Immunology Review Questions

1. Which leukocyte is most prevalent in the innate immune response? [blank_start]Neutrophils[blank_end] 2. What cellular component of innate immunity will kill a cell lacking MHCI? [blank_start]NK Cell[blank_end] 3. What type of cells have TLRs? [blank_start]APC's[blank_end] 4. Which cytokines can cause fever? (hint: the same 3 are the MOST important pro-inflammatory cytokines) [blank_start]IL-1, TNF-alpha, IL-6[blank_end] 5. What is the hallmark of acute inflammation? [blank_start]PMN's[blank_end] 6.what is the hallmark of chronic inflammation? [blank_start]Macrophages[blank_end] 7. Where is the largest reserve of neutrophils? [blank_start]In the bone marrow[blank_end]

1. Is complement involved in innate or adaptive immunity? [blank_start]Both[blank_end] 2. Where are C3 and C5 produced? [blank_start]In the liver[blank_end] 3. What are the 3 ways that C3 can be activated? [blank_start]Alternate pathway[blank_end], [blank_start]Classical Pathway[blank_end], [blank_start]Lectin Pathway[blank_end] 4. Which complement component is involved in phagocytosis? [blank_start]C3b[blank_end] 5. In a complement fixation assay, if antigen specific antibodies are present what will the test result be? [blank_start]Positive (no hemolysis)[blank_end] 6. In general, what are the two main responses of the innate immune system once a pathogen gets past anatomical barriers? [blank_start]Complement and/or inflammation[blank_end] 7. What are the precursors to tissue macrophages? [blank_start]Monocytes[blank_end]

1. After a one month bacterial infection, what is the predominant antibody response? [blank_start]IgG[blank_end] 2. During costimulation between an APC and Th cell, what component of the APC binds to CD28? [blank_start]B7[blank_end] 3. What type of immune response do Th1 cells stimulate? [blank_start]CMI[blank_end] 4. What major cytokines are released during the Th1 response? [blank_start]IFN gamma and IL2[blank_end] 5. What type of immune response do Th2 cells stimulate? [blank_start]Humoral[blank_end] 6. What major cytokines are released during the Th2 response? [blank_start]IL4[blank_end] 7. Which MHC class does the CD4 TCR bind to? [blank_start]MHC class II[blank_end] 8. On what type of cells is MHCI located? [blank_start]All nucleated "self" cells[blank_end]

1. CD20 is on the surface of what cell type? [blank_start]B cells[blank_end] 2. What are rag1 and rag 2 enzymes involved in? Generation of the [blank_start]TCR (and BCR)[blank_end] 3. What type of antigens are presented on MHC class II? [blank_start]Extracellular[blank_end] 4. MHC class I interacted with the TCR of which T cell type? [blank_start]CD8 T cells[blank_end] 5. What cells express MHC class II? The "professional" APC's --> [blank_start]dendritic cells, macrophages, B cells[blank_end] 6. Which antibody is a pentamer? [blank_start]IgM[blank_end] 7. Which antibody is found in mucous secretions, tears and saliva? [blank_start]IgA[blank_end] 8. What type of immune response is involved in RA? [blank_start]Both the B cell and T cell responses[blank_end]

1. Where do T cells mature? [blank_start]In the thymus[blank_end] 2. Which complement component is on the surface of microbial cells? [blank_start]C3b[blank_end] 3. What initiates the lectin binding pathway in complement? [blank_start]Mannose[blank_end] 4. What antibody is produced in the GALT? [blank_start]IgA[blank_end] 5. What antibody is involved in the allergic response? [blank_start]IgE[blank_end] 6. What component of the T cell is destroyed by HIV? [blank_start]CD4[blank_end] 7. A person with anti-A serum is what blood type? [blank_start]B[blank_end]

1. Molecular mimicry from which organism causes myocarditis in acute rheumatic fever? [blank_start]Strep pyogenes[blank_end] 2. What type of hypersensitivity reaction is that (referring to question 1)? [blank_start]Type II[blank_end] 3. Soluble immune complexes are involved in which hypersensitivity? [blank_start]Type III[blank_end] 4. What type of hypersensitivity reaction is acute transplant rejection? [blank_start]Type IV[blank_end] 5. Give examples of type III hypersensitivities. [blank_start]SLE and strep[blank_end] (immune complexes deposit in kidneys and cause glomerulonephritis), [blank_start]RA[blank_end] (immune complexes deposit into joints) 6. What is the characteristic appearance of SLE? [blank_start]Malar/butterfly[blank_end] rash ([blank_start]wolf like appearance[blank_end]) 7. Type IV hypersensitivity reactions involve what cell type? [blank_start]T cells[blank_end] (no antibodies are involved) 8. What do mast cells release during the early phase response in type I hypersensitivity? [blank_start]Histamine[blank_end]

1. Antibodies against epidermal cadherin resulting in blistering of the skin is characteristic of what? [blank_start]Pemphigus[blank_end] [blank_start](Type II[blank_end] hypersensitivity) 2. What type of cells destroy tumor cells? [blank_start]NK Cells[blank_end] 3. Give an example of an [blank_start]allograft[blank_end]. Transplant btw individuals that are not identical twins 4. Which immune responses are involved in chronic transplant rejection? [blank_start]Antibodies and T Cell mediated[blank_end] 5. What is the most effective type of vaccine and why? [blank_start]Live attenuated[blank_end] because it is able to induce [blank_start]CMI[blank_end] 6. What is are routes of administration for vaccines? [blank_start]IM[blank_end], [blank_start]Intranasal[blank_end], [blank_start]Oral[blank_end]

1. What are anti-inflammatory agents that suppress the immune system? [blank_start]Glucocorticoids[blank_end] 2. What type of cancer cell is used in the construction of mabs? [blank_start]Multiple myeloma cells[blank_end] 3. Give an example of an anti-TNF alpha mab. [blank_start]Infliximab or adalimumab[blank_end] 4. Ipilimumab is a mab against which antigen that is a negative T cell regulator? [blank_start]CTLA-4[blank_end]