Frage 1
Frage
Which of the following develop from somites?
Antworten
-
Axial skeleton
-
Appendicular skeleton
-
Axial muscles
-
Appendicular muscles
Frage 2
Frage
What is found in the centre of the developing embryo?
Antworten
-
Neural tube
-
Pairs of somites
-
Limb buds
-
Notochord
-
Sclerodome
Frage 3
Frage
Somites develop in pairs. True or false?
Frage 4
Frage
From which end do the pairs of somites develop?
Antworten
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Caudal end
-
Rostral end
-
Superior end
-
Inferior end
Frage 5
Frage
What is somite development controlled by?
Frage 6
Frage
Somites account for only a small amount of our body mass after development. True or false?
Frage 7
Frage
Which of the following are developed from the somites?
Antworten
-
Dermatome
-
Myotome
-
Sclerotome
-
Syndetome
-
Heptatome
-
Angiotome
Frage 8
Frage
What does the skin develop from?
Antworten
-
Dermatome
-
Myotome
-
Sclerotome
-
Syndetome
Frage 9
Frage
What does muscle develop from?
Antworten
-
Myotome
-
Dermatome
-
Scleratome
-
Syndetome
Frage 10
Frage
What does bone develop from?
Antworten
-
Sclerotome
-
Dermatome
-
Myotome
-
Syndetome
Frage 11
Frage
What do ligaments and tendons develop from?
Antworten
-
Syndetome
-
Dermatome
-
Myotome
-
Scleratome
Frage 12
Frage
What do somites induce?
Frage 13
Frage
How are vertebrae formed from the somites?
Antworten
-
From the caudal end of one somite and the cranial end of another
-
One somite goes onto create one vertebra
-
Two somites fuse across the neural tube to form a vertebral bone
-
Somites do not go onto form vertebrae
Frage 14
Frage
Which part of the somite is split into two by the development of the spinal nerve?
Antworten
-
Scleratome
-
Myotome
-
Dermatome
-
Syndetome
Frage 15
Frage
The scleratome of the first five somites goes onto create which bone?
Antworten
-
Occipital bone
-
Frontal bone
-
Temporal bone
-
Sphenoid bone
-
Parietal bone
Frage 16
Frage
The scleratome converges around the neural tube. True or false?
Frage 17
Frage
If the scleratome does not converge around the spinal cord completely what condition will the child have?
Antworten
-
Spina bifida
-
Pattau's syndrome
-
Scoliosis
-
Brevicollis
-
Kyphosis
Frage 18
Frage
Where in the developing embryo will the notochord be found?
Frage 19
Frage
Most of the notochord is removed during development, but it remains in one place. Where does it remain?
Antworten
-
Nucleus pulposis of the intervertebral disc
-
Annulus fibrosis of the intervertebral disc
-
In the dorsal root ganglion of spinal nerves
-
In the lining of the ventral median fissure of the spinal cord
Frage 20
Antworten
-
Lateral curvature of the spine
-
Reduced number of cervical vertebrae
-
Reduced number of thoracic vertebrae
-
Dorsal displacement of the spine
Frage 21
Frage
What is brevicollis?
Antworten
-
Reduced number of cervical vertebrae
-
Reduced number of thoracic vertebrae
-
Lumbar vertebrae of abnormally small size
-
Absence of a sacral bone
Frage 22
Frage
What do limb buds develop from?
Antworten
-
Lateral mesoderm and over-lying ectoderm
-
Medical mesoderm and ectoderm
-
Mesoderm and the ectoderm that is deep to it
-
Mesoderm only
Frage 23
Frage
What are limb buds controlled by?
Antworten
-
HOX genes
-
House-keeping genes
-
Chemical gradients
-
Somites
Frage 24
Frage
What develops from the limb buds?
Antworten
-
Appendicular skeleton
-
Appendicular muscles
-
Axial skeleton
-
Axial muscles
Frage 25
Frage
What are the three stages in limb bud development?
Frage 26
Frage
During limb bud patterning of the upper limb, which bone will develop first?
Antworten
-
Carpals
-
Ulna
-
Humerus
-
Scapula
Frage 27
Frage
What does digit patterning involve?
Antworten
-
Apoptosis of cells at the end of the limb bud
-
Coordinated outgrowth of cells to form digits
-
Necrosis of webbing between the newly developed digits
Frage 28
Frage
What are the names of the two signalling centres on the limb buds?
Antworten
-
Apical ectodermal ridge (AER)
-
Zone of polarising activity (ZPA)
-
Basal mesodermal dome (BMD)
-
Sclerotome signalling centre (SSC)
Frage 29
Frage
Which of the following is produced by the apical ectodermal ridge (AER)?
Frage 30
Frage
What is the function of the signalling molecules produced by the AER and the ZPA?
Antworten
-
Ensure the correct bones develop in the correct place
-
Ensure that apoptosis occurs where it is needed to
-
Ensure that the limb bud reaches it's full length
-
Ensure that any mutated cells are destroyed
-
Ensure that the limb bud develops in the correct direction by creating a chemical gradient
Frage 31
Frage
What is the function of FGF8 from the apical ectodermal ridge (AER)?
Antworten
-
Maintain proliferation in the progress zone
-
Prevent cell division anywhere other than the progress zone
-
Turn of proliferation in the progress zone when new cells are no longer required
Frage 32
Frage
What chemical signal controls the apoptosis that creates the fingers and the toes?
Antworten
-
BMP
-
SHH
-
FGF8
-
Sonic hedgehog
Frage 33
Frage
What will occur when apoptosis of the end of the limb bud does not occur?
Antworten
-
Syndactayly
-
Meromelia
-
Cleft hand or foot
Frage 34
Frage
What condition is BMP related to where the receptors are activated when BMP is not present?
Frage 35
Frage
What happens in fibrodysplasia ossificans progressivia?
Antworten
-
Tissues become progressively ossified when they shouldn't be
-
The ossification of tissues is progressively broken down
-
The body has an inflammatory reaction to tissue that are ossified
Frage 36
Antworten
-
The congenital absence of one or more limbs
-
The congenital absence of a part, but not all, of one or more limbs but with the presence of a hand or foot
-
A congenital deformity in which the hand or feet are closely attached to the torso with the limbs being under-developed
Frage 37
Antworten
-
Congenital absence of one or more limbs
-
Congenital absence of a part, but not all, of one or more limbs but with the presence of a hand or foot
-
A congenital deformity in which the hands or feet are closely attached to the torso, with the limbs being under-developed
Frage 38
Frage
What is phocomelia?
Antworten
-
A congenital deformity in which the hands or feet are closely attached to the torso, with the limbs being under-developed
-
The congenital absence of one or more limbs
-
The congenital absence of a part, but not all, of one or more limbs, but with the presence of a hand or foot
Frage 39
Frage
What drug is famously known to cause amelia, meromelia and phocomelia?
Antworten
-
Thalidomide
-
Methotrexate
-
Dexamethosone
-
Enalapril
-
Aspirin
Frage 40
Frage
What is ectrodactyly?
Antworten
-
Congenital absence of part or all of one or more fingers or toes
-
A condition in which a person has more than five fingers or toes on one, or each, of their hands or feet
-
A condition of having some or all of the fingers or toes partly or wholly united
Frage 41
Frage
All the normal elements of a limb are present in club foot or club hand. True or false?
Frage 42
Frage
Why are the dermatomes in an adult human rotated?
Antworten
-
Because of limb rotation that occurs during development
-
Because of limb rotation that occurs after birth
-
Because we a bipedal, not quadrupedal
-
Because the spinal nerve rotate during development
Frage 43
Frage
What condition affects one dermatome of skin?
Antworten
-
Shingles
-
Menigitis
-
Pityriasis rosea
-
Bell's palsy
-
Chicken pox
Frage 44
Frage
Why does shingles only affect one dermatome?
Antworten
-
Because the virus travels down one spinal nerve only
-
Because the immune cells in this area of skin have been destroyed
-
Because the virus is only present on the skin in this dermatome
Frage 45
Frage
What does the myotome go onto form?
Antworten
-
Epimere
-
Hypomere
-
Ectomere
-
Mesomere
-
Hypermere
Frage 46
Frage
The limb muscles develop from the...?
Antworten
-
Hypomere
-
Epimere
-
Hypermere
-
Ectomere
-
Mesomere
Frage 47
Frage
What does the epimere develop into?
Antworten
-
Dorsal muscles - i.e. muscles of the back
-
Limb muscles - i.e. flexors and extensors
-
Ventral muscles - i.e everything but the muscles of the back
Frage 48
Frage
Which of the following is bigger?
Frage 49
Frage
What goes onto supplies the muscles formed from the epimere?
Frage 50
Frage
What controls somite division?
Antworten
-
Signalling molecules produced by adjacent tissues
-
Signalling molecules produced by the neural tube
-
Signalling molecule produces by the notocord
-
Signalling molecules in the embryonic fluid
-
Hormones produced by the mother
Frage 51
Frage
What do myogenic factors do?
Antworten
-
Drive skeletal muscle-specific differentiation
-
Create a chemical gradient to direct muscle growth in the correct direction
-
Prevent abnormal muscle growth
Frage 52
Frage
Myogenic factors remain present after development. True or false?
Frage 53
Frage
What is the function of myogenic factors after development?
Antworten
-
Set aside stem cells for muscle repair
-
Prevent abnormal muscle growth
-
Prevent striation from being lost from the skeletal muscle
Frage 54
Frage
Signalling molecule BMP is also important in the attachment of the syndetome to bone and muscle so it can form tendons. True or false?
Frage 55
Frage
What are the name of the stem cells within mature skeletal muscle?
Antworten
-
Satellite cells
-
Basal cells
-
Myogenic repair cells
Frage 56
Frage
What neurotransmitter is present at the neuromuscular junction?
Antworten
-
Acetylcholine
-
Dopamine
-
Noradrenaline
-
GABA