and flushing
-
hypertension
Frage 20
Frage
Dihydropyridine calcium-channel blockers are:
Antworten
-
Verapamil
-
Nifedipine
-
Felodipine
-
Diltiazem
Frage 21
Frage
Adverse drug reactions of dihydropyridine calcium-channel blockers are:
Antworten
-
tachycardia
-
bradycardia
-
headache
-
swelling of the ankles
Frage 22
Frage
Adverse drug reactions of non-dihydropyridine calcium-channel blockers are:
Antworten
-
Bradycardia
-
Tachycardia
-
Constipation
-
Heart failure
Frage 23
Frage
Peripheral vasodilators phosphodiesterase inhibitors are:
Frage 24
Frage
Pharmacological effects of Papaverin and Drotaverin are
Frage 25
Frage
Inhibitors of hydroxy-methylgIutaryl-CoA-reductase (HMG-CoA reductase) are:
Frage 26
Frage
Mechanisms of action of statins are:
Antworten
-
inhibit HMG-CoA-reductase
-
inhibits the deposition of cholesterol in the blood vessel wall
-
accelerate the elimination of cholesterol
-
inhibit the synthesis of Cholesterol and LDL
Frage 27
Frage
Adverse drug reactions of statins are:
Frage 28
Frage
What is the mechanism at action of Ezetimibe?
Antworten
-
inhibits the synthesis of Cholesterol
-
inhibits the intestinal absorption of Cholesterol
-
enhances the elimination of Cholesterol
-
blocks the LDL receptors
Frage 29
Frage
Pharmacological effects of ACE inhibitors are:
Frage 30
Frage
Adverse drug reactions of ACE inhibitors are:
Antworten
-
dry cough
-
hyperglycaemia
-
hyperkalemia
-
hypotension
Frage 31
Frage
Indications for clinical use of ACE inhibitors are:
Frage 32
Frage
Angiotensin II receptor antagonists are:
Antworten
-
Losartan
-
Enalapril
-
Valsartan
-
Telmisartan
Frage 33
Frage
Adverse drug reactions of β blockers are:
Frage 34
Frage
Adverse drug reactions of thiazide diuretics are:
Antworten
-
hyperkalemia
-
hypokalemia
-
hyperglycaemia
-
hyperuricemia
Frage 35
Antworten
-
Prazosin (Minipress)
-
Enalapril (Renitec)
-
Doxazosin.(Cardura)
-
Diltiazem (Aldizem)
Frage 36
Frage
Adverse drug reactions of α1-blockers are:
Frage 37
Frage
Indications for clinical use of α1-blockers are:
Antworten
-
prostatic hypertrophy
-
tachycardia
-
hypertension
-
angina pectoris
Frage 38
Frage
The site of action of loop diuretics is:
Frage 39
Frage
Which of the following diuretics are thiazides?
Antworten
-
Hydrochlorthiazide
-
lndapamide
-
Spironolactonum
-
Mannitol
Frage 40
Frage
Which of the following diuretics is an aldosterone receptor antagonist?
Antworten
-
Triamteren
-
Furosemide
-
Spironolactone
-
Mannitol
Frage 41
Frage
Clinical indications for prescribing diuretics are
Antworten
-
brain edema
-
diabetes mellitus
-
hypertension
-
chronic heart failure
Frage 42
Frage
Adverse drug reactions of potassium - sparing diuretics are:
Antworten
-
gynecomastia
-
hyperkalemia
-
hepatotoxicity
-
ototoxicity
Frage 43
Frage
For Vitamin K is true:
Antworten
-
participate as a cofactor in the biosynthesis of clotting factors II, VII, IX, X
-
exists in two natural forms - Vitamin K1 and K2
-
it is an antidote of heparin
-
it is used for prevention and treatment of bleeding associated with overdose of indirect anticoagulants
Frage 44
Frage
Indications for clinical use of fibrlnolytlcs are:
Frage 45
Frage
Adverse drug reactions of heparin are:
Frage 46
Frage
Antidote for heparin is:
Frage 47
Frage
What is the mechanism of action of Dabigatran?
Antworten
-
inhibits factor Xa of coagulation
-
inhibits factor ll of coagulation
-
binds to anti-thrombin lll
-
oppose the action of Vitamin K
Frage 48
Frage
For indirect oral anticoagulants is true:
Frage 49
Frage
Antiplatelet agents are:
Antworten
-
Acidum p-aminomethylbenzoicum (PAMBA)
-
Clopidogrel (PIavix)
-
Dipyridamole (Antistenocardin)
-
Acidum acetylsalicylicum (Acetysal)
Frage 50
Frage
Adverse drug reactions of iron preparations for oral use are:
Antworten
-
constipation
-
epigastric pain, nausea, vomiting
-
thrombosis
-
dark-colored gums and teeth
Frage 51
Frage
Which of the following groups are used to treat asthma?
Frage 52
Frage
Which of the following drugs are phosphodiesterase inhibitors
Antworten
-
Salbutamol
-
Theophylline
-
Aminophylline
-
Ketotifen
Frage 53
Frage
What is the mechanism of action at methylxantines?
Antworten
-
they inhibit MAO
-
they inhibit acetylcholinesterase
-
they inhibit phosphodiesterase and increase the cAMP
-
they inhibit angiotensin converting enzyme
Frage 54
Frage
What are the adverse drug reactions of the inhaled corticosteroids:
Antworten
-
bronchoconstriction
-
dysphonia (hoarse voice)
-
oral candidiasis
-
hypertensive crisis
Frage 55
Frage
What are the potential adverse drug reactions of the systemic corticosteroids?
Antworten
-
diabetes
-
obesity
-
osteoporosis
-
insomnia
Frage 56
Frage
Ipratropii bromidum (Atrovent) is:
Antworten
-
leukotriene inhibitor
-
corticosteroid
-
cholinergic antagonist
-
cholinergic agonist
Frage 57
Frage
What are the possible adverse drug reactions of Ipratropii bromidum (Atrovent)?
Antworten
-
dry mouth
-
incontinention of urine
-
tachycardia
-
hypoglycaemia
Frage 58
Frage
What are the mechanisms of action of the leukotriene modifiers?
Antworten
-
they block the M-Choiinoceptors
-
they are selective, reversible antagonists of the Ieukotriene-1 receptor
-
they inhibit the enzyme 5-lypoexigenase
-
they inhibit the angiotensin converting enzyme
Frage 59
Frage
Which of the following drugs are mucolytics?
Antworten
-
Amroxol (Mucosoivan)
-
Bromhexine
-
Salbutamol
-
Ketotifen
Frage 60
Frage
Which are the drugs used for treatment of peptic ulcer disease
Antworten
-
mucosal protective agents
-
H1-histamine receptor blockers
-
H2-histamine receptor blockers
-
proton pump inhibitors
Frage 61
Frage
H2-histamine receptor blockers are:
Antworten
-
Roxatidine
-
Ranitidine
-
Sucralfate
-
Omeprazole
Frage 62
Frage 63
Frage
Drugs interactions of Omeprazol are due to:
Frage 64
Frage
Hepatoprotective agents with regenerative action are:
Antworten
-
Essentiale
-
Silymarin
-
Ademetionine
-
Oleum Ricini
Frage 65
Frage
Glucocorticoid preparations are:
Antworten
-
Hydrocortisone
-
Methylprednisolone
-
Fludroconisone
-
Prednisolon
Frage 66
Frage
Metabolic effect of glucocorticoids are:
Frage 67
Frage
Pharmacological effects of glucocorticoids are
Antworten
-
hypotension
-
anti-inflammatory action
-
immunosuppressive action
-
antiallergic action
Frage 68
Frage
Side effects of glucocorticoids are:
Antworten
-
osteoporosis
-
diabetes mellitus
-
cough
-
hypertension
Frage 69
Frage
Short-acting insulin preparations are:
Antworten
-
Actrapid
-
Humulin N
-
lnsuman Rapid
-
Humulin R
Frage 70
Frage
Effects of insulin-on carbohydrate metabolism are.
Frage 71
Frage
ADRs of insulin are:
Antworten
-
hypoglycaemia
-
hypotension
-
insulin resistance
-
allergy
Frage 72
Frage
Mechanisms of action of sulphonyureas are:
Antworten
-
block ATP-sensitive K+ channels
-
stimulate release of endogenous insulin from the pancreas
-
inhibit gluconeogenesis
-
lower levels of plasma glucagon
Frage 73
Frage
ADRs of sulphonylureas are:
Antworten
-
hypotension
-
weight gain
-
gastrointestinal
-
hypoglycaemia
Frage 74
Frage
Biguanide antidiabetic agent is:
Antworten
-
Pioglitazone
-
Metformin
-
Glibenclamide
-
Acarbose
Frage 75
Frage
Mechanisms of action of biguanides are:
Antworten
-
inhibition of gluconeogenesis
-
release of insulin from β cells of the pancreas
-
increased peripheral utilization of glucose
-
inhibition of glucose absorption from the gastrointestinal tract
Frage 76
Frage
ADRs of biguanides are:
Antworten
-
gastrointestinal disorders (anorexia, nausea, diarrhoea, metallic, taste)
-
hypoglycaemia
-
megaloblastic anemia
-
lactic acidosis
Frage 77
Frage
Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors):
Antworten
-
prolong activity of incretin hormones
-
release insulin from β cells of the pancreas
-
do not cause hypoglycaemia
-
cause weight gain and increased appetite
Frage 78
Frage
Reproductive effects of estrogens are:
Antworten
-
development of sexual organs
-
development of the follicular phase of menstrual cycle
-
development of the luteal phase of menstrual cycle
-
stimulate uterine contractions
Frage 79
Frage
ADRs of estrogens are:
Antworten
-
hypertension
-
thrombosis
-
carcinogenic effects
-
nephrotoxicity
Frage 80
Frage
Contraindications for use of estrogens are
Frage 81
Frage
Mechanisms of action of oral hormonal contraceptives are:
Antworten
-
Suppression of ovulation
-
Suppression of lutein hormone secretion
-
Condensation of cervical mucus
-
Increased secretion of follicle stimulating hormone
Frage 82
Frage
Contraindications of oral contraceptives are:
Frage 83
Frage
Symptoms of vitamin B3 deficiency (pellagra) are
Antworten
-
dermatitis
-
anemia
-
diarrhea
-
dementia
Frage 84
Frage
Vitamin B12 deficiency leads to:
Frage 85
Frage
Vitamin A deficiency leads to:
Frage 86
Frage
Effects of vitamin D on calcium and phosphate homeostasis are:
Antworten
-
increased intestinal calcium and phosphate absorption
-
decreased intestinal calcium and phosphate
-
stimulation of calcium reabsorption in the kidney
-
deposition of calcium in bones and teeth (at low dose)
Frage 87
Frage
Vitamin D deficiency leads to:
Antworten
-
rickets in children
-
osteomalacia in adults
-
delayed dentation
-
hyperglycemia
Frage 88
Frage
Vitamin K is required for:
Antworten
-
synthesis of hemoglobin
-
synthesis of clotting factors II, VII, IX and X
-
regulation of cholesterol levels
-
carbohydrate metabolism
Frage 89
Frage
Drugs for treatment of Parkinson's disease are
Antworten
-
neuroepileptics
-
dopaminergic drugs
-
antimuscarinic drugs
-
anxiolytics
Frage 90
Frage
Mode of action of Selegiline is
Frage 91
Frage
Therapeutic uses of Bromocriptine are
Frage 92
Frage
Antiparkinsonian drug with antiviral activity is
Antworten
-
Amantadine
-
Bromocriptine
-
Selegiline
-
Madopar
Frage 93
Frage
Mode of action of typical antipsychotics involves:
Antworten
-
block of postsynaptic dopamine receptors
-
activation of dopamine receptors
-
block of serotonin receptors
-
block of muscarinic, histamine and adrenergic receptors
Frage 94
Frage
Mode of action of atypical antipsychotic Olanzapine involves:
Antworten
-
block of postsynaptic D4 receptors stronger than D2 receptors
-
block of 5-HT2 receptors
-
activation of 5-HT2 receptors
-
stimulation of muscarinic receptors
Frage 95
Frage
The main effects of antipsychotics are:
Antworten
-
antipsychotic effect
-
antiemetic effect
-
hypotensive effect
-
anticonvulsant effect
Frage 96
Frage
Adverse drug reactions of antipsychotics are:
Antworten
-
extrapyramidal syndrome
-
hyperprolactinemia
-
drug dependence
-
postural hypotension
Frage 97
Frage
Antipsychotic with strong antipsychotic effect is:
Antworten
-
Chlorprothixene
-
Thioridazine
-
Haloperidol
-
Clozapine
Frage 98
Frage
Mode of action of benzodiazepines is:
Frage 99
Frage
Adverse drug reactions of benzodiazepines are:
Frage 100
Frage
Antagonist of benzodiazepines is:
Antworten
-
Naloxone
-
Flumazenil
-
Chlorpromazine
-
Clozapine
Frage 101
Frage
Opioids are suitable for treatment of
Frage 102
Frage
Contraindications for the use of opioid analgesics:
Frage 103
Frage
Specific morphine antagonist is:
Antworten
-
Flumazenil
-
Naloxone
-
Bemegrid
-
Protamin sulfas
Frage 104
Frage
Point out the correct statements for Pethidine (Lydol):
Antworten
-
has a spasmolytic effect on the smooth muscles
-
it is a stronger analgesic than morphine
-
has a shorter duration of action than morphine
-
can be used for neuroleptanaigesia
Frage 105
Frage
Opioid drug with a strong anti-tussive effect is:
Antworten
-
Tramadol
-
Pethidin
-
Morphine
-
Codeine
Frage 106
Frage
For analgesics-antipyretics is true:
Antworten
-
they affect normal body temperature
-
the antipyretic effect is clue to suppression of PgE synthesis in the hypothalamus
-
they lower only elevated body temperature (i.e. fever)
-
intensify heat diffusion
Frage 107
Frage
Adverse drug reactions of Metamizol (Analgin) are:
Antworten
-
allergic reactions
-
hyperthermla
-
agranulocytosis
-
red coloured urine
Frage 108
Frage
Pharmacological effects of Paracetamol are:
Antworten
-
antipyretic
-
anti-inflammatory
-
analgesic
-
antiplatelet
Frage 109
Frage
What are the therapeutic effects of NSAIDs:
Antworten
-
analgesic
-
anti-inflammatory
-
hypnotic
-
antipyretic
Frage 110
Frage
What is the mechanism of action of NSAiDs:
Antworten
-
inhibition of phosphodiesterases
-
blockade of dopamine receptors
-
inhibition of cyclooxygenase
-
inhibition of MAO
Frage 111
Frage
Pharmacological effects of salicylates are:
Antworten
-
anti-inflammatory
-
sedative
-
analgesic
-
antiplatelet
Frage 112
Frage
Which of the following drugs are selective COX-2 inhibitors:
Antworten
-
Aspirin
-
Celecoxib
-
Indomethacin
-
Meloxicam