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Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage 1
Frage
The Extrinsic Pathway operates on the initiating cell
Antworten
- True
- False
Frage 2
Frage
What is the role of the Extrinsic Pathway?
Antworten
-
Coagulation initiation
-
Formation of the fibrin plug
-
Activation of Factor V
Frage 3
Frage
The Intrinsic Pathway works on...
Antworten
-
The endothelium
-
The vW factor
-
The platelet surface
Frage 4
Frage
The Intrinsic pathway is designed to generate thrombin bursts
Antworten
- True
- False
Frage 5
Frage
Name the three steps of Coagulation
Antworten
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Initiation
-
Amplification
-
Propagation
Frage 6
Frage
What begins the Initiation phase?
Antworten
-
Vascular injury initiates trigger factor
-
Vascular injury exposes collagen for platelets to bind
-
Vascular injury causes blood cells to lyse
Frage 7
Frage
Trigger factor activates VII, which activates smal amounts of
Antworten
-
IX
-
X
-
XI
Frage 8
Frage
X & XI bind to platelets and produce small amounts of Thrombulin
Antworten
- True
- False
Frage 9
Frage
Thrombin initiates Amplification
Antworten
- True
- False
Frage 10
Frage
The platelets act as a surface for the assembly of what factor complexes?
Antworten
-
IX & VIII
-
Prethrombinase (X & V)
Frage 11
Frage
What happens in Propogation
Antworten
-
Activated platelets/complexes generate Thrombin Burst
-
Activated platelets/complexes generate Thrombulin Burst
-
Activated platelets/complexes generate Thromblin Burst
Frage 12
Frage
What two things are required for Fibrin Clot formation?
Antworten
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Fibrinogen --> Fibrin
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F IIa
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F III
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F V
Frage 13
Frage
Thrombin production is the crucial step in haemostasis
Antworten
- True
- False
Frage 14
Frage
The first step in Coagulation Disorder diagnosis is a family & drug history
Antworten
- True
- False
Frage 15
Frage
Name the two main clinical presentation of coagulation disorders
Antworten
-
Bleeding in deep tissues
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Bleeding in joints
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Flushed skin
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Easy cutting of skin
Frage 16
Frage
Prethrombin Time is anassessment of the _ Pathway
Antworten
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Extrinsic
-
Instrinsic
Frage 17
Frage
Prethrombin time is expressed as an international, normalised ratio
Antworten
- True
- False
Frage 18
Frage
Activated Partial Thromboplastin Time is an indicator of...
Antworten
-
Intrinsic pathway
-
Extrinsic pathway
Frage 19
Frage
Which of the following are not Coagulation Disorder investigations?
Antworten
-
Fibrinogen Assay
-
FXIII Screen
-
Thrombin Clotting Time
-
Fibin Clotting Time
Frage 20
Frage
How do you evaluate increased prethrombin time?
Antworten
-
Mix with normal platelets (50:50)
-
Remove half the platelets from a sample
-
Then a Factor VII assay
Frage 21
Frage
How do you evaluate Activated Partial Thromboplastin Time (APPT)?
Antworten
-
Mix with normal plasma
-
Then do a Factor VIII, IX, XI assay
-
Then a FXII assay
Frage 22
Frage
Lack o Factor X causes no symptoms
Antworten
- True
- False
Frage 23
Frage
Factor I assay is used if bot PT and APTT is elevated
Antworten
- True
- False
Frage 24
Frage
If both PT and APTT is normal, what is tested for?
Antworten
-
Factor XIII
-
TCT
-
Factor X
Frage 25
Frage
Aquired Coagulation Deficiencies are caused by a lack of what?
Antworten
-
Vit A
-
Vit B
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Vic D
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Vit K
Frage 26
Frage
What can cause Aquired Vit K deficiency?
Antworten
-
DIC
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Massive Transfusion Effect
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Malabsorption
Frage 27
Frage
Vit-K deficiency can be drug induced i.e. in the case of liver disease
Antworten
- True
- False
Frage 28
Frage
Haemophilia A is caused by what?
Antworten
-
Factor VIII deficiency
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Factor VI deficiency
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Factor V deficiency
Frage 29
Frage
Haemophilia A is sex linked
Antworten
- True
- False
Frage 30
Frage
Haemophilia B is a Factor IX deficiency
Antworten
- True
- False
Frage 31
Frage
The mutations for Haemophilia A & B are found on which chromosome?
Antworten
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X
-
Y
Frage 32
Frage
How do you identify Haemophilia B?
Antworten
-
Inc PT
-
Inc APTT
-
Factor IX assay
Frage 33
Frage
Von Willebrands disease is caused by a lack of factor
Antworten
-
VIII
-
VII
-
VI
Frage 34
Frage
vW disease is detected by
Antworten
-
FVIII Assay
-
vWF assay
Frage 35
Frage
Since many things can effect the levels of vWF, testing is difficult
Antworten
- True
- False
Frage 36
Frage
vW disease can be qualitative or quantitative
Antworten
- True
- False
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