450600
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage 1
Frage
What is the main role of a molecular chaperone?
Antworten
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Assist in the folding of other proteins
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Assist in the unfolding of other proteins
-
Assist in the assembly of other proteins
-
Assist in the disassembly of other proteins
Frage 2
Frage
Chaperone proteins are permanent parts of the proteins they fold
Antworten
- True
- False
Frage 3
Frage
Why are chaperone proteins necessary?
Antworten
-
Some proteins have complex folding pathways,
-
Some proteins are inherently soluble
-
Useful for multimeric assembly
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So many proteins folding and interacting mean some need help
Frage 4
Frage
Name the role of the domain highlighted in bacterial trigger factor
Antworten
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PPIase domain
-
Interacts with polypeptide as it comes off the ribosome
-
Binds to L23 of the ribosome
Frage 5
Frage
The highlighted domain of Bacterial trigger factor binds to L23 of the ribosome
Antworten
- True
- False
Frage 6
Frage
The bacterial ribosome and bacterial trigger factor form a complex, so the protein is folded as it comes off the ribosome
Antworten
- True
- False
Frage 7
Frage
The N-domain of the bacterial trigger factor bind to what subunit of what size ribosome?
Antworten
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L23
-
L24
-
L25
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50s
-
40s
-
30s
Frage 8
Frage
After the protein interacts with the T.F, it may interact with what proteins?
Antworten
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DNAK
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DNAJ
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DNAL
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Gro-EL
-
Gro-ER
Frage 9
Frage
What percent of proteins can fold unaided after interacting with DNAK/J?
Antworten
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70%
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65%
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75%
Frage 10
Frage
10-15% of proteins need to use the lidded protein chaperone syastem
Antworten
- True
- False
Frage 11
Frage
15-18% of proteins need further _ interactions?
Antworten
-
DNAK
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DNAJ
-
Gro-El
Frage 12
Frage
Yeast has no trigger factor
Antworten
- True
- False
Frage 13
Frage
In yeast, what protein folding complex interacts with the proteins first?
Antworten
-
Nascent Polypeptide Associated Complex (NAC)
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The Ribosome Associated Complex (RAC)
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CCT
Frage 14
Frage
The RAC complex is made of which proteins?
Antworten
-
Zuptin
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Hsp40
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SSZ
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Hsp70
Frage 15
Frage
SSB is separated from the RAC but also chaperones protein folding
Antworten
- True
- False
Frage 16
Frage
The NAC is made of A and B homologues
Antworten
- True
- False
Frage 17
Frage
What is the role of the NAC?
Antworten
-
Bind to nascent proteins and prevent aggregation
-
Binds to nascent proteins and degrades them based on protein concentrations in the cell
-
Binds to nascent proteins and folds them
Frage 18
Frage
Human cellss don't possess an NAC
Antworten
- True
- False
Frage 19
Frage
Humans have an hRAC rather than an RAC
Antworten
- True
- False
Frage 20
Frage
The human version of the RAC contains which two proteins?
Antworten
-
MPP11
-
SSz
-
Hsp70L1
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SSb
Frage 21
Frage
Name the lidded protein chaperone found in yeast and humans
Antworten
-
Gro-El
-
CCT
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SSb
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Hsp70L1
Frage 22
Antworten
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Hsp40/70- humans
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Hsp40/70- yeast
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SSa/YDJ1- yeast
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Ssa/Ydj1- humans
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Prefoldin
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