3216761
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Quiz von shadow_spiers, aktualisiert more than 1 year ago
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Erstellt von shadow_spiers
vor mehr als 9 Jahre
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Frage 1
Frage
Which of the following is NOT an advantage of solution dosage form as compared to solid dosage form?
Antworten
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Greater Bioavailability
-
Ease of Transportation
-
Ease of Administration
-
Pediatric Use
Frage 2
Frage
Which of the following is true with regards to the solubility of a weak acid?
Antworten
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Solubility increases with decreasing pH
-
Solubility increases with increasing pH
-
Solubility decreases with increasing pH
-
Solubility remains constant with increasing pH
Frage 3
Frage
A novel compound dissolves in water and the solution becomes cold. Which of the following will further increase the solubility of this compound in water?
Antworten
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Decrease in temperature
-
Decreased amount of water
-
Increase in temperature
-
Increased amount of novel compound
Frage 4
Frage
__________ are dispersions of liquid drugs in liquid vehicles.
Antworten
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Suspension
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Emulsion
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Colloid
-
Gel
Frage 5
Frage
Which of the following has the least aqueous solubility
Antworten
-
CHCl3
-
CCl4
-
CH2Cl2
-
CH3Cl
Frage 6
Frage
Syrup is a concentrated alcoholic solution with sweetener and medicinal agent ?
Antworten
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True
-
False
Frage 7
Frage
Which of the following is not an example of Cosolvent system?
Antworten
-
Aromatic Elixir
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Iodine Tincture
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Acacia Syrup
-
Paregoric tincture
Frage 8
Frage
All of the following are advantages of Pharmaceutical solutions EXCEPT
Antworten
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Easier to swallow
-
Greater Bioavailability
-
More stable than solid dosage forms
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Homogenous uniform dosing is possible
Frage 9
Frage
The two MAJOR factors affecting solubility are?
Antworten
-
Temperature and agitation
-
pH and particle size
-
Polarity and agitation
-
Temperature and pH
Frage 10
Frage
To determine the ratio of buffer components to add to a solution to maintain a given pH you should use which equation?
Antworten
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pH= pKa + log (salt/acid)
-
pHmax = pKa + Log [(St-Sa)/Sa]
-
B= change in B/ change in pH
-
St= Sa(1+ [Ka/H])
Frage 11
Frage
All of the following are generally true about Organic Compound Solubility EXCEPT:
Antworten
-
More carbon atoms decrease the aqueous solubility
-
Halogens decrease solubility
-
Polar groups increase solubility
-
Low melting point indicates low solubility
Frage 12
Frage
Which of the following would be considered an ethanol/ water cosolvent system.
Antworten
-
Inverted syrup
-
Magic Mouthwash
-
Paregoric
-
Acacia Syrup
Frage 13
Frage
Which of the following is an example of a cosolvent?
Antworten
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Sodium Acetate
-
Oleic Acid
-
Sodium Benzoate
-
Saccharin Sodium
Frage 14
Frage
which of the following is NOT a force of attraction that affects dissolution?
Antworten
-
Ion-dipole
-
Van Der Waals
-
Hydrogen Bonding
-
Ionic Bonding
Frage 15
Frage
Sedimentation increases with_______?
Antworten
-
Particle size reduction
-
Increase in viscosity of dispersion medium
-
Increase in density of dispersed phase
-
Increase in density of dispersion medium
Frage 16
Frage
Which of the following is true when particle aize of an antibiotic powder is reduced from 50 micrometers to 5 micrometers?
Antworten
-
Higher surface area, Lower surface energy
-
Lower surface area,Higher surface energy
-
Lower surface area, Lower surface energy
-
Higher surface area, higher surface energy
Frage 17
Frage
Flocculation occurs due to stronger forces of attraction between the particles of a suspension.
Antworten
-
True
-
False
Frage 18
Frage
The Sedimentation Volume (F) for an ideal flocculated system is
Antworten
-
0.5
-
1.0
-
0.7
-
0.3
Frage 19
Frage
Which of the following is responsible for charge on a neutral particle surface when suspended in water?
Antworten
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Adsorption of OH-
-
Adsorption of H2O
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Particle wetting
-
Particle agglomeration
Frage 20
Frage
In an electrical double layer which layer is associated with the zeta potential?
Antworten
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Bulk layer
-
Diffuse layer
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Surface layer
-
Stern layer
Frage 21
Frage
Which of the following situations best represents a deflocculated system?
Antworten
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F=0.2
-
F=0.9
-
F=1.0
-
F=1.2
Frage 22
Frage
Flocculation is observed at extreme (+)ve and (-)ve values of zeta potential.
Antworten
-
True
-
False
Frage 23
Frage
The structured vehicle approach is applicable to both flocculated and deflocculated particles.
Antworten
-
True
-
False
Frage 24
Frage
Which of the following best represents the flow of flocculated suspension?
Antworten
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Newtonian Flow
-
Dilant Flow
-
Plastic Flow
-
Pseudoplastic Flow
Frage 25
Frage
In which of the following methods oil and emulsifier are mixed first followed by addition of water at once?
Antworten
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In-situ soap method
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English Method
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Auxiliary Method
-
Continental Method
-
Bottle Method
Frage 26
Frage
Skin permeation is a must for the component(s) of both medicated and non-medicated topical dosage forms.
Antworten
- True
- False
Frage 27
Frage
A major skin permeation pathway for small hydrophilic molecule is?
Antworten
-
Trans appendageal
-
Hair Follices
-
Transcellular
-
Intercellular
Frage 28
Frage
Absorption bases are associated with all of the following except?
Antworten
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Anhydrous
-
Absorb water
-
Water Washable
-
Hydrous
-
Occlusive
Frage 29
Frage
What is HFA?
Antworten
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Hydroflouroalkane
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Hydroflorine Association
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How Far Away
-
Happy Friend Association
Frage 30
Frage
Droplets decelerate as they leave the spray nozzle of a pressurized spray.
Antworten
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True
-
False
Frage 31
Frage
pDMIs can be sprayed in any orientation
Antworten
-
True
-
False
Frage 32
Frage
All medical Aerosol products contain a propellant
Antworten
-
True
-
False
Frage 33
Frage
All nasal sprays deliver the same dose independent of the orientation in which they are used
Antworten
-
True
-
False
Frage 34
Frage
Which of the following is NOT an advantage of a topical antibiotic sprayed on the skin rather than delivered by a cream.
Antworten
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Convenient
-
Minimal contamination of unused product
-
Accurate dose metering
-
No need to touch skin
-
Smaller particle size
Frage 35
Frage
If inhaled, particles with a diameter of 6 micrometers would be expected to penetrate the respiratory system to the level of the:
Antworten
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Bronchioles
-
Alveoli
-
Nasal Cavity
-
Throat (pharynx)
Frage 36
Frage
For which type(s) of aerosol system(s) will the pressure drop as the product is used?
Antworten
-
Compressed gas system
-
Three- phase system
-
Two-Phase system
-
B and C only
Frage 37
Frage
Which part of the valve assembly of an aerosol is responsible for preventing leakage of the formulation from the container?
Antworten
-
Mounting Cap
-
Actuator
-
Gasket
-
Housing
Frage 38
Frage
Which of the following is NOT an example of a "surface Spray" aerosol?
Antworten
-
Dermatological aerosols
-
Paint Sprays
-
Hair Sprays
-
Room deodorizers
Frage 39
Frage
What is the FDA recommended alcohol content limit in liquid OTC drug product for children 6-12 years?
Antworten
-
10%
-
1%
-
0.5%
-
5%
Frage 40
Frage
Which of the following descriptive terms of relative solubility includes 12.5% w/v strength?
Antworten
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Very soluble
-
Soluble
-
Slightly soluble
-
Freely Soluble
Frage 41
Frage
Which of the following groups on organic molecules will NOT increase water solubility?
Antworten
-
CH2F
-
NH2
-
COOH
-
SO3H
Frage 42
Frage
Which of the following is the pharmaceutical advantage of elixirs over syrups as liquid dosage forms?
Antworten
-
Contains less sugar
-
Dissolve ionized and unionized drugs
-
Provide faster drug absorption
-
Are better at masking the taste of drugs
Frage 43
Frage
Which of the following minimum alcohol percentages is required in medicated syrups to prevent microbial growth?
Antworten
-
5%
-
0.1%
-
15%
-
1%
Frage 44
Frage
Water cannot dissolve which of the following organic compounds by intermolecular hydrogen bonds?
Antworten
-
Esters
-
Alcohol
-
Acids
-
Hydrocarbons
Frage 45
Frage
Besides accurately and conveniently measuring dosage volume which of the following factors is important when making drug solutions for oral administration?
Antworten
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Color
-
Bioavailability
-
Stability
-
Taste
Frage 46
Frage
Which of the following is an example of an ingredient in an organogel?
Antworten
-
Sodium alginate
-
Hydrocarbon waxes
-
Polyethylene glycol
-
Carboxylmethylcellulose
Frage 47
Frage
Which of the following describes the action of a flocculating agent in drug suspensions?
Antworten
-
Enable loose interparticle attraction
-
Dissolve the suspended particles
-
Prevent interparticle attraction
-
Reduce the particle size
Frage 48
Frage
Which of the following is a correct statement regarding inhalation drug products (aerosols)?
Antworten
-
Each successive dose is slightly smaller as the pressure decreases with each actuation.
-
The total quantity of accurate dose from a metered dose inhaler is limited by depletion of the liquid phase of the propellant
-
The total quantity of accurate doses from a metered dose inhaler is limited by depletion of the active drug.
-
chlorofluorocarbon are federally prohibited for use as propellants
Frage 49
Frage
Which of the following blends of surfactants would favor a stable O/W emulsion?
Antworten
-
0.5 parts Myrj 45 + 0.5 parts Brij 30
-
0.4 parts Span40 +0.6 parts Tween 20
-
0.6 parts span60 +0.4 parts Tween80
-
0.7 parts span80 + 0.3 parts Tween60
Frage 50
Frage
Which of the following terms describes a fluid drug preparation that would increasingly flow more freely as it is agitated?
Antworten
-
Pseudoplastic
-
Plastic
-
Dilant
-
Thixotropic
Frage 51
Frage
Stoke's Law equation does NOT include which of the following factors?
Antworten
-
Interparticle Attraction
-
Fluid Density
-
Particle Diameter
-
Gravitational Constant
Frage 52
Frage
When treating a topical condition, all of the following are suitable criteria for selecting an ointment base for drug delivery EXCEPT:
Antworten
-
Degree of Occlusion provided
-
Therapeutic systemic blood levels of drug
-
Stability of drug in an ointment base
-
Characteristics of the skin that will be treated.
Frage 53
Frage
Which of the following is an example of a water soluble base
Antworten
-
White ointment USP
-
Lanolin USP
-
Polyehtylene Glycol Ointment USP
-
Hydrophillic Ointment USP
Frage 54
Frage
Which of the following is NOT an appropriate pharmacist counseling point to a patient before applying ophthalmic ointment?
Antworten
-
Tip of the tube should be placed in gentle contact with the conjunctival sac
-
Patient should wash and dry hands before application
-
Improperly handled ophthalmic products can lead to eye infection
-
After application blurred vision is normal and will likely occur
Frage 55
Frage
Which of the following is FALSE regarding levigating agents which are used to reduce drug particle size?
Antworten
-
Glycerin is an appropriate levigating agent for O/W bases
-
The levigating agent must be physically and chemically compatible with the drug and the ointment base
-
The drug for levigation should be soluble in the liquid used as the levegating agent
-
Mineral oil is a good levigating agent for W/O ointment bases
Frage 56
Frage
Which of the following TDDS products is permitted to be cut into smaller pieces for patient specific therapy?
Antworten
-
Nitro-Dur
-
Nicoderm
-
Duragesic
-
Fentanyl Patch
-
All of the above
-
None of the above
Frage 57
Frage
All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT:
Antworten
-
Full hydration of stratum corneum
-
A high aqueous solubility of the drug
-
Molecular weight of drug of about 100-400
-
A high partition coefficient of the drug
Frage 58
Frage
Wearing a TDDS for longer than the approved duration can result in unsafe plasma drug concentration
Antworten
-
True
-
False
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