Zusammenfassung der Ressource
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Which drugs are used for glaucoma
[blank_start]Pilocarpine[blank_end]
[blank_start]Carbachol[blank_end]
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Pilocarpine
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Suprarenin
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Carbachol
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Benzatropine
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What are the symptoms of nerve gas poisoning. Organize symptoms into groups:
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Nicotinic signs: Neuromuscular (twitching, fasciculation, paralysis)
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Central signs: Headache, drowsiness, disorientation, coma or generalized convulsion
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Muscarinic signs: Miosis, nausea, salvitation, vomiting, diarrhea, sweating, bradycardia, bronchial constriction.
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Treatment: Atropine (muscarinic receptor antagonist), diazepam (for convulsion) and pralidoxime or obidoxime (reactivators)
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What are indications for Benzatropine
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Parkinson’s disease
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blurred vision
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fast heartbeats
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vomiting or constipation
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little or no urination
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Side effects of atropine
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Rivastigmine
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Method of Action and indications of
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Reversible inhibitor of acetylcholinesterase (Indirect acting cholinergic agonist)
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Alzheimer’s disease, dementia
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quite well absorbed by oral route and crossing well the blood brain barrier
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Organophosperus poisoning
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Parkinson´s Disease
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symptomatical dehydration
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Tropicamide Indications
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Donepezil
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Rivastigmine
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Gelantamine
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Muscarine Poisoning:
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Increased Salivation, sweating, lacrimation
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Bradycardia, Block, Hypertension
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Generally subsides within 2 Hours
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Dyspnoe, blurrred vision, abdominal pain with nausea and diarrhea
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The specific antigen is Atropine
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Reversible Inhibitor of acetylcholinesterase
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Prioritizes Digestive tract and Bladder over CVS & CNS
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Treatment in myasthenia gravis, posoperative atony (intestine/bladder)
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neostigmine indirectly stimulates both nicotinic and muscarinic receptors
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reversible cholinesterase inhibitor
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Clinical Indications of parasympathic agonists
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Method of Action of Buscopan
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peripheral effects similar to those of atropine
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sedative and tranquillizing action and has an amnestic effect
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treat abdominal cramping and irritable bowel syndrome
=> antispasmodics acting on the smooth musculature
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used as an antiemetic agent in the prevention of motion sickness
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Indication for Atropine
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antidote in muscarinic poisoning
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biliary and renal colic pain
used as antispasmodic for painful smooth muscle spasms
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cardiology: treatment of bradykardia and block.
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anesthesiology : prevention of respiratory tract secretion
● bronchospasm
● laryngospasm
● reflexes
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Atrial Fibrilation
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How does Dopamine act?
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D1 – stimulated at low concentration. Induces renal, mesenteryc and coronary vasodilation. Increase renal blood flow and GFR, Na excretion.
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B1 – Stimulated at higher concentration.
Postitive inotropic effect
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A1 stimulated at high concentrations.Induces vasoconstriction
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Side effects of epinephrine
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fear anxiety, restlessness, tremor
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hypertension & Cardiac arrythmias, can cause anginal pain
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cerebral haemorrhage
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Worse in hyperthyroid and hypersensitive patients.
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Isoprenaline indications
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bradycardia
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atrioventricular block
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Isoprenaline has only cardiovascular indications
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Drugs used to prevent premature labour and receptors
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Salbutamol (short-acting β2 adrenergic receptor agonist)
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Terbutaline (beta‑adrenergic agonist)
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Ritodrine (short-acting β2 adrenoreceptor agonist)
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short-acting β2 adrenergic receptor agonist / β2 Stimulants are used in prevention of premature labour / preterm delivery, they act on the utereine smooth muscle cell β2 receptors causing relaxation
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short-acting β2 & 3 adrenergic receptor antagonist are used in prevention of premature labour / preterm delivery, they act on the utereine smooth muscle cell β3 receptors causing relaxation
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Epinephrine for asthma attacks: Stimulates α1, α2, β1, β2, β3 adrenergic receptors
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Ipratropium / Atrovent; Muscarinic receptor antagonist reduce the effects of acetylcholine
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Salbutamol Inhalator relaxing SMC in the airways by acting on β2 receptors (short acting)
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Treatment of bradycardia
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Side Efffeects of Norepinephrine
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sudden numbness, weakness, or cold feeling anywhere in your body
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hypertension
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reduced blood flow in organs, kidney, liver, brain
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necrosis at site of administration
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problems with vision, speech, or balance; or severe headache, blurred vision, pounding in your neck or ears
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Nasal drops are Alpha 2 agonists with local effects
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Nasal Drops are Alpha 1 effects with peripheral effects but with local administration they give more localized effects
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Nasal Drops (α1 agonists)
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Phenylepinephrine
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Naphazoline
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Tymazoline
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Ksylometazoline
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Indications of Epinephrine
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primarily used in congestive heart failure and shock with low cardiac output
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β1 agonist
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ide effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection
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positive ionotropic action
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Prevention of Asthma Attacks
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Salmeterol,
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formoterol
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bambuterol
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Ipratropium