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Assessment 1.2 Practice

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phar530 assessment 1.2 practice
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following drug substance properties is important for capsule size selection?
Antworten
  • Melting Point
  • Bulk density
  • Particle Size
  • Drug solubility

Frage 2

Frage
Which of the following is not part of Capsule Quality Control program
Antworten
  • Drug Content
  • Friability Test
  • Dissolution test
  • Fill Weight
  • Disintegration Test

Frage 3

Frage
The stability dating requirements of USP 795 for the extemporaneous compounding of capsules are
Antworten
  • 4 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products
  • 6 months if prepared from USP/NF ingredients or 50% of remaining expiration dating if prepared from commercial products
  • 2 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products
  • 6 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products

Frage 4

Frage
For human use, eight capsule sizes are available ranging from:
Antworten
  • the smallest No. 000 to the largest No.5.
  • the smallest No. 5 to the largest No. 000
  • the smallest No. 01 to the largest No. 08.
  • the smallest No. 1 to the largest No. 8

Frage 5

Frage
The coni-snap® hard gelatin capsules have a unique design that:
Antworten
  • Enables the two halves of the capsule shell to fit like a lock and key.
  • Enables the two halves of the capsule shell to be fit together by strong compression forces.
  • Enables the two halves of the capsule shell to be positively joined through locking grooves in the shell walls.
  • Enables the two halves of the capsule shell to be sealed with strong polymer adhesive

Frage 6

Frage
The USP content uniformity test for capsules specifies that:
Antworten
  • 9 out of 10 capsules are within 80% to 120% of labeled drug amount
  • 9 out of 10 capsules are within 85% to 115% of labeled drug amount
  • 9 out of 10 capsules are within 70% to 125% of labeled drug amount
  • 9 out of 10 capsules are within 75% to 125% of labeled drug amount

Frage 7

Frage
Substances that absorb moisture from the air to the extent that they liquefy are called
Antworten
  • Deliquescent
  • Levigated
  • Efflorescent
  • Hygroscopic

Frage 8

Frage
The following property is especially important in dermatologicals
Antworten
  • Rapid Disintegration
  • Content Uniformity
  • Nongrittiness of solid particles
  • Fast dissolution rate

Frage 9

Frage
Phenobartital divided powders have the advantage of
Antworten
  • Being dispensed in sifter-top containers
  • Spreading uniformly, and clinging to the skin upon application
  • Allowing physicians to prescribe a precise amount of the drug
  • Having no irritant properties when applied externally

Frage 10

Frage
Which of the following is FALSE regarding a dusting powder?
Antworten
  • Should flow easily, spread uniformly, and cling to the skin upon application
  • Would generally be dispensed in sifter-top containers
  • Must be able to have a systemic effect
  • Must be free from potential of causing local irritation

Frage 11

Frage
Which of the following is a natural emulsifying agent?
Antworten
  • Acacia
  • Brij
  • Benzakonium Chloride
  • Myrj
  • Sodium lauryl sulfate

Frage 12

Frage
The following powders when mixed are an example of a eutectic mixture
Antworten
  • Zinc oxide and glycerin
  • Phenol and talc powder
  • Camphor and menthol
  • Camphor and lactose

Frage 13

Frage
Metered inhalation aerosols containing micronized medicated powders typically have
Antworten
  • A particle size in the range of 18-26μm
  • A particle size in the range of 1-6μm
  • A particle size in the range of 12-18μm
  • A particle size in the range of 6-12μm

Frage 14

Frage
Which of the following is not a component of the Lacrimal Apparatus?
Antworten
  • Lacrimal Gland
  • Lacrimal Sac
  • Lacrimal Muscle
  • Lacrimal Ducts

Frage 15

Frage
Aqueous humor is produced by filtration of blood plasma in the region known as the:
Antworten
  • Choroid
  • Lacrimal Caruncle
  • Conjunctiva
  • Ciliary Body

Frage 16

Frage
Which of the following statements regarding the ophthalmic insert “Ocusert” is NOT true?
Antworten
  • Clinical acceptance of the device has been slow
  • It is a controlled delivery device for the drug pilocarpine
  • It is designed to dissolve completely in lacrimal fluids within a few days of insertion
  • It is more costly than traditional delivery systems such as solutions

Frage 17

Frage
Which layer(s) of the cornea offers the greatest barrier(s) to absorption into the eye for hydrophilic drugs?
Antworten
  • Endothelial layer
  • Epithelial layer
  • Stroma
  • b and c only

Frage 18

Frage
Cataracts are caused by
Antworten
  • clouding of the lens caused by clumping of crystallins.
  • loss of elasticity of the lens with age.
  • sloughing (peeling) of the posterior layers of the lens caused by various diseases
  • destruction of the cuboidal epithelial lining on the anterior surface of the lens.

Frage 19

Frage
To prevent possible corneal damage, ophthalmic formulations should be buffered in the pH range of:
Antworten
  • 4.5 to 10.5
  • 6.5 to 8.5
  • 3.5 to 11.5
  • 5.5 to 9.5

Frage 20

Frage
Which of the following is NOT an antioxidant that has been found appropriate for use in ophthalmic formulations?
Antworten
  • Sodium metabisulfite
  • Sodium Bisulfite
  • Thimerosal
  • Ethylenediaminetetraacetic acid

Frage 21

Frage
Particle size can influence:
Antworten
  • Penetrability of particles for inhalation (dry powder inhaler) for deposition deep in the respiratory tract.
  • Dissolution rate
  • Suspendability of suspensions
  • Uniformity of mixtures in powder dosage forms to ensure dose to dose content uniformity
  • All of the above

Frage 22

Frage
Below what pH will free phenobarbital begin to separate from a solution having an initial concentration of 2 g of sodium phenobarbital per 200 ml at 25 0C? The saturation solubility of phenobarbital is 0.005 M and the pKa =7.41 at 25 0C. Molecular weight of phenobarbital is 232 and sodium phenobarbital is 254.
Antworten
  • 8.45
  • 8.25
  • 8.35
  • 8.55
  • 8.65

Frage 23

Frage
The process of comminution by utilizing a SOLVENT that can be easily removed is termed:
Antworten
  • Geometric Dilution
  • Pulverization by intervention
  • Levigation
  • micronization

Frage 24

Frage
Which of the following is NOT an accurate characteristic of the rectum
Antworten
  • It is nonmotile in the resting state
  • It is approximately 15 to 20 cm in length
  • The mucosal lining contains Goblet cells which release collagen into the lumen.
  • When void of fecal matter it has a fluid content of 2 to 3 ml

Frage 25

Frage
Of the veins that drain the blood from the rectal area, which one(s) bypass the liver and deliver blood directly to the systemic circulation?
Antworten
  • The inferior and middle rectal veins
  • The inferior, middle and superior rectal veins
  • The inferior and superior rectal veins
  • The middle and superior rectal veins

Frage 26

Frage
The names of four drugs are given blow along with their corresponding density factors for cocoa butter. A. Aminophylline (1.1) B. Bismuth subnitrate (6.0) C. Menthol (0.7) D. Iodoform (4.0) For which drug would the greatest weight be required in order to displace 1 gram of coca butter from a formulation?
Antworten
  • A
  • B
  • C
  • D

Frage 27

Frage
Which of the following is NOT an advantage of drug dosing via the rectal route?
Antworten
  • Drugs are not exposed to GI membrane enzymatic activity
  • It can be used for unconscious or debilitated patients
  • Absorption from the rectal area is more rapid and predictable than from other regions of the GI tract
  • Hepatic first-pass metabolism may be avoided partially or completely

Frage 28

Frage
The maximum amount of solid that can normally be incorporated into a suppository is ______ of the blank weight.
Antworten
  • 50%
  • 40%
  • 30%
  • 10%

Frage 29

Frage
You desire to administer a drug rectally in order to obtain a rapid onset of action. Which of the following suppositories would you use?
Antworten
  • An oleaginous base containing the unionized form of the drug
  • An oleaginous base containing a salt form of the drug
  • A water miscible base containing the unionized form of the drug
  • A water miscible base containing a salt form of the drug

Frage 30

Frage
You are preparing a cocoa butter suppository and have added ingredients that have lowered the melting point below that of room temperature. In order to elevate the melting point of the mixture you will add:
Antworten
  • Beeswax
  • Chloral hydrate
  • Menthol
  • Camphor

Frage 31

Frage
The physical characteristics of Polyethylene glycol (PEG) polymers change with size. At what molecular weight do these polymers change from liquid to solid?
Antworten
  • 100
  • 1000
  • 10000
  • 500

Frage 32

Frage
You prepared and recorded the disintegration time for salicylic acid capsules in different pH media. Which statement is TRUE?
Antworten
  • The disintegration time of salicylic acid capsules was shortest in pH 7.4 buffer
  • The disintegration time of salicylic acid capsules was shortest in water
  • The disintegration time of salicylic acid capsules is longest in pH 1.2 buffer
  • The disintegration time of salicylic acid capsules was shortest in pH 1.2 buffer

Frage 33

Frage
Sedimentation rate of particles in suspension decreases with
Antworten
  • Increase in the viscosity of dispersed phase
  • Increase in the particle size
  • Decrease in the viscosity of dispersed phase
  • Decrease in the viscosity of dispersion medium
  • Increase in the viscosity of dispersion medium

Frage 34

Frage
Shelf-life is generally based on the time when the active drug is greater than ______ of the labeled.
Antworten
  • 99%
  • 95%
  • 90%
  • 85%

Frage 35

Frage
The pre-exponential factor, A, of the Arrhenius equation is representative of:
Antworten
  • the probability that any given collision will result in a reaction
  • the total number of collisions per unit time, whether they lead to a reaction or not
  • the fraction of molecules in the reaction that have energies higher than that of the activation energy, Ea.
  • the total number of collisions per unit time that result in a reaction

Frage 36

Frage
A solution has a shelf-life of 10 hours at a temperature of 35oC. Use the Q10 method to estimate the shelf-life if the solution is stored in a refrigerator at 5oC. Use a value of 3 for Q10.
Antworten
  • 30 hours
  • 90 hours
  • 150 hours
  • 270 hours

Frage 37

Frage
You are working in a pharmacy and are compounding a solid formulation in which the manufactured drug is the source of the active ingredient. The product’s expiration date is 16 months from today. What Beyond Use Date will you assign this formulation?
Antworten
  • 6 months
  • 4 months
  • 30 days
  • 14 days

Frage 38

Frage
A pharmacist compounding a fine dusting powder typically would triturate the components of the formulation in a mortar with a pestle and subsequently pass the mixture through a (n):
Antworten
  • #8 mesh sieve
  • #80 mesh sieve
  • #20 mesh sieve
  • #60 mesh sieve

Frage 39

Frage
Soft gelatin capsules are made of gelatin
Antworten
  • to which polysorbate 80 has been added
  • to which glycerin has been added
  • to which mineral oil has been added
  • to which camphor has been added

Frage 40

Frage
Which one of the following has the highest aqueous solubility?
Antworten
  • C6H5OH
  • C6H4(OH)2
  • C6H3Cl3
  • C6H5Cl
  • C6H3(OH)3

Frage 41

Frage
Which of the following is NOT a major factor affecting solubility?
Antworten
  • Temperatur
  • pH of the solution
  • Polarity of the solvent
  • Polarity of the solute
  • Moleculare weight of the solvent

Frage 42

Frage
Active transport processes include all of the following except for which one?
Antworten
  • Active transport of drug molecules may be saturated at high drug concentrations
  • Active transport moves drug molecules against a concentration gradient
  • active transport requires energy
  • Active transport follows fick's law of diffusion
  • Active transport is a carrier mediated transport system

Frage 43

Frage
When comparing an amorphous form of a drug to a crystalline form of a drug:
Antworten
  • Amorphous forms dissolve more quickly
  • crystalline forms are more pharmacologically active
  • Metastable forms are more clinically effective
  • Amorphous forms are more chemically stable

Frage 44

Frage
According to the FDA Biopharmaceutics classification system, the class III type compounds are those with:
Antworten
  • High solubility, low permiability
  • High solubility, high permeability
  • low solubility, low permeability
  • low solubility, high permeability

Frage 45

Frage
What imparts the pink color to Calamine USP
Antworten
  • FD&C red no3
  • Carmine
  • Zinc Oxide
  • Ferric Oxide

Frage 46

Frage
Chemicals of indeterminate quality would be labeled as
Antworten
  • USP/NF
  • ACS Reagent
  • Chemically Pure
  • Technical or commercial

Frage 47

Frage
this grade of ingredients is : High purity; conforms to minimum specifications set by the Reagent Chemicals Committee of the American Chemicals Society
Antworten
  • USP/NF
  • ACS Reagent
  • Chemically Pure
  • Technical or commercial

Frage 48

Frage
This grade of chemicals is :More refined than technical or commercial grade but still of unknown quality
Antworten
  • USP/NF
  • ACS Reagent
  • Chemically Pure
  • Technical or commercial

Frage 49

Frage
This grade of chemicals : Meets the minimum purity standards; and conforms to tolerances set by the United States Pharmacopeia/National Formulary for contaminants dangerous to health
Antworten
  • USP/NF
  • ACS Reagent
  • Chemically Pure
  • Technical or commercial

Frage 50

Frage
Which of the following is NOT true for crystal polymorphs?
Antworten
  • May have different solubility
  • May have different dissolution rates
  • May have different physical and chemical stability
  • May have different chemical structures
  • May have different melting points

Frage 51

Frage
Which condition usually increases the rate of drug dissolution from a tablet?
Antworten
  • Use of enteric coating
  • Use of the ionized or salt of the drug
  • Use of the free acid or free base form of the drug
  • Decrease surface area of the drug
  • Increase particle size of the drug

Frage 52

Frage
Which of the following is FALSE regarding inconsistencies in dissolution rates?
Antworten
  • Dose units within a batch typically give consistent dissolution results
  • dose units within a batch typically give inconsistent dissolution results
  • dissolution inconsistencies can occur between batches or products from the same manufacturer
  • Dissolution inconsistencies can occur between batches or products from different manufacturers

Frage 53

Frage
All of the following factors depend on the rate of active drug dissolution within the gastrointestinal content EXCEPT:
Antworten
  • Fraction of the administered dose that is bioavailable
  • Time after administration until therapeutic action begins
  • Intensity of systemic pharmacologic effects
  • site of action in the body

Frage 54

Frage
Which of the following is FALSE regarding the need for a dosage form?
Antworten
  • To provide for a safe and convenient delivery of accurate dosage
  • To conceal the bitter, salty, or offensive taste, or odor of a drug
  • To protect the drug substance from the destructive influences of atmospheric oxygen or humidity
  • To enhance the dissolution rate of a drug substance.

Frage 55

Frage
What is the minimum weighable quantity with no more than 5% error for a balance with a sensitivity requirement of 6mg?
Antworten
  • 300mg
  • 30mg
  • 120mg
  • 3mg

Frage 56

Frage
The Prescription balance needed for weighing chemicals is currently designated as a class ____ balance by the national bureau of standards
Antworten
  • I
  • II
  • III
  • P
  • Q

Frage 57

Frage
A Class III balance should have a sensitivity requirement of:
Antworten
  • 10mg
  • 5mg
  • 6mg
  • 2mg

Frage 58

Frage
All of the following are part of the compendial requirements for tablets according to USP/NF EXCEPT:
Antworten
  • Tablet Content Uniformity test
  • Tablet Weight Variation Test
  • Tablet Thickness Test
  • Tablet Dissolution test
  • Tablet Disintegration test

Frage 59

Frage
At the first sign of Angina attack the patient should reach out and:
Antworten
  • Apply Nitro ointment to the chest
  • Apply a Nitro patch to the skin
  • Swallow a sustained release 2.5 mg Nitro capsule
  • Place a sublingual Nitro tablet under the tongue

Frage 60

Frage
The requirements for tablet content uniformity are met if the amount of active ingredient in each dose unit is within the range:
Antworten
  • 95-105% of the label claim and the standard deviation less than 6%
  • 90-110% of the label claim with a standard deviation less than 6%
  • 85-115% of the label claim and a standard deviation of less than 6%
  • 80-120% of the label claim and a standard deviation of less than 6%

Frage 61

Frage
Which of the following excipients can NOT be used in the formulation of tetracycline antibiotics?
Antworten
  • Microcrystalline cellulose
  • starch
  • talc powder
  • Calcium Phosphate

Frage 62

Frage
The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet is known as
Antworten
  • Lamination
  • Picking
  • Slugging
  • Capping
  • Mottling

Frage 63

Frage
All of the following statements reflect the importance of in-vitro dissolution testing EXCEPT:
Antworten
  • It guides the formulation and product development towards product optimization
  • It is a requirement for regulatory approval of marketed products registered with the FDA
  • It is important for guiding the testing of class I BCS type compounds
  • Consistent dissolution testing ensures bioequivalence between batch to batch

Frage 64

Frage
Which of the following organic esters is commonly used in enteric coating of solid dosage forms?
Antworten
  • Phosphate
  • Tannate
  • Acrylate
  • Phthalate
  • Succinate

Frage 65

Frage
Which of the following is NOT a candidate for an extended release product?
Antworten
  • Drug with narrow therapeutic index
  • Drug administered in relatively small doses
  • Drug that exhibits neither slow nor fast rate of excretion
  • Drug must be absorbed/excreted at a moderate rate
  • Drug used in the treatment of chronic conditions

Frage 66

Frage
Which of the following products is an osmotic oral release system?
Antworten
  • Spansule Capsule
  • Glucotrol XL
  • Micro-K10 extencaps
  • Desoxyn gradument

Frage 67

Frage
What is a feature of Procardia XL tablets?
Antworten
  • Tablet remains intact in the stool
  • Rapid disintegration to quickly release components
  • Protect the drug from the acidic stomach environment
  • Fast dissolving of the outer core of the tablet allowing the drug dose to be immediately available
  • Orally disintegrating tablet which releases in the mouth within 1 minute

Frage 68

Frage
Tablets that are characterized by disintegrating or dissolving in the mouth within 1 minute are called:
Antworten
  • Effervescent Tablets
  • Enteric coated Tablets
  • Modified release tablets
  • Immediate release tablets
  • Rapidly dissolving Tablets

Frage 69

Frage
Which chapter in the USP/NF provides for the procedures and requirements for nonsterile type of compounding?
Antworten
  • 1075
  • 1163
  • 795
  • 797
  • 1160

Frage 70

Frage
In which of the following kinetic processes does the value of the half-life remain constant irrespective of time or amount of reactant?
Antworten
  • Second order
  • First order
  • Zero order
  • All of the above

Frage 71

Frage
You prepare 2 plots. One you plot ln(Y) vs time. One you plot log(Y) vs time. Both plots yield straight lines. For which of these plots is the negative slope the steepest?
Antworten
  • Plot of ln(Y) vs time
  • Plot of Log(Y) vs time
  • The slopes of the two lines are the same
  • The slopes depend on the amounts of Y present initially

Frage 72

Frage
The rate constant (k) is 0.08 moles/minute. If we begin the rxn with 10 moles of Y, how much Y will disappear in the first minute of the reaction
Antworten
  • 0.08 moles
  • 0.4 moles
  • 0.8 moles
  • 10 moles

Frage 73

Frage
A ________ Dispersion has particles that range in the diameter from 1nm to 0.5micron and that are visible in an electron microscope but not an ordinary optical microscope
Antworten
  • Molecular
  • Cellular
  • Coarse
  • Colloidal

Frage 74

Frage
Which of the following types of compounds would be least susceptible to degradation via oxidation
Antworten
  • Alcohols
  • Esters
  • Aldehydes
  • Molecules with unsaturated linkages

Frage 75

Frage
The most important cause of drug decomposition is
Antworten
  • Oxidation
  • Reduction
  • hydrolysis
  • condensation

Frage 76

Frage
How many half lives would it take for 90% of any initial concentration of a drug to disappear from a reaction vessel, assuming first order chemical kinetics?
Antworten
  • 6.7
  • 4.3
  • 2.7
  • 3.3

Frage 77

Frage
In which of the following kinetic processes is the rate constant the same as the rate?
Antworten
  • Zero-order
  • Second-order
  • Michaelis-Menten
  • first-order

Frage 78

Frage
When the concentration of the drug (Y) is low (Y<<K), the process will best be described by:
Antworten
  • Zero-order
  • First-order
  • Second-order
  • Unimolecularity

Frage 79

Frage
An Inert system is:
Antworten
  • Thermodynamically stable and kinetically stable
  • Thermodynamically unstable and kinetically unstable
  • Thermodynamically stable and kinetically unstable
  • Thermodynamically unstable and kinetically stable

Frage 80

Frage
Which kinetic process is linear
Antworten
  • Zero-order
  • First-order
  • Both A and B
  • Neither a nor B
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