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Quiz von Jim Shimoda, aktualisiert more than 1 year ago
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Erstellt von Jim Shimoda
vor fast 8 Jahre
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Frage 1
Frage
Congenital adrenal hyperplasia can be caused by...
Antworten
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A lack of 21-Beta-Hydroxylase
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A lack of 11-alpha-hydroxylase
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A lack of both
-
A lack of either
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None of the above
Frage 2
Frage
A lack of oxytocin can be caused by
Antworten
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A problem with the anterior pituitary gland
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A problem with the supraoptic nucleus of the hypothalamus
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An excess of vasopressin
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Grave's disease
Frage 3
Frage
Oxytocin and vasopressin are protected from degradation by
Antworten
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Antigens
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Their large size
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Amidation
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Disulfide bridges
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Both amidation and disulfide bridges
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Amidation and antigens
Frage 4
Frage
A patient presents with moon facies, abdominal striations, a hump behind the neck, and abdominal adipose tissue build up, tests demonstrate high cortisol and high ACTH levels. This patient most likely has:
Antworten
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Addison's disease
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Cushing's Syndrome caused by adrenal malfunction
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Cushing's Syndrome caused by Cushing's disease
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Wollf-Chaikov disease
Frage 5
Frage
Which of these is the strongest inhibitor of ACTH production?
Antworten
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High cortisol levels
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Sleep-wake transition
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High Growth Hormone levels
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Hyperthyroidism
Frage 6
Frage
A lack of Tyrosine in the thyroid would cause
Antworten
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The overproduction of T4
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The underproduction of T3
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The overproduction of TBG
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The underproduction of both T3 and T4
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The underproduction of both TBG and TSH
Frage 7
Frage
Competitive inhibition of the follicular iodide pump due to excess _____________ can halt the production of ___________
Antworten
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perchlorate ; thyroid hormones
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thyroid hormones ; TSH
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TSH ; thyroid hormones
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Oxytocin ; Vasopressin
Frage 8
Frage
(Choose the most accurate answer) - Synthesis of Thyroid hormones (T3 and T4) occurs....
Antworten
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In the pituitary gland
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In the thyroid
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In the follicular space
-
In the follicular cells
Frage 9
Frage
A patient in the first trimester of pregnancy presents with hyperthyroidism, high Thyroid hormone levels, and low TSH levels. The recommended course of treatment is
Antworten
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PTU
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Methimazole
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Exogenous TSH
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Radioactive Iodine
Frage 10
Frage
Prenatal iodine deficiency causes
Antworten
-
Cretinism
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Overproduction of Growth Hormone
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Grave's disease
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Hashimoto's Thyroiditis
Frage 11
Frage
________ has a longer half-life in plasma
Antworten
-
T4
-
T3
Frage 12
Frage
Conversion of T4 to T3 occurs in the:
Antworten
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Thyroid
-
Pituitary gland
-
Peripheral tissues
-
TBG
Frage 13
Frage
Choose the correct relationship between somatostatin and the hormone(s) below:
Antworten
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Somatostatin inhibits TSH, Promotes GH
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Somatostatin inhibits both TSH and GH
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Somatostatin inhibits GH, has no effect on TSH
-
Somatostatin promotes TSH and inhibits GH
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Somatostatin has no effect on TSH or GH
Frage 14
Frage
Thyroid hormone receptors are:
Antworten
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Bound to DNA and activated when T3 binds to the receptor
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In the nucleus, are activated and bind to DNA when T3 binds the receptor
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On the membrane of cells, act via second messengers
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Deactivated by HSP90 binding, which is only removed when T3 binds the receptor
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Only activated by T4, not T3
Frage 15
Frage
Hashimoto's thyroiditis is causes
Antworten
-
Hyperthyroidism
-
Hypothyroidism
Frage 16
Frage
Cerebral osmoreceptors in the __________ respond to changes in the blood osmolality
Antworten
-
Supraoptic nucleus
-
OVLT and SFO
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Posterior pituitary
-
Anterior pituitary
Frage 17
Frage
Plasma concentration of AVP is a function of....
Antworten
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ADH concentration
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Osmotic threshold
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Oxytocin concentration
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Urine osmolality and Osmotic Threshold
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Plasma osmolality and Osmotic Threshold
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Plasma Osmolality, osmotic threshold, and BP
Frage 18
Frage
Maximum antidiuresis occurs at what concentration of AVP?
Antworten
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5 pg/ml
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20 pg/ml
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5 mg/ml
Frage 19
Frage
At constant plasma osmolality, a decrease in blood pressure leads to
Antworten
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An increase of AVP concentration
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An increase of oxytocin concentration
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A decrease of AVP concentration
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Both A and B
Frage 20
Frage
AVP functions by
Antworten
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Increasing the number of Aquaporins in the kidney tubule lumen
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increasing Protein Kinase A activity in kidney tubule cells
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Exocytosis of AQP2 containing vesicles in kidney tubule cells
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All of the above
Frage 21
Frage
Nephrogenic diabetes insipidus is caused by:
Antworten
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Lack of AVP production in the posterior pituitary
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Problems with V1a receptors in the CNS
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Problems with V2 receptors in the kidneys
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Problems with oxytocin receptors
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Placental secretion of vasopressinase
Frage 22
Frage
If excess Potassium is detected, ____________ secretion will occur
Antworten
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Aldosterone
-
Cortisol
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Growth Hormone
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Vasopressin
Frage 23
Frage
Steroid receptors work by
Antworten
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Binding HSP90 and beginning transcription
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Binding G-proteins that have been released by membrane receptors
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Releasing HSP90 upon binding a steroid
Frage 24
Frage
What is the major dimerization partner for receptors?
Antworten
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RAR
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RXR
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PPAR
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GR
Frage 25
Frage
In a Stachard plot, a hormone that binds two different receptors with different affinities makes a _________ line.
Antworten
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Straight
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Curved
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It actually makes two lines
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Vetical
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Horizontal
Frage 26
Frage
On a hormone binding curve, a left-shift equals a(n) ___________
Antworten
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Increase in affinity
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Decrease in affinity
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increase in plasma hormone concentration
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Decrease in plasma hormone concentration
Frage 27
Frage
In the islet of Langerhans
Antworten
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Beta cells produce glucagon
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Gamma cells produce insulin
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Blood flows from the periphery to the center
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Beta cells are the most numerous
Frage 28
Frage
In the pancreas, endocrine glands secret ___________ and exocrine glands secrete ___________
Antworten
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directly into an artery ; directly into a vein
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into a vein ; into the digestive system
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into the pancreatic duct ; into the venous system
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into the digestive system ; into the liver
Frage 29
Frage
The cell type(s) of the islet of langerhans that serete Ghrelin are:
Antworten
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Epsilon and alpha
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Beta and alpha
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F cells
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Beta only
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epsilon only
Frage 30
Frage
Pancreatic F cells release:
Antworten
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Insulin
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Glucagon
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Somatostatin
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Pancreatic polypeptide
Frage 31
Frage
Put these steps into the proper order for Insulin excretion
1) Rise in ATP
2) Opening of inflowing calcium channels
3) Entry of Glucose through the GLUT2 channel
4)Opening of Voltage gated K channel
5) Insulin secretion
Antworten
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1, 5, 3, 4, 2
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3, 1, 5, 2, 4
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4, 3, 1, 2, 5
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3, 1, 4, 2, 5
Frage 32
Frage
Insulin exocytosis from Beta cells is most similar to which process:
Antworten
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TBG exocytosis from the thyroid follicle cells
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Exocrine gland function of pancreas cells
-
Acetylcholine exocytosis in the Neuromuscular junction
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Posterior pituitary hormone release
Frage 33
Frage
In the presence of high norepinephrine levels, the exocytosis of insulin from Beta cells is
Antworten
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Increased
-
Inhibited
-
Unaffected
-
Only affected if epinephrine is also present
Frage 34
Frage
How does amylin assist in glycemic regulation
Antworten
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It doesn't
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Slows gastric emptying
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Boosts insulin levels
-
Forms plaques that speed glucose uptake
Frage 35
Frage
How does caffeine effect Beta cell exhaustion
Antworten
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Dude, caffeine is bad for you. Everyone knows that.
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Breaks up amyloid plaques, keeping Beta cells functional longer
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Slows insulin release, regulating Beta cell function
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Stimulates insulin release, helping relieve type 2 diabetes
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Stimulates insulin release, helping relieve type 1 diabetes
Frage 36
Frage
Over-release of growth hormone in childhood causes:
Antworten
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Gigantism
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Acromegaly
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TSH release
-
Glucocorticoid release
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