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In normal RBC destruction, globin is recycled and Fe is broken down
Frage 2
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In Intravascular Haemolytic Anaemia, cells are lysed in the blood vessels
Frage 3
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Why is Intravascular H.A so dangerous?
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Hb dimers form in the blood and block the kidneys
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R.B.C fragments block capillaries
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R.B.C's aggregate and block capillaries
Frage 4
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Renal failure and Heamoglobinurea are caused by...
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Intravascular
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Extravascular
Frage 5
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What is implicated in Extravascular Haemolytic Anaemia
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The spleen
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The bone marrow
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The liver
Frage 6
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In Extravascular, macrophage Fc receptors bind to the RBC's Ig's
Frage 7
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Once bound, what happens to RBC's in Haemolytic Anaemia
Frage 8
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If small portions of RBC membrane is removed, what happens?
Frage 9
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Loss of RBC's leads to low glucose in the spleen, which leads to...
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Inc haemolysis
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Fatigue
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Inc risk of diabetes
Frage 10
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Reticuloctosis- inc presence of reticulocytes
Frage 11
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What causes reticulocytosis?
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The body trying to replace lost R.B.C's but can't keep up production
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The damaged R.B.Cs degenerate into reticulocytes
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The lymphocytes attack R.B.Cs, making them degenerate into reticulocytes
Frage 12
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In Drug Induced Haemolytic Anaemia, what happens?
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Drug induced antibodies cross react
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Drug specific antibodies cross react
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Drugs cause R.B.C's to aggregate
Frage 13
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Haemolytic Anaemias can be caused by physical stress....
Frage 14
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March Haemoglobinurea is damge to RBC's in small foot bones due to prolonged marching/running
Frage 15
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Infections can cause H.A by altering R.B.C morphology
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What's the difference between Immune and Autoimmune Haemolytic Anaemia?
Frage 17
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In some cases, an RBC transfusion can lead to degredation of the original RBC's
Frage 18
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Name two types of Inherited Haemolytic Anaemia
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Sickel Cell Anaemia
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Thalassaemia
Frage 19
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Hereditary Spherocytosis is caused by an abnormal membrane causing Spherical R.B.C's