454011
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage 1
Frage
Which of the following are caused by hydrolysis?
Antworten
-
Nicks
-
Abasic Sites
-
Cross Links
-
Ds Breaks
Frage 2
Frage
Which of the following are caused by Radical Oxygen Species?
Antworten
-
Bulky alkylation damage
-
Abasic sites
-
ds breas
-
ss breaks
-
Nicks
Frage 3
Frage
What causes Alkylation Damage?
Antworten
-
S-adenosyl methionine
-
Radical oxygen species
-
Interacts with 6th O on guanine
-
Interacts with 3rd O on guanine
Frage 4
Frage
Methylation of guanine results in unstable base pairing
Antworten
- True
- False
Frage 5
Frage
Over two cycles of replication, a methylated C-G will be replaced with an?
Antworten
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A-T
-
C-C
-
G-T
Frage 6
Frage
What protein catalyses Direct Reversal of Guanine methylation?
Antworten
-
Alkyl-Guanine Transferase
-
Adenosyl-Guanine Transferase
-
Adenyl-Guanine Transferase
Frage 7
Frage
The enzyme involved in direct reversal catalyses the transfer of CH3 to the enzyme, killing it
Antworten
- True
- False
Frage 8
Frage
How does the Direct Reversal enzyme 'flip out' the damaged guanine?
Antworten
-
A helix-helix motif
-
A helix-turn-helix motif
-
A sheet-turn-sheet motif
Frage 9
Frage
The enzyme for direct reversal is not specific and so works globally
Antworten
- True
- False
Frage 10
Frage
What is the reading head of the Direct Reversal enzyme made of?
Antworten
-
Ala & Gly
-
Ser & Val
-
Tyr & Ser
Frage 11
Frage
The enzyme binds to the major groove using an HTH motif
Antworten
- True
- False
Frage 12
Frage
Which happens first in the CH3 transfer?
Antworten
-
Lys pushes H onto Tyr
-
Lys pushes CH3 onto Tyr
-
Tyr pushes H onto Lys
Frage 13
Frage
The new H+ pushes e-....
Antworten
-
Onto CH3
-
Onto O bound to CH3
-
Onto Lys bound to CH3
Frage 14
Frage
The e- added to the O pushes the CH3 onto the Lysine
Antworten
- True
- False
Frage 15
Frage
Which of the following recognises the widowed G and fills the gap?
Antworten
-
Arg on the head of the reading head
-
Lys on the head of the reading head
-
Val on the head of the reading head
Frage 16
Frage
UV irradiation of _ causes _?
Antworten
-
Consecutive pyrimidines
-
Consecutive purines
-
Opens a 5-6 bond
-
Opens a 3-4 bond
-
Opens a 4-6 bond
Frage 17
Frage
A phosphobutane photo-dimer is formed
Antworten
- True
- False
Frage 18
Frage
Why is UV radiation dangerous?
Antworten
-
It alters DNA conformation
-
So helicases make mistakes
-
Bases are deleted
-
Bases are duplicated
Frage 19
Frage
How do 6-4 lesions form?
Antworten
-
An O is transfered from on thymine to another
-
An N is transfered from on thymine to another
-
A C is transfered from on thymine to another
Frage 20
Frage
Damage is recognised by bases
Antworten
- True
- False
Frage 21
Frage
How does photolyase work on 6-4 bonds?
Antworten
-
Uses light to reverse the reaction
-
Uses UV to reverse the reaction
-
Binds to DNA and excises damaged bases
Frage 22
Frage
A 'protein wedge' forces DNA apart so it can work
Antworten
- True
- False
Frage 23
Frage
An e- from diazaflavin is removed by UV and is passed onto what?
Antworten
-
FADH
-
NAD
-
NADH
Frage 24
Frage
The electron will hopefully break the distorted bonds
Antworten
- True
- False
Frage 25
Frage
The photolyase process can only work once
Antworten
- True
- False
Frage 26
Frage
Which residues bind to the phosphate backbone in photolyase?
Antworten
-
Glu
-
Arg
-
Gln
Frage 27
Frage
What does the widowed base pair bind to?
Antworten
-
Water
-
Methyl
-
ATP
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