Antihelminths/Antibacterials/Antifungal/Antiviral/Antimicrobial Susceptibility Testing

Beschreibung

Let's f*cking do this
Zainab Hassoun
Quiz von Zainab Hassoun, aktualisiert more than 1 year ago
Zainab Hassoun
Erstellt von Zainab Hassoun vor etwa 9 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Select all that apply. Which of the following are β-lactamase penicillins?
Antworten
  • Ampicillin
  • Ticarcillin
  • Methicillin
  • Piperacillin
  • Nafcillin
  • Amoxicillin

Frage 2

Frage
What does PBP1A bind to?
Antworten
  • Transpeptidase
  • Carboxypeptidase
  • Endopeptidase

Frage 3

Frage
Penicillin G is stable in gastric acid.
Antworten
  • True
  • False

Frage 4

Frage
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Antworten
  • Penicillin G
  • Nafcillin
  • Ampicillin
  • Piperacillin
  • Amoxicillin
  • All of the above

Frage 5

Frage
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Antworten
  • hyperkalemia

Frage 6

Frage
Select all that apply. The mechanism of action for penicillins are:
Antworten
  • concentration dependent bactericidal action
  • time dependent bactericidal action
  • works best against rapidly dividing bacteria
  • works best against slowly dividing bacteria
  • inhibits transpeptidase activity of PBP3

Frage 7

Frage
Which of the following cause neutropenia?
Antworten
  • Penicillin V
  • Piperacillin
  • Penicillin G
  • Amoxicillin-Clavulanic Acid Combo
  • Vancomycin
  • A, B, and D
  • A and C
  • B, C, and E

Frage 8

Frage
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Antworten
  • Binds to ribosome 30s to prohibit protein synthesis
  • Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
  • Inhibits the cross-linkages between the peptidoglycan polymer strands
  • Disrupts the integrity of the cell membrane by displacing calcium and magnesium

Frage 9

Frage
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Antworten
  • Cephalosporins
  • Macrolides
  • Metronidazole
  • Tetracyclines

Frage 10

Frage
Penicillins are narrow spectrum drugs
Antworten
  • True
  • False

Frage 11

Frage
Select all of the bactericidal antibiotics.
Antworten
  • Macrolides
  • Penicillin
  • Tetracycline
  • Cephalexin
  • Aminoglycosides
  • Clindamycin

Frage 12

Frage
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Antworten
  • Stevens Johnsons
  • Superinfection
  • Teratology
  • Increased effects of oral contraceptives

Frage 13

Frage
Which of the following is incorrect regarding Penicillin G/Penicillin V
Antworten
  • Used for mixed aerobic-anaerobic infections
  • Used against gram positive and gram negative bacteria
  • One of these two can be used for treatment of Rheumatic fever
  • These are all correct

Frage 14

Frage
Which of the following is not an antistaphylococcal penicillin?
Antworten
  • Amoxicillin
  • Methicillin
  • Nafcillin
  • These are all antistaphylococcal penicillins

Frage 15

Frage
Penicillins work by inhibiting with enzyme?
Antworten
  • Integrase
  • Peptidyl transferase
  • Transpeptidase
  • Transcriptase

Frage 16

Frage
Penicillin V is administered by IV only
Antworten
  • True
  • False

Frage 17

Frage
Which of the following is NOT a possible adverse effect from penicillins?
Antworten
  • Allergy
  • Phlebitis
  • Fungal overgrowth
  • Hemolytic anemia

Frage 18

Frage
Which of the following is true regarding aminopenicillins?
Antworten
  • Resistant to beta lactamases
  • Narrow spectrum
  • Ampicillin has less side effects than amoxicillin
  • Effective against gonorrhea and meningitis

Frage 19

Frage
Select the following that are ineffective against beta lactamases:
Antworten
  • Penicillin V
  • Penicillin G
  • Dicloxacillin
  • Amoxicillin

Frage 20

Frage
Which of the following best represents first generation cephalosporins?
Antworten
  • Includes Cefotaxime and Ceftriaxone
  • Used for UTI (urinary tract infections) and soft tissue abscesses
  • Effective against Klebsiella and H influenza
  • Used for treatment of community-acquired pneumonia

Frage 21

Frage
Which of the following best describes the second generation of cephalosporins?
Antworten
  • Drug of choice for surgical prophylaxis
  • Used to treat meningitis
  • Includes the drug Cefuroxime
  • Includes the drug Cefepime

Frage 22

Frage
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Antworten
  • True
  • False

Frage 23

Frage
Tetracyclines are broad spectrum antibiotics
Antworten
  • True
  • False

Frage 24

Frage
Which of the following best matches the mechanism of tetracyclines?
Antworten
  • Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
  • Becomes mechanically reduced to toxic metabolite, interacting with DNA
  • Binds to 50s subunit, preventing binding of tRNA to mRNA
  • Binds to 30s subunit, preventing binding of tRNA to mRNA

Frage 25

Frage
Which of the following are targeted by tetracyclines?
Antworten
  • Rickettsia
  • MRSA infections
  • P. vivax malaria
  • All are targeted by tetracyclines

Frage 26

Frage
Which of the following is INCORRECT regarding macrolides?
Antworten
  • Broad spectrum
  • Used as an alternative for patients allergic to penicillins
  • Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
  • Kills gram positive and gram negative bacteria

Frage 27

Frage
Which of the following is incorrect regarding Chloramphenicol?
Antworten
  • It is bacteriostatic
  • Binds to 50s ribosome
  • Can be used to treat typhoid fever
  • Can be used for Neisseria gonorrhea

Frage 28

Frage
Chloramphenicol can cause gray baby syndrome.
Antworten
  • True
  • False

Frage 29

Frage
Which of the following is NOT a use for Clindamycin?
Antworten
  • Pseudomembranous colitis
  • Anthrax
  • Toxic shock syndrome
  • Odontogenic infection

Frage 30

Frage
Which of the following is NOT a concern for use of Clindamycin?
Antworten
  • Neuromuscular block
  • Skin rashes
  • Pseudomembranous colitis
  • Fulminant hepatic necrosis

Frage 31

Frage
What is the clinical use of sulfonamides?
Antworten
  • Skin infections
  • UTI (urinary tract infections)
  • Alternative for patients allergic to penicillins
  • Pseudomembranous colitis

Frage 32

Frage
Sulfonamide is a structural analog of DFHR
Antworten
  • True
  • False

Frage 33

Frage
Sulfonamides can cause which of the following adverse effects?
Antworten
  • Photosensitivity
  • Pseudomembranous colitis
  • Neutropenia
  • Seizures

Frage 34

Frage
Clotrimazole can be used for UTI (urinary tract infections)
Antworten
  • True
  • False

Frage 35

Frage
How do fluoroquinolones kill bacteria?
Antworten
  • They bind to topoisomerase-DNA complexes and form an inactive complex
  • They bind to bacterial ribosomes 30s
  • They inhibit transpeptidases
  • They compromise the integrity of the bacterial cell membrane

Frage 36

Frage
Which of the following can cause Red Man Syndrome?
Antworten
  • Penicillin
  • Erythromycin
  • Vancomycin
  • Sulfamethoxazole

Frage 37

Frage
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Antworten
  • nephrotoxicity
  • vestibular toxicity
  • tooth discoloration
  • cochlear toxicity

Frage 38

Frage
Which of the following cannot be used to treatment of MRSA?
Antworten
  • Linezolid
  • Vancomycin
  • Streptogramins
  • Clindamycin

Frage 39

Frage
MRSA is resistant to ALL penicillins and cephalosporins
Antworten
  • True
  • False

Frage 40

Frage
Which of the following does NOT increase risk of nephrotoxicity?
Antworten
  • Aminoglycosides
  • Amphoterecin B
  • Cisplatin
  • Macrolides

Frage 41

Frage
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Antworten
  • True
  • False

Frage 42

Frage
What type of fungal infection does nystatin treat?
Antworten
  • Cryptococcal meningitis
  • Candida infections
  • Histoplasmosis
  • Asperillosis

Frage 43

Frage
Choose all of the trizoles.
Antworten
  • Ketoconazole
  • Itraconazole
  • Fluconazole
  • Voriconazole
  • Miconazole
  • Clotrimazole.

Frage 44

Frage
What is the correct mechanism of azoles?
Antworten
  • Disrupts microtubule function and inhibits dermatophyte growth
  • Binds to membrane Ergosterol
  • Inhibits viral DNA polymerase
  • Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane

Frage 45

Frage
Which of the following is NOT an adverse effect of Azoles
Antworten
  • Steven Johnson
  • Increased levels of warfarin
  • Decreased fluconazole levels with isoniazid
  • Nephrotoxicity

Frage 46

Frage
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Antworten
  • Terbinafine
  • Griseofulvin
  • Echinocandins
  • Ketoconazole

Frage 47

Frage
Which of the following antifungals is used for onychomychosis and tinea?
Antworten
  • Griseofulvin
  • Terbinafine
  • Echinocandins
  • Ketoconazole

Frage 48

Frage
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Antworten
  • Acyclovir
  • Ganciclovir
  • Raltegravir
  • Retrovir

Frage 49

Frage
Ganciclovir causes myelosuppression
Antworten
  • True
  • False

Frage 50

Frage
What is the therapeutic use for Penicillin?
Antworten
  • Drug of choice for streptococci, pneumococcal, and staphylococcal infections
  • Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
  • Treatment of a broad range of gram positive and gram negative organisms
  • Treatment of patients who are unable to tolerate penicillins

Frage 51

Frage
What is the pharmacological class for Penicillin G?
Antworten
  • Aminoglycoside, protein synthesis inhibitor
  • Fluroquinolone, bacterial DNA synthesis inhibitor
  • Natural penicillin, cell wall inhibitor, beta lactam
  • Mycolic acid inhibitor

Frage 52

Frage
What is the pharmacological class of Cefotaxime?
Antworten
  • Beta lactam antibiotic, cell wall inhibitor
  • Tetracycline, protein synthesis inhibitor
  • Macrolide, protein synthesis inhibitor

Frage 53

Frage
Mechanism of action for Cefotaxime?
Antworten
  • Inhibits cell wall synthesis
  • Inhibits bacterial protein synthesis and prevents replication
  • Inhibits synthesis of mycolic acid

Frage 54

Frage
Tetracycline mechanism of action?
Antworten
  • Inhibits bacterial protein synthesis and prevents cell replication
  • Inhibits bacterial gyrase
  • Inhibits cell wall synthesis

Frage 55

Frage
What is the pharmacologic class for erythromycin?
Antworten
  • Macrolide, protein synthesis inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Beta lactam antibiotic

Frage 56

Frage
What is the mechanism of action for erythromycin?
Antworten
  • Inhibits protein synthesis
  • Inhibits cell wall synthesis
  • Binds to peptidoglycan
  • Inhibits bacterial protein synthesis and prevents cell replication

Frage 57

Frage
What is the pharmacologic class for gentamicin?
Antworten
  • Fluoroquinolone
  • Sulfonamide, folic acid inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Mycolic acid inhibitor

Frage 58

Frage
What is the mechanism of action for Gentamicin?
Antworten
  • Inhibits bacterial metabolism of folic acid
  • Inhibits protein synthesis, disrupting cell membrane and killing bacteria
  • Inhibits synthesis of mycolic acids
  • Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error

Frage 59

Frage
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Antworten
  • Trimetoprim-sulfamethoxazole
  • Ciprofloxacin
  • Isoniazid
  • Gentamicin

Frage 60

Frage
What is the pharmacological class and mechanism of action for ciprofloxacin?
Antworten
  • Fluoroquinolone, inhibits bacterial DNA gyrase
  • Mycolic acid inhibitor, inhibits mycolic acid
  • Aminoglycoside, inhibits protein synthesis
  • Sulfonamide, inhibits bacteiran metabolism of folic acid

Frage 61

Frage
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Antworten
  • Ciprofloxacin
  • Gentamicin
  • Penicillin
  • Trimethoprim-sulfamethoxazole

Frage 62

Frage
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Antworten
  • fluroquinolone, inhibits bacterial DNA gyrase
  • sulfonamide, inhibits bacterial metabolism of folic acid
  • aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria

Frage 63

Frage
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Antworten
  • Mebendazole
  • Amphotericin B
  • Fluconazole
  • Cloroquine

Frage 64

Frage
What is the mechanism of action for Mebendazole?
Antworten
  • Concentrates in food vacuoles of plasmodium residing in red blood cells
  • Inhibits microtubule formation and glucose uptake
  • Binds to ergosterol in fungal cell membranes and causes them to leak
  • Interferes with ergosterol synthesis

Frage 65

Frage
What is the therapeutic class for Amphotericin B?
Antworten
  • Antihelminth
  • Antifungal
  • Antifungal (systemic)
  • Antimalarial

Frage 66

Frage
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Antworten
  • Fluconazole
  • Cloroquine
  • Mebendazole
  • Amphotericin B

Frage 67

Frage
Select all the following drugs that are polyenes.
Antworten
  • Amphotericin B
  • Echinocandin
  • Griseofulvin
  • Nystatin

Frage 68

Frage
What is the therapeutic class for the drug Fluconazole?
Antworten
  • Antihelminth
  • Antifungal
  • Antibacterial
  • Antiviral
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