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Quiz von Zainab Hassoun, aktualisiert more than 1 year ago
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Erstellt von Zainab Hassoun
vor mehr als 8 Jahre
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Frage 1
Frage
Select all that apply. Which of the following are β-lactamase penicillins?
Antworten
-
Ampicillin
-
Ticarcillin
-
Methicillin
-
Piperacillin
-
Nafcillin
-
Amoxicillin
Frage 2
Frage
What does PBP1A bind to?
Antworten
-
Transpeptidase
-
Carboxypeptidase
-
Endopeptidase
Frage 3
Frage
Penicillin G is stable in gastric acid.
Antworten
- True
- False
Frage 4
Frage
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Antworten
-
Penicillin G
-
Nafcillin
-
Ampicillin
-
Piperacillin
-
Amoxicillin
-
All of the above
Frage 5
Frage
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Antworten
-
hyperkalemia
Frage 6
Frage
Select all that apply. The mechanism of action for penicillins are:
Antworten
-
concentration dependent bactericidal action
-
time dependent bactericidal action
-
works best against rapidly dividing bacteria
-
works best against slowly dividing bacteria
-
inhibits transpeptidase activity of PBP3
Frage 7
Frage
Which of the following cause neutropenia?
Antworten
-
Penicillin V
-
Piperacillin
-
Penicillin G
-
Amoxicillin-Clavulanic Acid Combo
-
Vancomycin
-
A, B, and D
-
A and C
-
B, C, and E
Frage 8
Frage
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Antworten
-
Binds to ribosome 30s to prohibit protein synthesis
-
Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
-
Inhibits the cross-linkages between the peptidoglycan polymer strands
-
Disrupts the integrity of the cell membrane by displacing calcium and magnesium
Frage 9
Frage
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Antworten
-
Cephalosporins
-
Macrolides
-
Metronidazole
-
Tetracyclines
Frage 10
Frage
Penicillins are narrow spectrum drugs
Antworten
- True
- False
Frage 11
Frage
Select all of the bactericidal antibiotics.
Antworten
-
Macrolides
-
Penicillin
-
Tetracycline
-
Cephalexin
-
Aminoglycosides
-
Clindamycin
Frage 12
Frage
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Antworten
-
Stevens Johnsons
-
Superinfection
-
Teratology
-
Increased effects of oral contraceptives
Frage 13
Frage
Which of the following is incorrect regarding Penicillin G/Penicillin V
Antworten
-
Used for mixed aerobic-anaerobic infections
-
Used against gram positive and gram negative bacteria
-
One of these two can be used for treatment of Rheumatic fever
-
These are all correct
Frage 14
Frage
Which of the following is not an antistaphylococcal penicillin?
Antworten
-
Amoxicillin
-
Methicillin
-
Nafcillin
-
These are all antistaphylococcal penicillins
Frage 15
Frage
Penicillins work by inhibiting with enzyme?
Antworten
-
Integrase
-
Peptidyl transferase
-
Transpeptidase
-
Transcriptase
Frage 16
Frage
Penicillin V is administered by IV only
Antworten
- True
- False
Frage 17
Frage
Which of the following is NOT a possible adverse effect from penicillins?
Antworten
-
Allergy
-
Phlebitis
-
Fungal overgrowth
-
Hemolytic anemia
Frage 18
Frage
Which of the following is true regarding aminopenicillins?
Antworten
-
Resistant to beta lactamases
-
Narrow spectrum
-
Ampicillin has less side effects than amoxicillin
-
Effective against gonorrhea and meningitis
Frage 19
Frage
Select the following that are ineffective against beta lactamases:
Antworten
-
Penicillin V
-
Penicillin G
-
Dicloxacillin
-
Amoxicillin
Frage 20
Frage
Which of the following best represents first generation cephalosporins?
Antworten
-
Includes Cefotaxime and Ceftriaxone
-
Used for UTI (urinary tract infections) and soft tissue abscesses
-
Effective against Klebsiella and H influenza
-
Used for treatment of community-acquired pneumonia
Frage 21
Frage
Which of the following best describes the second generation of cephalosporins?
Antworten
-
Drug of choice for surgical prophylaxis
-
Used to treat meningitis
-
Includes the drug Cefuroxime
-
Includes the drug Cefepime
Frage 22
Frage
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Antworten
- True
- False
Frage 23
Frage
Tetracyclines are broad spectrum antibiotics
Antworten
- True
- False
Frage 24
Frage
Which of the following best matches the mechanism of tetracyclines?
Antworten
-
Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
-
Becomes mechanically reduced to toxic metabolite, interacting with DNA
-
Binds to 50s subunit, preventing binding of tRNA to mRNA
-
Binds to 30s subunit, preventing binding of tRNA to mRNA
Frage 25
Frage
Which of the following are targeted by tetracyclines?
Antworten
-
Rickettsia
-
MRSA infections
-
P. vivax malaria
-
All are targeted by tetracyclines
Frage 26
Frage
Which of the following is INCORRECT regarding macrolides?
Antworten
-
Broad spectrum
-
Used as an alternative for patients allergic to penicillins
-
Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
-
Kills gram positive and gram negative bacteria
Frage 27
Frage
Which of the following is incorrect regarding Chloramphenicol?
Antworten
-
It is bacteriostatic
-
Binds to 50s ribosome
-
Can be used to treat typhoid fever
-
Can be used for Neisseria gonorrhea
Frage 28
Frage
Chloramphenicol can cause gray baby syndrome.
Antworten
- True
- False
Frage 29
Frage
Which of the following is NOT a use for Clindamycin?
Antworten
-
Pseudomembranous colitis
-
Anthrax
-
Toxic shock syndrome
-
Odontogenic infection
Frage 30
Frage
Which of the following is NOT a concern for use of Clindamycin?
Antworten
-
Neuromuscular block
-
Skin rashes
-
Pseudomembranous colitis
-
Fulminant hepatic necrosis
Frage 31
Frage
What is the clinical use of sulfonamides?
Antworten
-
Skin infections
-
UTI (urinary tract infections)
-
Alternative for patients allergic to penicillins
-
Pseudomembranous colitis
Frage 32
Frage
Sulfonamide is a structural analog of DFHR
Antworten
- True
- False
Frage 33
Frage
Sulfonamides can cause which of the following adverse effects?
Antworten
-
Photosensitivity
-
Pseudomembranous colitis
-
Neutropenia
-
Seizures
Frage 34
Frage
Clotrimazole can be used for UTI (urinary tract infections)
Antworten
- True
- False
Frage 35
Frage
How do fluoroquinolones kill bacteria?
Antworten
-
They bind to topoisomerase-DNA complexes and form an inactive complex
-
They bind to bacterial ribosomes 30s
-
They inhibit transpeptidases
-
They compromise the integrity of the bacterial cell membrane
Frage 36
Frage
Which of the following can cause Red Man Syndrome?
Antworten
-
Penicillin
-
Erythromycin
-
Vancomycin
-
Sulfamethoxazole
Frage 37
Frage
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Antworten
-
nephrotoxicity
-
vestibular toxicity
-
tooth discoloration
-
cochlear toxicity
Frage 38
Frage
Which of the following cannot be used to treatment of MRSA?
Antworten
-
Linezolid
-
Vancomycin
-
Streptogramins
-
Clindamycin
Frage 39
Frage
MRSA is resistant to ALL penicillins and cephalosporins
Antworten
- True
- False
Frage 40
Frage
Which of the following does NOT increase risk of nephrotoxicity?
Antworten
-
Aminoglycosides
-
Amphoterecin B
-
Cisplatin
-
Macrolides
Frage 41
Frage
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Antworten
- True
- False
Frage 42
Frage
What type of fungal infection does nystatin treat?
Antworten
-
Cryptococcal meningitis
-
Candida infections
-
Histoplasmosis
-
Asperillosis
Frage 43
Frage
Choose all of the trizoles.
Antworten
-
Ketoconazole
-
Itraconazole
-
Fluconazole
-
Voriconazole
-
Miconazole
-
Clotrimazole.
Frage 44
Frage
What is the correct mechanism of azoles?
Antworten
-
Disrupts microtubule function and inhibits dermatophyte growth
-
Binds to membrane Ergosterol
-
Inhibits viral DNA polymerase
-
Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane
Frage 45
Frage
Which of the following is NOT an adverse effect of Azoles
Antworten
-
Steven Johnson
-
Increased levels of warfarin
-
Decreased fluconazole levels with isoniazid
-
Nephrotoxicity
Frage 46
Frage
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Antworten
-
Terbinafine
-
Griseofulvin
-
Echinocandins
-
Ketoconazole
Frage 47
Frage
Which of the following antifungals is used for onychomychosis and tinea?
Antworten
-
Griseofulvin
-
Terbinafine
-
Echinocandins
-
Ketoconazole
Frage 48
Frage
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Antworten
-
Acyclovir
-
Ganciclovir
-
Raltegravir
-
Retrovir
Frage 49
Frage
Ganciclovir causes myelosuppression
Antworten
- True
- False
Frage 50
Frage
What is the therapeutic use for Penicillin?
Antworten
-
Drug of choice for streptococci, pneumococcal, and staphylococcal infections
-
Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
-
Treatment of a broad range of gram positive and gram negative organisms
-
Treatment of patients who are unable to tolerate penicillins
Frage 51
Frage
What is the pharmacological class for Penicillin G?
Antworten
-
Aminoglycoside, protein synthesis inhibitor
-
Fluroquinolone, bacterial DNA synthesis inhibitor
-
Natural penicillin, cell wall inhibitor, beta lactam
-
Mycolic acid inhibitor
Frage 52
Frage
What is the pharmacological class of Cefotaxime?
Antworten
-
Beta lactam antibiotic, cell wall inhibitor
-
Tetracycline, protein synthesis inhibitor
-
Macrolide, protein synthesis inhibitor
Frage 53
Frage
Mechanism of action for Cefotaxime?
Antworten
-
Inhibits cell wall synthesis
-
Inhibits bacterial protein synthesis and prevents replication
-
Inhibits synthesis of mycolic acid
Frage 54
Frage
Tetracycline mechanism of action?
Antworten
-
Inhibits bacterial protein synthesis and prevents cell replication
-
Inhibits bacterial gyrase
-
Inhibits cell wall synthesis
Frage 55
Frage
What is the pharmacologic class for erythromycin?
Antworten
-
Macrolide, protein synthesis inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Beta lactam antibiotic
Frage 56
Frage
What is the mechanism of action for erythromycin?
Antworten
-
Inhibits protein synthesis
-
Inhibits cell wall synthesis
-
Binds to peptidoglycan
-
Inhibits bacterial protein synthesis and prevents cell replication
Frage 57
Frage
What is the pharmacologic class for gentamicin?
Antworten
-
Fluoroquinolone
-
Sulfonamide, folic acid inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Mycolic acid inhibitor
Frage 58
Frage
What is the mechanism of action for Gentamicin?
Antworten
-
Inhibits bacterial metabolism of folic acid
-
Inhibits protein synthesis, disrupting cell membrane and killing bacteria
-
Inhibits synthesis of mycolic acids
-
Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error
Frage 59
Frage
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Antworten
-
Trimetoprim-sulfamethoxazole
-
Ciprofloxacin
-
Isoniazid
-
Gentamicin
Frage 60
Frage
What is the pharmacological class and mechanism of action for ciprofloxacin?
Antworten
-
Fluoroquinolone, inhibits bacterial DNA gyrase
-
Mycolic acid inhibitor, inhibits mycolic acid
-
Aminoglycoside, inhibits protein synthesis
-
Sulfonamide, inhibits bacteiran metabolism of folic acid
Frage 61
Frage
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Antworten
-
Ciprofloxacin
-
Gentamicin
-
Penicillin
-
Trimethoprim-sulfamethoxazole
Frage 62
Frage
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Antworten
-
fluroquinolone, inhibits bacterial DNA gyrase
-
sulfonamide, inhibits bacterial metabolism of folic acid
-
aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria
Frage 63
Frage
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Antworten
-
Mebendazole
-
Amphotericin B
-
Fluconazole
-
Cloroquine
Frage 64
Frage
What is the mechanism of action for Mebendazole?
Antworten
-
Concentrates in food vacuoles of plasmodium residing in red blood cells
-
Inhibits microtubule formation and glucose uptake
-
Binds to ergosterol in fungal cell membranes and causes them to leak
-
Interferes with ergosterol synthesis
Frage 65
Frage
What is the therapeutic class for Amphotericin B?
Antworten
-
Antihelminth
-
Antifungal
-
Antifungal (systemic)
-
Antimalarial
Frage 66
Frage
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Antworten
-
Fluconazole
-
Cloroquine
-
Mebendazole
-
Amphotericin B
Frage 67
Frage
Select all the following drugs that are polyenes.
Antworten
-
Amphotericin B
-
Echinocandin
-
Griseofulvin
-
Nystatin
Frage 68
Frage
What is the therapeutic class for the drug Fluconazole?
Antworten
-
Antihelminth
-
Antifungal
-
Antibacterial
-
Antiviral
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