Cancer 2

Loss of WT-1 gene results in what cancer?

All of the following are Autosomal recessive cancer predisposition disorders except?

All of the following are features of fanconi anemia except

Glioblastoma multiforme is due to 100x expression of an miRNA true or false?

Translocation in Burkitt's lymphoma

All of the following are true statements except

HPV oncogenes E6 & E7 act by?

In which cells telomeres are renewed (by activation of telomerase)?

Replicative senescence is due to the absence of telomerase - true or false

TERC : reverse transcriptase and TERT : RNA template true or false

Upregulation of what gene upregulates telomerase

Telomerase reactivation in cancer is the initiating event true or false

Telomerase reactivation in cancer is an important step in cancer progression true or false

Which of the following receptors belong to RTK family (receptor tyrosine kinases)

Activated RTKs phosphorylate what effector proteins?

RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false

Her2/EGFR2 genes are amplified in 30% breast cancers true or false

RAS-Gap gene codes for neurofibromin (NF1) true or false

Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false

Tamoxifen is an estrogen receptor antagonist true or false

Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false

Flutamide and bicalutamide are androgen receptor antagonists true or false