Pharmacology MCQs 2- 4th Year- PMU

Beschreibung

Pharmacology MCQs- 4th Year- PMU
Med Student
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Zusammenfassung der Ressource

Frage 1

Frage
Functional antagonists of histamine are
Antworten
  • corticosteroids
  • opoid analgesics
  • adrenalin
  • neuroepileptics

Frage 2

Frage
2nd generation H1-blockers are
Antworten
  • Loratidine (Claritin)
  • Fexofenadine (Telfast)
  • Cetirizine (Zodac)
  • Dimenhydrinate (Vomacur)

Frage 3

Frage
H2-blockers are
Antworten
  • Omeprazole (Sopral)
  • Ranitidine (Zantac)
  • Bismuth collodial (De-nol)
  • Famotidine (Famultran)

Frage 4

Frage
5-HT 1D agonists are
Antworten
  • Sumatripan (Imigran)
  • Ranitidine (Zantac)
  • Loratidine (Claritin)
  • Naratripan (Naramig)

Frage 5

Frage
5-HT3 antagonists is
Antworten
  • Naratripan (Naramig)
  • Ondansetron (Zofran)
  • Clozapine (Leponex)
  • Desloratidine (Aerius)

Frage 6

Frage
What is the mechanism of action of local anesthetics?
Antworten
  • they reversibly block activated sodium channels
  • they block the potassium channels
  • they block the conduction of action potentials along axons
  • they block the β-receptors in the cell membrane

Frage 7

Frage
Which one of the following local anesthetics causes vasoconstriction?
Antworten
  • Lidocaine
  • Procaine
  • Cocaine
  • Mepivacaine

Frage 8

Frage
Cardiac glycosides are
Antworten
  • Digoxin
  • Beta-methyldigoxin (Lanitop)
  • Digitoxin
  • Theophyllin

Frage 9

Frage
Pharmacologic effects of cardiac glycosides are
Antworten
  • positive inotropic
  • negative chronotropic
  • negative dromotropic
  • positive batmotropic

Frage 10

Frage
What is the mechanism of action of cardiac glycosides?
Antworten
  • stimulation of M-cholinoreceptors
  • inhibition of Na+/K+-ATPase
  • inhibition of enzyme phosphodiesterase
  • an increase in the cyclic adenosine monophosphate

Frage 11

Frage
In the liver predominantly is mentioned
Antworten
  • Digoxin
  • Acetyldigoxin
  • Beta-methyldigoxin (Lanitop)
  • Digitalin (Digitoxin)

Frage 12

Frage
Symptoms of cardiac glycosides intoxication
Antworten
  • loss of appetite, vomiting
  • muscle weakness, tremors
  • hallucinations, yellowish vision (xanthopsia)
  • ventricular extrasystoles, atrioventricular block

Frage 13

Frage
Antiarrhythmics of class III are
Antworten
  • Propranolol
  • Amiodarone
  • Sotalol
  • Quinidine sulfate

Frage 14

Frage
Class IVA antiarrhytmics (calcium channel blockers) are
Antworten
  • Diltiazem
  • Lidocain
  • Sotalol
  • Verapamil

Frage 15

Frage
The mechanism of action of antiarhytmics includes
Antworten
  • affect the generation and induction/conduction of action potential in the heart
  • slow conduction of action potential
  • blocking of cholinesterase
  • changes in trsport of K+, Na+, or Ca++ ions

Frage 16

Frage
Contraindications for clinical use Amiodarone are
Antworten
  • sinus bradycardia
  • sinus tachycardia
  • opthalmological diseases
  • thyroid gland dysfunction

Frage 17

Frage
Organic nitrates with rapid onset and short duration of action are:
Antworten
  • Glyceryl trinitrate (Nitroglycerin)
  • Subiingual spray containing lsosorbide-dinitrat (lsoket spray)
  • Tablets containing Isosorbide-dinitrat (lsodinit)
  • Tablets containing Isosorbide-5-mononitrat (Monisid)

Frage 18

Frage
The mechanism of action of organic nitrates is related to:
Antworten
  • release of nitric oxide
  • direct vasodilation
  • blocking the enzyme phosphodiesterase
  • activation of the enzyme adenilatcyclase

Frage 19

Frage
Adverse drug reactions of organic nitrates are:
Antworten
  • tachycardia
  • tolerance
  • headache and flushing
  • hypertension

Frage 20

Frage
Dihydropyridine calcium-channel blockers are:
Antworten
  • Verapamil
  • Nifedipine
  • Felodipine
  • Diltiazem

Frage 21

Frage
Adverse drug reactions of dihydropyridine calcium-channel blockers are:
Antworten
  • tachycardia
  • bradycardia
  • headache
  • swelling of the ankles

Frage 22

Frage
Adverse drug reactions of non-dihydropyridine calcium-channel blockers are:
Antworten
  • Bradycardia
  • Tachycardia
  • Constipation
  • Heart failure

Frage 23

Frage
Peripheral vasodilators phosphodiesterase inhibitors are:
Antworten
  • Papaverini hydrochloridum
  • Pentoxifiyllin (Agapurin)
  • Cinnarizin (Stugeron)
  • Drotaverini (No-spa)

Frage 24

Frage
Pharmacological effects of Papaverin and Drotaverin are
Antworten
  • vasodilation
  • platelet aggregation inhibition
  • antispasmodic
  • antianginal

Frage 25

Frage
Inhibitors of hydroxy-methylgIutaryl-CoA-reductase (HMG-CoA reductase) are:
Antworten
  • Bezafibrate (Bezalip)
  • Atorvastatin (Sortis)
  • Simvastatin (Zooor)
  • Cholestyramine (Questran)

Frage 26

Frage
Mechanisms of action of statins are:
Antworten
  • inhibit HMG-CoA-reductase
  • inhibits the deposition of cholesterol in the blood vessel wall
  • accelerate the elimination of cholesterol
  • inhibit the synthesis of Cholesterol and LDL

Frage 27

Frage
Adverse drug reactions of statins are:
Antworten
  • gastrointestinal disorders
  • hypertension
  • hepatotoxicity
  • myositis

Frage 28

Frage
What is the mechanism at action of Ezetimibe?
Antworten
  • inhibits the synthesis of Cholesterol
  • inhibits the intestinal absorption of Cholesterol
  • enhances the elimination of Cholesterol
  • blocks the LDL receptors

Frage 29

Frage
Pharmacological effects of ACE inhibitors are:
Antworten
  • antihypertensive
  • antiarrhythmic
  • regression of left ventricular hypertrophy
  • nephroprotective

Frage 30

Frage
Adverse drug reactions of ACE inhibitors are:
Antworten
  • dry cough
  • hyperglycaemia
  • hyperkalemia
  • hypotension

Frage 31

Frage
Indications for clinical use of ACE inhibitors are:
Antworten
  • heart failure
  • ventricular extrasystoles
  • hypertension
  • acute angina attack

Frage 32

Frage
Angiotensin II receptor antagonists are:
Antworten
  • Losartan
  • Enalapril
  • Valsartan
  • Telmisartan

Frage 33

Frage
Adverse drug reactions of β blockers are:
Antworten
  • hypoglycaemia
  • bronchoconstriction
  • tachycardia
  • peripheral vascular spasms

Frage 34

Frage
Adverse drug reactions of thiazide diuretics are:
Antworten
  • hyperkalemia
  • hypokalemia
  • hyperglycaemia
  • hyperuricemia

Frage 35

Frage
α1-blockers are:
Antworten
  • Prazosin (Minipress)
  • Enalapril (Renitec)
  • Doxazosin.(Cardura)
  • Diltiazem (Aldizem)

Frage 36

Frage
Adverse drug reactions of α1-blockers are:
Antworten
  • orthostatic hypotension
  • bronchoconstriction
  • retention of sodium and water
  • bradycardia

Frage 37

Frage
Indications for clinical use of α1-blockers are:
Antworten
  • prostatic hypertrophy
  • tachycardia
  • hypertension
  • angina pectoris

Frage 38

Frage
The site of action of loop diuretics is:
Antworten
  • glomerulus
  • loop of Henle
  • proximal convoluted tubule
  • distal convoluted tubule

Frage 39

Frage
Which of the following diuretics are thiazides?
Antworten
  • Hydrochlorthiazide
  • lndapamide
  • Spironolactonum
  • Mannitol

Frage 40

Frage
Which of the following diuretics is an aldosterone receptor antagonist?
Antworten
  • Triamteren
  • Furosemide
  • Spironolactone
  • Mannitol

Frage 41

Frage
Clinical indications for prescribing diuretics are
Antworten
  • brain edema
  • diabetes mellitus
  • hypertension
  • chronic heart failure

Frage 42

Frage
Adverse drug reactions of potassium - sparing diuretics are:
Antworten
  • gynecomastia
  • hyperkalemia
  • hepatotoxicity
  • ototoxicity

Frage 43

Frage
For Vitamin K is true:
Antworten
  • participate as a cofactor in the biosynthesis of clotting factors II, VII, IX, X
  • exists in two natural forms - Vitamin K1 and K2
  • it is an antidote of heparin
  • it is used for prevention and treatment of bleeding associated with overdose of indirect anticoagulants

Frage 44

Frage
Indications for clinical use of fibrlnolytlcs are:
Antworten
  • bleeding stomach ulcer
  • acute myocardial infarction
  • pulmonary thromboembolism
  • hemophilia

Frage 45

Frage
Adverse drug reactions of heparin are:
Antworten
  • osteoporosis (by prolonged administration)
  • reversible alopecia
  • hemorrhage
  • allergic reactions

Frage 46

Frage
Antidote for heparin is:
Antworten
  • Streptase (Streptokinase)
  • Sodium chloride
  • Protamin sulfas
  • Phytomenadione (Vit. K1)

Frage 47

Frage
What is the mechanism of action of Dabigatran?
Antworten
  • inhibits factor Xa of coagulation
  • inhibits factor ll of coagulation
  • binds to anti-thrombin lll
  • oppose the action of Vitamin K

Frage 48

Frage
For indirect oral anticoagulants is true:
Antworten
  • good oral absorption
  • their anticoagulant effect occurs only in vivo
  • their effect is delayed
  • their anticoagulant effect occurs only in vitro

Frage 49

Frage
Antiplatelet agents are:
Antworten
  • Acidum p-aminomethylbenzoicum (PAMBA)
  • Clopidogrel (PIavix)
  • Dipyridamole (Antistenocardin)
  • Acidum acetylsalicylicum (Acetysal)

Frage 50

Frage
Adverse drug reactions of iron preparations for oral use are:
Antworten
  • constipation
  • epigastric pain, nausea, vomiting
  • thrombosis
  • dark-colored gums and teeth

Frage 51

Frage
Which of the following groups are used to treat asthma?
Antworten
  • B2-adrenergic agonists
  • Phosphodiesterase inhibitors
  • Butyrophenones
  • Leukotriene receptor antagonists

Frage 52

Frage
Which of the following drugs are phosphodiesterase inhibitors
Antworten
  • Salbutamol
  • Theophylline
  • Aminophylline
  • Ketotifen

Frage 53

Frage
What is the mechanism of action at methylxantines?
Antworten
  • they inhibit MAO
  • they inhibit acetylcholinesterase
  • they inhibit phosphodiesterase and increase the cAMP
  • they inhibit angiotensin converting enzyme

Frage 54

Frage
What are the adverse drug reactions of the inhaled corticosteroids:
Antworten
  • bronchoconstriction
  • dysphonia (hoarse voice)
  • oral candidiasis
  • hypertensive crisis

Frage 55

Frage
What are the potential adverse drug reactions of the systemic corticosteroids?
Antworten
  • diabetes
  • obesity
  • osteoporosis
  • insomnia

Frage 56

Frage
Ipratropii bromidum (Atrovent) is:
Antworten
  • leukotriene inhibitor
  • corticosteroid
  • cholinergic antagonist
  • cholinergic agonist

Frage 57

Frage
What are the possible adverse drug reactions of Ipratropii bromidum (Atrovent)?
Antworten
  • dry mouth
  • incontinention of urine
  • tachycardia
  • hypoglycaemia

Frage 58

Frage
What are the mechanisms of action of the leukotriene modifiers?
Antworten
  • they block the M-Choiinoceptors
  • they are selective, reversible antagonists of the Ieukotriene-1 receptor
  • they inhibit the enzyme 5-lypoexigenase
  • they inhibit the angiotensin converting enzyme

Frage 59

Frage
Which of the following drugs are mucolytics?
Antworten
  • Amroxol (Mucosoivan)
  • Bromhexine
  • Salbutamol
  • Ketotifen

Frage 60

Frage
Which are the drugs used for treatment of peptic ulcer disease
Antworten
  • mucosal protective agents
  • H1-histamine receptor blockers
  • H2-histamine receptor blockers
  • proton pump inhibitors

Frage 61

Frage
H2-histamine receptor blockers are:
Antworten
  • Roxatidine
  • Ranitidine
  • Sucralfate
  • Omeprazole

Frage 62

Frage
Omeprazole is:
Antworten
  • H2-histamine receptor blocker
  • H1-histamine receptor blocker
  • Proton pump inhibitor
  • Antimuscarinic drug

Frage 63

Frage
Drugs interactions of Omeprazol are due to:
Antworten
  • inhibition of CYP 450
  • induction of CYP 450
  • inhibition of phosphodiesterase
  • induction of phosphodiasterase

Frage 64

Frage
Hepatoprotective agents with regenerative action are:
Antworten
  • Essentiale
  • Silymarin
  • Ademetionine
  • Oleum Ricini

Frage 65

Frage
Glucocorticoid preparations are:
Antworten
  • Hydrocortisone
  • Methylprednisolone
  • Fludroconisone
  • Prednisolon

Frage 66

Frage
Metabolic effect of glucocorticoids are:
Antworten
  • hypoglycemia
  • hyperglycemia
  • reduced calcium absorption
  • increased protein catabolism

Frage 67

Frage
Pharmacological effects of glucocorticoids are
Antworten
  • hypotension
  • anti-inflammatory action
  • immunosuppressive action
  • antiallergic action

Frage 68

Frage
Side effects of glucocorticoids are:
Antworten
  • osteoporosis
  • diabetes mellitus
  • cough
  • hypertension

Frage 69

Frage
Short-acting insulin preparations are:
Antworten
  • Actrapid
  • Humulin N
  • lnsuman Rapid
  • Humulin R

Frage 70

Frage
Effects of insulin-on carbohydrate metabolism are.
Antworten
  • hyperglycaemia
  • hypoglycaemia
  • inhibition of gluconeogenesis
  • inhibition of glicogenolysis

Frage 71

Frage
ADRs of insulin are:
Antworten
  • hypoglycaemia
  • hypotension
  • insulin resistance
  • allergy

Frage 72

Frage
Mechanisms of action of sulphonyureas are:
Antworten
  • block ATP-sensitive K+ channels
  • stimulate release of endogenous insulin from the pancreas
  • inhibit gluconeogenesis
  • lower levels of plasma glucagon

Frage 73

Frage
ADRs of sulphonylureas are:
Antworten
  • hypotension
  • weight gain
  • gastrointestinal
  • hypoglycaemia

Frage 74

Frage
Biguanide antidiabetic agent is:
Antworten
  • Pioglitazone
  • Metformin
  • Glibenclamide
  • Acarbose

Frage 75

Frage
Mechanisms of action of biguanides are:
Antworten
  • inhibition of gluconeogenesis
  • release of insulin from β cells of the pancreas
  • increased peripheral utilization of glucose
  • inhibition of glucose absorption from the gastrointestinal tract

Frage 76

Frage
ADRs of biguanides are:
Antworten
  • gastrointestinal disorders (anorexia, nausea, diarrhoea, metallic, taste)
  • hypoglycaemia
  • megaloblastic anemia
  • lactic acidosis

Frage 77

Frage
Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors):
Antworten
  • prolong activity of incretin hormones
  • release insulin from β cells of the pancreas
  • do not cause hypoglycaemia
  • cause weight gain and increased appetite

Frage 78

Frage
Reproductive effects of estrogens are:
Antworten
  • development of sexual organs
  • development of the follicular phase of menstrual cycle
  • development of the luteal phase of menstrual cycle
  • stimulate uterine contractions

Frage 79

Frage
ADRs of estrogens are:
Antworten
  • hypertension
  • thrombosis
  • carcinogenic effects
  • nephrotoxicity

Frage 80

Frage
Contraindications for use of estrogens are
Antworten
  • thromboembolic disease
  • probable or certain pregnancy
  • proven or suspected breast cancer
  • migraine

Frage 81

Frage
Mechanisms of action of oral hormonal contraceptives are:
Antworten
  • Suppression of ovulation
  • Suppression of lutein hormone secretion
  • Condensation of cervical mucus
  • Increased secretion of follicle stimulating hormone

Frage 82

Frage
Contraindications of oral contraceptives are:
Antworten
  • Oestrogen dependant tumors
  • Hyper-coagulation
  • Migraine
  • Liver disease

Frage 83

Frage
Symptoms of vitamin B3 deficiency (pellagra) are
Antworten
  • dermatitis
  • anemia
  • diarrhea
  • dementia

Frage 84

Frage
Vitamin B12 deficiency leads to:
Antworten
  • megaloblastic anemia
  • spinal cord degeneration and neuropathies
  • atrophic glossitis
  • diarrhea

Frage 85

Frage
Vitamin A deficiency leads to:
Antworten
  • hemeralopia (night blindness)
  • acne
  • xerophthalmia (dry eyes)
  • bradycardia

Frage 86

Frage
Effects of vitamin D on calcium and phosphate homeostasis are:
Antworten
  • increased intestinal calcium and phosphate absorption
  • decreased intestinal calcium and phosphate
  • stimulation of calcium reabsorption in the kidney
  • deposition of calcium in bones and teeth (at low dose)

Frage 87

Frage
Vitamin D deficiency leads to:
Antworten
  • rickets in children
  • osteomalacia in adults
  • delayed dentation
  • hyperglycemia

Frage 88

Frage
Vitamin K is required for:
Antworten
  • synthesis of hemoglobin
  • synthesis of clotting factors II, VII, IX and X
  • regulation of cholesterol levels
  • carbohydrate metabolism

Frage 89

Frage
Drugs for treatment of Parkinson's disease are
Antworten
  • neuroepileptics
  • dopaminergic drugs
  • antimuscarinic drugs
  • anxiolytics

Frage 90

Frage
Mode of action of Selegiline is
Antworten
  • MAO A inhibition
  • Release of dopamine from the stores
  • MAO B inhibition
  • Activation of dopamine recepors

Frage 91

Frage
Therapeutic uses of Bromocriptine are
Antworten
  • Parkinson's disease
  • Acromegaly
  • Prolactin-secreting adenomas
  • Hyperglycemia

Frage 92

Frage
Antiparkinsonian drug with antiviral activity is
Antworten
  • Amantadine
  • Bromocriptine
  • Selegiline
  • Madopar

Frage 93

Frage
Mode of action of typical antipsychotics involves:
Antworten
  • block of postsynaptic dopamine receptors
  • activation of dopamine receptors
  • block of serotonin receptors
  • block of muscarinic, histamine and adrenergic receptors

Frage 94

Frage
Mode of action of atypical antipsychotic Olanzapine involves:
Antworten
  • block of postsynaptic D4 receptors stronger than D2 receptors
  • block of 5-HT2 receptors
  • activation of 5-HT2 receptors
  • stimulation of muscarinic receptors

Frage 95

Frage
The main effects of antipsychotics are:
Antworten
  • antipsychotic effect
  • antiemetic effect
  • hypotensive effect
  • anticonvulsant effect

Frage 96

Frage
Adverse drug reactions of antipsychotics are:
Antworten
  • extrapyramidal syndrome
  • hyperprolactinemia
  • drug dependence
  • postural hypotension

Frage 97

Frage
Antipsychotic with strong antipsychotic effect is:
Antworten
  • Chlorprothixene
  • Thioridazine
  • Haloperidol
  • Clozapine

Frage 98

Frage
Mode of action of benzodiazepines is:
Antworten
  • enhance the effectiveness of GABA
  • block of GABA receptors
  • block of sodium channels
  • activation of dopamine receptors

Frage 99

Frage
Adverse drug reactions of benzodiazepines are:
Antworten
  • seizures
  • tolerance and drug dependence
  • extrapyramidal side effects
  • ataxia

Frage 100

Frage
Antagonist of benzodiazepines is:
Antworten
  • Naloxone
  • Flumazenil
  • Chlorpromazine
  • Clozapine

Frage 101

Frage
Opioids are suitable for treatment of
Antworten
  • traumatic shock
  • acute myocardial infarction
  • headache
  • neuritis

Frage 102

Frage
Contraindications for the use of opioid analgesics:
Antworten
  • pregnancy, breastfeeding
  • diseases, associated with respiratory depression
  • head trauma and brain injury
  • traumatic shock

Frage 103

Frage
Specific morphine antagonist is:
Antworten
  • Flumazenil
  • Naloxone
  • Bemegrid
  • Protamin sulfas

Frage 104

Frage
Point out the correct statements for Pethidine (Lydol):
Antworten
  • has a spasmolytic effect on the smooth muscles
  • it is a stronger analgesic than morphine
  • has a shorter duration of action than morphine
  • can be used for neuroleptanaigesia

Frage 105

Frage
Opioid drug with a strong anti-tussive effect is:
Antworten
  • Tramadol
  • Pethidin
  • Morphine
  • Codeine

Frage 106

Frage
For analgesics-antipyretics is true:
Antworten
  • they affect normal body temperature
  • the antipyretic effect is clue to suppression of PgE synthesis in the hypothalamus
  • they lower only elevated body temperature (i.e. fever)
  • intensify heat diffusion

Frage 107

Frage
Adverse drug reactions of Metamizol (Analgin) are:
Antworten
  • allergic reactions
  • hyperthermla
  • agranulocytosis
  • red coloured urine

Frage 108

Frage
Pharmacological effects of Paracetamol are:
Antworten
  • antipyretic
  • anti-inflammatory
  • analgesic
  • antiplatelet

Frage 109

Frage
What are the therapeutic effects of NSAIDs:
Antworten
  • analgesic
  • anti-inflammatory
  • hypnotic
  • antipyretic

Frage 110

Frage
What is the mechanism of action of NSAiDs:
Antworten
  • inhibition of phosphodiesterases
  • blockade of dopamine receptors
  • inhibition of cyclooxygenase
  • inhibition of MAO

Frage 111

Frage
Pharmacological effects of salicylates are:
Antworten
  • anti-inflammatory
  • sedative
  • analgesic
  • antiplatelet

Frage 112

Frage
Which of the following drugs are selective COX-2 inhibitors:
Antworten
  • Aspirin
  • Celecoxib
  • Indomethacin
  • Meloxicam
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