5232031
Beschreibung
Quiz von sbpharmacy, aktualisiert more than 1 year ago
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Erstellt von sbpharmacy
vor mehr als 8 Jahre
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Frage 1
Frage
What is the scientific name for cancer?
[blank_start]Oncology[blank_end]
Antworten
-
Oncology
Frage 2
Frage
What is the word used for a cancerous growth?
[blank_start]Malignant[blank_end]
Antworten
-
Malignant
Frage 3
Frage
Carcinomas derive from [blank_start]epithelial cells[blank_end]
Antworten
-
epithelial cells
Frage 4
Frage
What type of tumour derives from connective tissue?
[blank_start]Sarcomas[blank_end]
Antworten
-
Sarcomas
Frage 5
Frage
What type of tumour derives from thin layers of tissue surrounding internal organs?
[blank_start]Mesotheliomas[blank_end]
Antworten
-
Mesotheliomas
Frage 6
Frage
What type of tumour derives from glial cells in the brain?
[blank_start]Gliomas[blank_end]
Antworten
-
Gliomas
Frage 7
Frage
[blank_start]Germinomas[blank_end] derive from germ cells (which are non-[blank_start]differentiated[blank_end] cells)
Antworten
-
Germinomas
-
differentiated
Frage 8
Frage
What does leukemia derive from?
[blank_start]Bone marrow[blank_end]
Antworten
-
Bone marrow
Frage 9
Frage
The proportion of tumour cells dividing and cycling is known as the [blank_start]growth[blank_end] [blank_start]fraction[blank_end]
Antworten
-
growth
-
fraction
Frage 10
Frage
Name three folic acid antagonists.
1 - [blank_start]methotrexate[blank_end]
2 - [blank_start]pemetrexed[blank_end]
3 - [blank_start]raltitrexed[blank_end]
Antworten
-
methotrexate
-
pemetrexed
-
raltitrexed
Frage 11
Frage
Name four pyrimidine analogues.
1 - [blank_start]fluorouracil[blank_end]
2 - [blank_start]cytarabine[blank_end]
3 - [blank_start]capecitabine[blank_end]
4 - [blank_start]gemcitabine[blank_end]
Antworten
-
fluorouracil
-
cytarabine
-
capecitabine
-
gemcitabine
Frage 12
Frage
Name five purine analogues.
1 - [blank_start]mercaptopurine[blank_end]
2 - [blank_start]thioguanine[blank_end]
3 - [blank_start]cladribine[blank_end]
4 - [blank_start]clorabine[blank_end]
5 - [blank_start]fludarabine[blank_end]
Antworten
-
mercaptopurine
-
thioguanine
-
cladribine
-
clorabine
-
fludarabine
Frage 13
Frage
Methotrexate works by attacking/inhibiting [blank_start]dihydrofolate[blank_end] reductase. This prevents [blank_start]dihydrofolate[blank_end] being converted into [blank_start]tetrahydrofolate[blank_end].
Antworten
-
dihydrofolate
-
dihydrofolate
-
tetrahydrofolate
Frage 14
Frage
Fluorouracil mimics which nitrogenous base?
Antworten
-
cytosine
-
guanine
-
thiamine
-
adenine
Frage 15
Frage
Name two main nitrogen mustard based alkylating agents.
1 - [blank_start]chlorambucil[blank_end]
2 - [blank_start]cyclophosphamide[blank_end]
Antworten
-
chlorambucil
-
cyclophosphamide
Frage 16
Frage
Alkylating agents, such as [blank_start]cyclophosphamide[blank_end], work by [blank_start]crosslinking[blank_end] between [blank_start]guanine[blank_end] nitrogenous bases. This produces a [blank_start]stable[blank_end] structure which is hard to break meaning DNA is not longer able to [blank_start]replicate[blank_end].
Antworten
-
cyclophosphamide
-
crosslinking
-
guanine
-
stable
-
replicate
Frage 17
Frage
Cisplatin and carboplatin are examples of which anticancer type drugs?
[blank_start]platinating agents[blank_end]
Antworten
-
platinating agents
Frage 18
Frage
Name two platinating agents.
1 - [blank_start]cisplatin[blank_end]
2 - [blank_start]carboplatin[blank_end]
Antworten
-
cisplatin
-
carboplatin
Frage 19
Frage
Which main element do platinating agents contain?
[blank_start]platinum[blank_end]
Antworten
-
platinum
Frage 20
Frage
In [blank_start]aqueous[blank_end] conditions, the [blank_start]chlorine[blank_end] group of platinating agents is replaced with [blank_start]water[blank_end]. The nitrogen on the [blank_start]guanine[blank_end] base can displace water and binds tightly to the drug.
Antworten
-
aqueous
-
chlorine
-
water
-
guanine
Frage 21
Frage
The bond formed by platinating agents and DNA bases is stronger than the covalent bonds formed between alkylating agents and DNA bases.
Antworten
- True
- False
Frage 22
Frage
Antitumor antibiotics and derived from [blank_start]Streptomyces[blank_end] species.
Antworten
-
Streptomyces
Frage 23
Frage
Name six main groups/drugs of antibiotics used in cancer chemotherapy (in alphabetical order).
1 - [blank_start]anthracyclines[blank_end]
2 - [blank_start]bleomycin[blank_end]
3 - [blank_start]dactinomycin[blank_end]
4 - [blank_start]hydroxycarbamide[blank_end]
5 - [blank_start]mitomycin C[blank_end]
6 - [blank_start]procarbazine[blank_end]
Antworten
-
anthracyclines
-
bleomycin
-
dactinomycin
-
hydroxycarbamide
-
mitomycin C
-
procarbazine
Frage 24
Frage
The main anticancer anthracycline antibiotic is [blank_start]doxorubicin[blank_end].
Antworten
-
doxorubicin
Frage 25
Frage
Anthracyclines are used mainly in lung, breast cancer, and leukaemia.
Antworten
- True
- False
Frage 26
Frage
Which enzyme does doxorubicin inhibit?
[blank_start]topoisomerase II[blank_end]
Antworten
-
topoisomerase II
Frage 27
Frage
What is the main adverse effect of anthracyclines?
[blank_start]Cardiotoxicity[blank_end]
Antworten
-
Cardiotoxicity
Frage 28
Frage
Dactinomycin is used mainly for breast, stomach, lung, pancreas, bladder, and anal cancers.
Antworten
- True
- False
Frage 29
Frage
Dactinomycin works mainly by [blank_start]intercalating[blank_end] with DNA at the [blank_start]transcription initiation[blank_end] complex, which prevents [blank_start]RNA polymerase[blank_end] action.
Antworten
-
intercalating
-
transcription initiation
-
RNA polymerase
Frage 30
Frage
Bleomycin is used mainly for treatment of Hodgkin's lymphoma, and non-Hodgkin's lymphoma.
Antworten
- True
- False
Frage 31
Frage
Bleomycin works by [blank_start]chelating[blank_end] with [blank_start]metal[blank_end] ions (mainly [blank_start]iron[blank_end]), which produces [blank_start]free-radicals[blank_end] that [blank_start]cleave[blank_end] DNA. Oxygen is required for this to occur.
Antworten
-
chelating
-
metal
-
iron
-
free-radicals
-
cleave
Frage 32
Frage
Dactinomycin causes pulmonary fibrosis and dermatological toxicity.
Antworten
- True
- False
Frage 33
Frage
Mitomycin C is a [blank_start]pro-drug[blank_end]. It is enzymatically activated to produce an [blank_start]alkylating[blank_end] metabolite.
Antworten
-
pro-drug
-
alkylating
Frage 34
Frage
Procarbazine is used mainly in the treatment of Hodgkin's lymphoma.
Antworten
- True
- False
Frage 35
Frage
Procarbazine is a [blank_start]pro-drug[blank_end] which breaks down to [blank_start]azo-carbazine[blank_end] in the body. This reaction produces [blank_start]hydrogen peroxide[blank_end] which causes damage to [blank_start]DNA[blank_end]. It interferes with DNA and RNA [blank_start]synthesis[blank_end].
Antworten
-
pro-drug
-
azo-carbazine
-
hydrogen peroxide
-
DNA
-
synthesis
Frage 36
Frage
Hydroxycarbamide interacts with many drugs because it inhibits monoamine oxidase.
Antworten
- True
- False
Frage 37
Frage
[blank_start]Hydroxycarbamide[blank_end] is used for the treatment of chronic myelogenous leukaemia.
Antworten
-
Hydroxycarbamide
Frage 38
Frage
Hydroxycarbamide works by inhibiting [blank_start]ribonucleotide reductase[blank_end]. This enzyme is responsible for catalysing DNA from RNA strands.
Antworten
-
ribonucleotide reductase
Frage 39
Frage
What is the main side effect of hydroxycarbamide?
[blank_start]Myelosuppression[blank_end]
Antworten
-
Myelosuppression
Frage 40
Frage
ABVD is the name of one the chemotherapy treatments used to treat [blank_start]Hodgkin's lymphoma[blank_end]. It is made up of the drugs
A = [blank_start]Adriamycin[blank_end]
B = [blank_start]Bleomycin[blank_end]
C = [blank_start]Vinblastine[blank_end]
D = [blank_start]Dacarbazine[blank_end]
Antworten
-
Hodgkin's lymphoma
-
testicular cancer
-
non-Hodgkin's lymphoma
-
breast cancer
-
bladder cancer
-
brain tumours
-
Adriamycin
-
Amsacrine
-
Alemtuzumab
-
Aromasin
-
Aclarubicin
-
Bleomycin
-
Busulfan
-
Buserelin
-
Bevacizumab
-
Vinblastine
-
Vectibix
-
Viadur
-
Vincristine
-
Vindesine
-
Vinorelbine
-
Dacarbazine
-
Doxorubicin
-
Daunorubicin
-
Dactinomycin
Frage 41
Frage
Name four plant derived cancer therapy agents.
1. C[blank_start]amptothecins[blank_end]
2. E[blank_start]toposide[blank_end]
3. T[blank_start]axanes[blank_end]
4. V[blank_start]inca[blank_end] a[blank_start]lkaloids[blank_end]
Antworten
-
amptothecins
-
toposide
-
axanes
-
inca
-
lkaloids
Frage 42
Frage
Vinca alkaloids are derived from Madagascar Periwinkle.
Antworten
- True
- False
Frage 43
Frage
Vinca alkaloids work by binding to [blank_start]tubulin[blank_end]. This prevents [blank_start]spindle[blank_end] formation in mitosis. The disruption of [blank_start]microtubules[blank_end] stops mitosis in [blank_start]metaphase[blank_end]. Vinca alkaloids affect all [blank_start]rapidly[blank_end] dividing cell types.
Antworten
-
tubulin
-
spindle
-
microtubules
-
metaphase
-
rapidly
Frage 44
Frage
Vincristine is used in the treatment of non-Hodgkin's lymphoma and Hodgkin's lymphoma.
Antworten
- True
- False
Frage 45
Frage
The brand name for vincristine is [blank_start]Oncovin[blank_end]
Antworten
-
Oncovin
Frage 46
Frage
Name two taxane drugs.
1. [blank_start]Paclitaxel[blank_end]
2. [blank_start]Docetaxel[blank_end]
Antworten
-
Paclitaxel
-
Docetaxel
Frage 47
Frage
Taxanes work by stabilising [blank_start]microtubules[blank_end] preventing [blank_start]mitosis[blank_end].
Antworten
-
microtubules
-
mitosis
Frage 48
Frage
Camptothecins inhibits topoisomerase I
Antworten
- True
- False
Frage 49
Frage
Etoposide inhibits topoisomerase I
Antworten
- True
- False
Frage 50
Frage
Name two camptothecins.
1. t[blank_start]opotecan[blank_end]
2. i[blank_start]rinotecan[blank_end]
Antworten
-
opotecan
-
rinotecan
Frage 51
Frage
Name six anthracyclines (other than doxorubicin)
1 - a[blank_start]driamycin[blank_end]
2 - a[blank_start]clarubicin[blank_end]
3 - d[blank_start]aunorubicin[blank_end]
4 - e[blank_start]pirubicin[blank_end]
5 - i[blank_start]darubicin[blank_end]
6 - m[blank_start]itozantrone[blank_end]
Antworten
-
driamycin
-
clarubicin
-
aunorubicin
-
pirubicin
-
darubicin
-
itozantrone
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