3094603
Frage 1
Frage
What is the most common cancer in males?
Antworten
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Non Melanoma Skin Caner
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Prostrate cancer
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Lung cancer
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Colorectal
Frage 2
Frage
What is the most common cancer in females?
Antworten
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Breast cancer
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Non Melanoma Skin Cancer
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Lung cancer
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Colorectal cancer
Frage 3
Frage
How do Tobacco smoke and coal tar form cancer?
Antworten
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Forming aldehyde adducts
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Forming DNA adducts
Frage 4
Frage
Exposure to what substances increases the liver cancer incidence?
Antworten
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Aflatoxin B1 and Hepatitits B
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alcohol and tobacco
Frage 5
Frage
Protooncogene inheritance is classified as
Antworten
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Loss of function
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Gain of function
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Both
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None of the above
Frage 6
Frage
Tumor suppressor gene inheritance is classified as?
Antworten
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Loss of function
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Gain of function
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Both
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None of the above
Frage 7
Frage
In Familial cancer syndrome what is the gene that is mutated?
Antworten
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RET
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MET(HGFR)
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BCR
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ABL
Frage 8
Frage
In Hereditary renal papillary carcinoma what is the gene that is mutated?
Antworten
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MET (HGFR)
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RET
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ABL
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BCR
Frage 9
Frage
What is the translocation in follicular lymphoma
Antworten
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14:18
-
15:17
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9:22
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11:22
Frage 10
Frage
CML translocation is seen between what chromosomes?
Antworten
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9:22
-
15:17
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11:22
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14:18
Frage 11
Frage
What translocation is seen in Promyelocytic leukemia?
Antworten
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15:17
-
9:22
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11:22
-
14:18
Frage 12
Frage
Translocation in Ewing's Sarcoma?
Antworten
-
11:22
-
14:18
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15:17
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9:22
Frage 13
Frage
How does translocation cause cancer?
Antworten
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The novel product promotes proliferates like an oncogene
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It makes a transcription factor that promotes proliferation
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It makes a novel factor that inhibits apoptosis
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None of the above
Frage 14
Frage
N-MYC is amplified in what tumor?
Antworten
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Neuroblastoma
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Pheochromocytoma
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Wilms tumor
Frage 15
Frage
In Knudson's 2 hit model what are the mechanisms for the second hit?
Antworten
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Loss of heterozygosity
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Deletion
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recombination
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non-dysjunction
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All of the above
Frage 16
Frage
Which of the following is not inherited by Autosomal Dominance?
Antworten
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Retinoblasotma
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Li-Fraumeni Syndrome
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Hereditary Breast cancer
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Neurofibromatosis 1
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FAP / HNPCC
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None of the above
Frage 17
Frage
What are the mutations in FAP?
Antworten
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APC
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BCR
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ABL
Frage 18
Frage
What are the mutations in HNPCC?
Antworten
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MLH 1 and 3
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MSH 2 and 6
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PMS 1 and 2
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All of the above
Frage 19
Frage
Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta
Antworten
- True
- False
Frage 20
Frage
Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation
Antworten
- True
- False
Frage 21
Frage
Microsatellite instability/ replication error positive is seen in HNPCC - true or false
Antworten
- True
- False
Frage 22
Frage
What are the mutations that are seen in sporadic cancer?
Antworten
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PTEN
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TGFBR2
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SMAD4
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WT1
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All of the above
Frage 23
Frage
In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?
Antworten
- True
- False
Frage 24
Frage
In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?
Antworten
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p53
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RB
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myc
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none of the above
Frage 25
Frage
Bloom syndrome - DNA helicase deficiency - true or flase
Antworten
- True
- False
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