Pharmaceutics I

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the minimum number of phases present in a dispersed system?

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of the dispersed phase?

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it was insoluble?

Given the equation for Stoke’s law of settling below, by how much you have to increase the viscosity to offset a particle size increase of a factor of two?

Given a suspension with a fixed particle size distribution, what would be true if each powder particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of dispersion medium)?

The primary mechanism of altering dispersion medium properties is modification of:

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

An advantage of a shear thinning formulation includes:

Under what conditions would you compound a suspension using benzyl alcohol or propylene glycol for preemies?

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form. Why is it prudent to determine if a liquid dosage form is also commercially available?

Select the choices that correctly fill the blanks in the following statement: the three minimum requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically unstable?

Patients should virtually never be instructed to store an emulsion dosage form:

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

A magma is a:

In a colloidal dispersion the particle size is:

Which of following is FALSE in case of gel formulation exhibiting syneresis?

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Which of following if true of aerosol used to provide an airborne mist?

A properly prepared pharmaceutical suspension should settle slowly and should readily re dispersed upon gentle shaking on the container

Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?

Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?

Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?

When you decrease the particle size of disperse phase by factor of 10, then the settling velocity will decrease by a factor of:

What is a primary reason to formulate the powders for suspension?