3953058
Beschreibung
Quiz von Phil Oklam, aktualisiert more than 1 year ago
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Erstellt von Phil Oklam
vor etwa 9 Jahre
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Frage 1
Frage
Where is the TATA box?
Antworten
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-31 to -26
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-32 to -37
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-2 to +4
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+28 to +32
Frage 2
Frage
Where is Inr?
Antworten
-
-2 to +4
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-37 to -32
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-31 to -26
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+28 to +32
Frage 3
Frage
Where is DPE?
Antworten
-
+28 to +32
-
-2 to +4
-
-37 to -32
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-31 to -26
Frage 4
Frage
Where is BRE?
Antworten
-
-37 to -32
-
-31 to -26
-
-2 to +4
-
+28 to +32
Frage 5
Frage
Which are true of CpG Islands?
Antworten
-
rich in CG sequences
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TXN occurs at a lower rate and at several start sites
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C residues escape methylation
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Methylation is associated with silencing of the gene
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Extensively phosphorylated at CTD
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Form a complex on TATA box to recruit RNA Pol II to the promoter
Frage 6
Frage
Which of the following are associated with RNA Pol II?
Antworten
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tRNA
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snRNA
-
mRNA
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miRNA
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rRNA
Frage 7
Frage
Which RNA Polymerase is found in the nucleolus?
Antworten
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RNA Pol I
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RNA Pol II
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RNA Pol III
Frage 8
Frage
Which of the following is the correct sequence for the formation of PIC?
Antworten
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DABPolFEH
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DBAPolFEH
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DABPolEFH
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DAPolEBFH
Frage 9
Frage
Which GTF interacts with RNA Pol II during formation of PIC?
Antworten
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TFIIB
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TFIID
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TFIIA
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TFIIE
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TFIIH
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TFIIF
Frage 10
Frage
What happens to RNA Pol II as it transcribes along RNA?
Antworten
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Phosphorylated at CTD
-
Methylated at CTD
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Acetylated at CTD
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Phosphorylated at N terminal tail
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Acetylatetd at N terminal tail
Frage 11
Frage
Which of the following are true of TFIIH?
Antworten
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It binds over Inr
-
It binds over TATA
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It requires ATP to separate template strand
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It requires NAD to separate template strand
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It is released as RNA Pol II moves
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It stays bound as RNA Pol II moves
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Its CAK subunit contains kinase for phosphorylation
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Its Core subunit contains kinase for phosphorylation
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It contains helicases XPB and XPD
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It contains helicases XPC and XPB
Frage 12
Frage
Which of the following is a trilobular structure containing TBP and TAFs?
Antworten
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TFIID
-
TFIIH
-
TFIIE
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TFIIA
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TFIIB
-
RNA Pol II
Frage 13
Frage
TBP directs assembly of PIC on the TATA complex and only requires TAFs to do so in a TATA-less promoter
Antworten
- True
- False
Frage 14
Frage
Which of the following are UAS common sequence elements?
Antworten
-
GC box
-
Octamer
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CAAT box
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HSE
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SRE
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BRE
-
DPE
Frage 15
Frage
What are leucine zippers, zinc fingers, homeodomains and helix loop helixes all examples of?
Antworten
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DNA binding domains
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Activation domains
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Enhancer elements
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GTFs
Frage 16
Frage
Which of the following are true of Activation domains in activators?
Antworten
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They have a lack of sequence conservation
-
They are generally unstructured
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They contain multiple short segments working together in an additive fashion
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They can be gln rich, proline rich or acidic patches
Frage 17
Frage
How do activators work?
Antworten
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Promote binding of other activators
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Stimulate complex assembly (Recruitment)
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Release stalled RNA Pol II
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Modulation of chromatin
Frage 18
Frage
Which of the following are true of Mediator?
Antworten
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22 polypeptide complex
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Comprised of a head, middle and tail
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Associates with RNA Pol through CTD
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Enhances PIC formation
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Forms a bridge between RNA Pol II and activators
Frage 19
Frage
Which of the following is not a core histone?
Antworten
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H1
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H3
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H4
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H2A
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H2B
Frage 20
Frage
N terminal tails of histones are highly acidic
Antworten
- True
- False
Frage 21
Frage
What do nucleosomes consists of?
Antworten
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2 x H2A-H2B dimers
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H2A-H2B tetramer
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H1 linker histones
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H3-H4 tetramer
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2 x H3-H4 dimers
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147 bp DNA wrapped around the octamer
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471 bp DNA wrapped around the octamer
Frage 22
Frage
Mitotic chromosomes are condensed, interphase chromosomes occupy a distinct territory in the nucleus and are decondensed to about 100-400nm fibres
Antworten
- True
- False
Frage 23
Frage
Which of the following switches off the Gal4 promoter?
Antworten
-
Galactose
-
Glucose
Frage 24
Frage
Which of the following are methods of remodelling chromatin?
Antworten
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Histone variants
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ATP dependent chromatin remodelling
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Post translational modifications
Frage 25
Frage
Which histone does not express variants?
Antworten
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H4
-
H3
-
H1
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H2A
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H2B
Frage 26
Frage
Where do post translational modifications of histones occur?
Antworten
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N-terminal tail
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Histone variants
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C Terminal domain
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DPD
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TBP
Frage 27
Frage
The GNAT and MYST family are which enzymes?
Antworten
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HATs
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HDACs
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HKMTs
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SWI/SNF ATPase
Frage 28
Frage
Histone methylation is readily reversible and has no affect on charge
Antworten
- True
- False
Frage 29
Frage
Specific methylated lysines are recognised by specific proteins, which of the following are markers for repression?
Antworten
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H3 Lys 9
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H3 Lys 27
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H3 Lys 4
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H3 Lys 36
Frage 30
Frage
Which of the following are SWI2/SNF2 ATPase subfamilies?
Antworten
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SWI2/SNF2
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ISWI
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CHD/Mi2
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Ino80
Frage 31
Frage
What is the deletion of SWI/SNF associated with?
Antworten
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Tumours
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Tumour suppression
Frage 32
Frage
Which class of HDACs is not zinc dependent?
Antworten
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Class III
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Class I
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Class II
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Class IV
Frage 33
Frage
Regions of DNA that are hypoacetylated by HDACs are what?
Antworten
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Repressed
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Activated
Frage 34
Frage
Which of the following is an example of an ATP dependent remodeller that commonly mediates repression?
Antworten
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NuRD
-
SWI/SNF
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Ume3
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Rpd3
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Sin3
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HP1
Frage 35
Frage
What is the name of the enzyme that methylates H3K9?
Antworten
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Suvar39
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HP1
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NuRD
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Sin3
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Ume6
Frage 36
Frage
Is Tsix or Xist on the antisense strand of DNA?
Antworten
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Tsix
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Xist
Frage 37
Frage
What is the Role of NF-KB family of transcription factors?
Antworten
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Regulating inflammation, DNA damage, cell death, cell adhesion and proliferation.
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The guardian of the genome.
Frage 38
Frage
NF-KB is pre-synthesised and retained within the cytoplasm in an active form bound to inhibitor protein IxB
Antworten
- True
- False
Frage 39
Frage
Cellular [blank_start]stimulation[blank_end] > IkB phosphorylated > ubiquitination by E3 Ubiquitin ligase > degradation by 26S proteasome > NF-kB free to translocate to the nucleus.
Antworten
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stimulation
-
degradation
Frage 40
Frage
In diseased cells NF-kB control is lost (aberrantly nuclear)
Antworten
- True
- False
Frage 41
Frage
Which of the following do all members of the mammalian NF-KB family contain?
Antworten
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Rel homology domains
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Leucine zipper like domain
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Non conserved transcription activation domains
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PEST domains
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ankyrin repeat motifs
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