471718
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage 1
Frage
Define leukamia
Antworten
-
Neoplastic proliferation of haemopeoietic or lymphoid cells
-
Neoplastic proliferation of lymphoid cells
-
Neoplastic proliferation of bone marrow
Frage 2
Frage
In acute leukaemia, abnormality occurs in mature cells
Antworten
- True
- False
Frage 3
Frage
Acute leukaemia is described as a block in differentiation
Antworten
- True
- False
Frage 4
Frage
Acute leukaemia is caused by acute proliferation of...
Antworten
-
Myeloblasts
-
Lymphoblasts
-
Both (rare)
-
Both (most common)
Frage 5
Frage
What are the symptoms of chronic leukaemia?
Antworten
-
No block in differentiation
-
Block in differentiation
-
Low proliferation
-
High proliferation
Frage 6
Frage
Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
Antworten
-
Blasts
-
Reticulocytes
-
Lympocytes
Frage 7
Frage
In A.L, there are often reticulocytes in the peripheral blood
Antworten
- True
- False
Frage 8
Frage
Leukaemia is caused by clonal proliferation from a single cell
Antworten
- True
- False
Frage 9
Frage
How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
Antworten
-
Myeloblasts have auer rods
-
Lymphoblasts have auer rods
-
Myeloblasts have a large, pale nucleus
-
Lymphoblasts have a large, pale nucleus
Frage 10
Frage
MUD stands for
Antworten
-
Matched Unrelated Donor
-
Myeloblast Unknown Death
-
Myeloblasts Under Duress
Frage 11
Frage
Remission - no disease in the blood
Antworten
- True
- False
Frage 12
Frage
Why use the Minimal Residual Disease (MUD)?
Antworten
-
Assess chances at relapse/need for further treatment
-
Assess effectiveness of drug
-
Prevent remission
Frage 13
Frage
BMT - Bone Marrow Transplant
Antworten
- True
- False
Frage 14
Frage
B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
Antworten
- True
- False
Frage 15
Frage
Which of the following is has the poorer prognosis
Antworten
-
Acute T-Cell Precursor Lymphoblastic
-
Acute B-Cell Precursor Lymphoblastic
Frage 16
Frage
What is found in cytogenetic testing of ALL?
Antworten
-
Hyperploidy
-
Aneuploidy
-
Nullosomy
Frage 17
Frage
Which of the following are found in ALL cytochemistry?
Antworten
-
MPX/SB are neg
-
MPX/SB are pos
-
PAS block pos
-
PAS block neg
Frage 18
Frage
Which of the following are found in Immunophenotyping for ALL?
Antworten
-
CD19
-
CD7
-
CD10
Frage 19
Frage
What is true of AML?
Antworten
-
Inc WBC
-
Dec RBC
-
Dec Plateles
-
Inc RBC
-
Inc Platelets
Frage 20
Frage
AML means there is no normal cells
Antworten
- True
- False
Frage 21
Frage
What markers are used in Flow Cytometry to identify AML?
Antworten
-
CD13
-
CD33
-
CD12
-
CD4
Frage 22
Frage
AML is more common in adult women
Antworten
- True
- False
Frage 23
Frage
When is AML called 'De Novo'
Antworten
-
When it occurs for the first time
-
If it occurs secondary to other malignancies
-
If it never relapses
Frage 24
Frage
Which of the following is common in AML (as opposed to ALL)
Antworten
-
CNS leukaemia
-
Lymph, spleen and gum problems
-
Lymphodenopathy
Frage 25
Frage
Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC
Antworten
-
A2, B3, C1
-
A1, B2, C3
-
A3 B2 C1
Frage 26
Frage
CML- accumulation of mature myeloid cells
Antworten
- True
- False
Frage 27
Frage
Genetic anomalies in CML occur low down where they effect cells
Antworten
- True
- False
Frage 28
Frage
What happens in 95% of cases to cause AML?
Antworten
-
Chromosome 22 shortens
-
Linking BCR & ABL genes together
-
Chromosome 22 inverts
-
Chromosome 22 lengthens
Frage 29
Frage
In indentifying CML, immunophenotyping is useless
Antworten
- True
- False
Frage 30
Frage
CML is more common in adult men
Antworten
- True
- False
Frage 31
Frage
What is the WBC in CML?
Antworten
-
>50 x 10^9/l
-
<30 x 10^9/l
-
>75 x 10^9/l
Frage 32
Frage
What will be found in a CML bone marrow sample?
Antworten
-
Bone marrow is hypercellular
-
Bone marrow is hypocellular
-
Myeloid cells are present at all developmental stages
-
Inc Neutraphil Alkaline Phosphatase
-
Red Neutraphil Alkaline Phosphatase
Frage 33
Frage
Glivec stops CML cells dividing, but is expensive
Antworten
- True
- False
Frage 34
Frage
CLL- Neoplastic proliferation of mature looking lymphocytes
Antworten
- True
- False
Frage 35
Frage
What ususally happens in CML?
Antworten
-
Lymphoids form masses in the bone marrow, spleen and lymph nodes
-
Lymphoids lyse and release contents as they are made poorly
-
Lymphs begin attacking body cells
Frage 36
Frage
In CLL, the lymph population can be over 300x the normal
Antworten
- True
- False
Frage 37
Frage
What are smear cells?
Antworten
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Cells that rupture during a smear
-
Cells so malleable they look like smudges
-
Cells so deformed they form masses, which look like smears
Frage 38
Frage
In CLL, the bone marrow is <25% lymphocytes
Antworten
- True
- False
Frage 39
Frage
What does immunophenotyping in CLL tell us?
Antworten
-
Clonality
-
Which lymph cells they are
-
The markers
Frage 40
Frage
CLL is more common in old men
Antworten
- True
- False
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