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Ag- Any substance that may be recognised as foreign
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What is this, and what is it for?
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Ig G
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Ig M
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Crossing the placenta
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What is Ig M use for?
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Crossing the placenta
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Rapid agglutination
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Bound to B cells
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The Rhesus positive allele is...
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Dominant
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Recessive
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Co-dominant
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Homozygous dd has the potential to produce Anti-D in what circumstances
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Illness
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Incorrect transfusion
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Pregnancy
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Sensitisation- binding of Ig to individual blood cell
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Agglutination is visible when
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The Ig binds
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A lattice is formed
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The blood cells lyse
Frage 8
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Which of the following RBC's contain the H substance (L-Fucose)
Frage 9
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Type AB has what added to the H substance?
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N-Galactosamine
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D- Galactose
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N-Glucosamine
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Acetyl CoA
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Which of the following is the 'Universal Receiver'?
Frage 11
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How do blood grouping cards work?
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Tiny columns of small beads with Ig's bound
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If blood agglutinates due to Ig's, it cannot pass through column
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If blood agglutinates due to Ig's, it sinks to the bottom of the column
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1 in 40 people have Ig's other than ABO and Rhesus
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How many Ig's (other than ABO and Rhesus) can cause haemolytic reactions
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3 Cells are brought in as controls- why?
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Between the three of them, they cover all 20 Ig's
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Then the patient plasma is added, and the reaction studied
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If the plasma reacts to any of the 20 Ig's, what happens?
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They're tested against 10 donors (process of elimination)
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They're tested against 20 donors (process of elimination)
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They're tested against 15 donors (process of elimination)
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Pregnant women protect their fetuses by injecting Anti-D
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What is cross matching?
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Transfusions are necessary if >40% of blood is lost
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What is an Exchange Transfusion?
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Exchange transfusion is used for babies with HDN
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Why are antibodies the issue in blood transfusions?
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They are much more abundant than RBC's
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RBC's don't contain the MAC Class 1 marker that allows self cells to be identified
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RBC reactions can be easily stopped
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RBC's are stored in 120-200 ml quantities
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1 unit of RBC's is expected to raise blood Hb by how much?
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Blood is transfused over 2-3 hours
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1 bag of RBC's costs how much?
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Plasma has a shelf life of _ and a half life of _ once unfrozen
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2 years
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1 year
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6 months
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4-8 hours
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2-4 hours
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With plasma, Universal Donor's and Receivers are reversed
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Plasma is dosed at 12-15ml/kg
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Plasma also contains
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Clotting factors
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Ig's
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Drugs
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A bag of plasma and clotting factors costs £40.00
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Cryoprecipitate contains concentrated clotting factors and Ig's
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Cryoprecipitate has a shelf life of _ at -30 degrees
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When is cryoprecipitate added?
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Platlets are stored at 22 degrees and cannot be refrigerated
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Platelets have a shelf life of 7 days if...
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it's kept agitated
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it's kept frozen
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it is stored in a vacuum
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Platelets are given over 30 mins and increase blood count by 3-4 x 10^9
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Platelets cost £20 a bag