8192281
Beschreibung
Quiz von Idont Evencare, aktualisiert more than 1 year ago
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Erstellt von Idont Evencare
vor mehr als 7 Jahre
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Frage 1
Frage
Melanocytes are
Antworten
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located in epidermis
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located in dermis
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originated from the neural crest
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originated from adipoblasts
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dendritic cells
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pseudo-unipolar cells
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place of melanin anabolism
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place of melanin catabolism
Frage 2
Frage
Which of the following is the correct pathway of melanin synthesis?
Antworten
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Tyrosine (oxidaton by tyrosinase) --> di-hydroxy phenylalanine (oxidation by tyrosinase) --> melanin
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Tyrosine (oxidaton by tyrosinase) --> di-hydroxy methylmelanin (oxidation by tyrosinase) --> melanin
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Tyrosinase (oxidaton by tyrosine) --> di-hydroxy methyllalanine (reduction by tyrosine) --> melanin
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Di-hydroxy methylalanine (oxidaton by tyrosinase) --> tyrosine (reduction by tyrosinase) --> melanin
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Di-hydroxy methylalanine (oxidaton by tyrosine) --> tyrosinase (reduction by tyrosine) --> melanin
Frage 3
Frage
What are the three most common types of skin cancer?
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malignant melanoma
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basal cell melanoma
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malignant basal keratoses
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basal cell carcinoma
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squamous cell carcinoma
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merkel cell carcinoma
Frage 4
Frage
Which of the following is the commonest skin cancer
Antworten
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basal cell carcinoma
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squamous cell carcinoma
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malignant melanoma
Frage 5
Frage
Which of the following is the easiest skin cancer to treat
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squamous cell carcinoma
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basal cell carcinoma
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malignant melanoma
Frage 6
Frage
Squamous cell carcinoma rarely metastasises.
Antworten
- True
- False
Frage 7
Frage
Melanoma is the most common cancer in elderly
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- True
- False
Frage 8
Frage
Melanoma metastises
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very early
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only if untreated
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to most body sites
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almost exclusively to joints and liver and heart only
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commonly to lymph nodes
Frage 9
Frage
Melannoma is the moset rapidly increasing common cancer type
Antworten
- True
- False
Frage 10
Frage
What are the predisposing factors for melanoma?
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exposure to sun
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alcohol abuse
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DNA repair mechanism mutations
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P16 gene
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CDKN2A
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PK20 gene
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CD150C
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dysplastic naevi
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skin colour
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number of pre-existing moles
Frage 11
Frage
The types of melanoma are
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Nodular Melanoma
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Acral lentiginous melanoma
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Lentigo maligna melanoma
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Superficial spreading
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Lego malaria melanoma
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Occular mesenchymous melanoma
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Cranial melanoma
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Chronic hepatocyte melanoma
Frage 12
Frage
ABCD rule in melanoma diagnosis stands for
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A – aplasticity B – Border irregularity C – colour D – distance
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A – asymmetry B – Border irregularity C – colour D – diameter
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A – asymmetry B – Border integrity C – change in size D – distance
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A – aplasticity B – basal cell symetry C – colour D – diameter
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A – aplasticity B – Border integrity C – change in size D – distance
Frage 13
Frage
Initial diagnosis of melanoma is performed by
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examination using bright light and magnification
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histology using ziehl-neelsen stain
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biopsy followed by ELISA
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ELISA
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biopsy followed by PCR
Frage 14
Frage
Common antibodies used in diagnosis of melanoma by immunohistochemistry include
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Melan M
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Melan A
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HMB 45
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S 100
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CDK 150
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JK 480
Frage 15
Frage
Diagnosis of melanoma is performed by
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+/- immmunohistochemistry
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+/- immunocytochemistry
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special stain histology
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H/E stain histology
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ELISA
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laparoscopy
Frage 16
Frage
Melanin does not always have to be present in melanoma
Antworten
- True
- False
Frage 17
Frage
In histological examination of melanoma, which if the following are typically observed?
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Prominent nucleoli
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Missing nucleoi
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Irregular nucleoi
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Popcorn cells
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Reed-Strenberg cells
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Large cells
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Small cells
Frage 18
Frage
Special stains are the most common diagnostic tool in melanomas
Antworten
- True
- False
Frage 19
Frage
Melanin is a
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big strong cookie booboo
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strong reducing agent
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strong oxidising agent
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reactively inert molecule
Frage 20
Frage
Special stains can be used for the diagnosis of amelanotic melanomas
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- True
- False
Frage 21
Frage
Immunohistochemistry can be used for the diagnosis of amelanotic melanomas
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- True
- False
Frage 22
Frage
Immunocytochemistry is used in diagnosis of melanoma in
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Difficult cases
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Metastasis
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Micro invasion
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None of the above
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All of the above
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Reed-Sternberg melanoma
Frage 23
Frage
The target protein for S100 is [blank_start]not specific for melanoma[blank_end], HMB45 is [blank_start]sometimes absent from melanomas[blank_end] and Melan A is sometimes found in [blank_start]non-melanoma tumours[blank_end].
Antworten
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not specific for melanoma
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sometimes absent from melanomas
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non-melanoma tumours
Frage 24
Frage
Clinical staging is based on
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histological staging of primary tumour
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histological staining of metastasis
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lymph node involvement
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basal cell involvement
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metastases
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age of the patient
Frage 25
Frage
Breslow [blank_start]depth[blank_end] measures the [blank_start]thickness of tumour[blank_end] whereas Clark [blank_start]levels[blank_end] measure the [blank_start]depth of invasion[blank_end]. Breslow method is [blank_start]more accurate[blank_end] than Clark method.
Antworten
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depth
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thickness of tumour
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levels
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depth of invasion
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more accurate
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less accurate
Frage 26
Frage
Clinical staging does NOT rely on the histological measurement of
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Ulceration
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Lymphoid infiltration
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Mitotic activity
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Vascular ivasion
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Dendritic necrosis
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Microscopic satellites
Frage 27
Frage
Treatment of melanoma is the same regardless of the stage
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- True
- False
Frage 28
Frage
Treatment of melanoma can include the removal of
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all metastases
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sentinel lymph node/s
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primary tumour, minimum 5mm
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primary tumour, minimum 2mm
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all moles
Frage 29
Frage
Biological therapy of melanoma often consists of
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BRAF inhibitor drug regimes
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Interleukin alpha inhibitor drug regime
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Low salt and fat intake diet
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Broad spectrum drugs
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Localised irradiation
Frage 30
Frage
BRAF 600 gene is found in about half the melanoma patients
Antworten
- True
- False
Frage 31
Frage
Punch skin biopsy is the only method of obtaining histological tissue for diagnosis of melanoma.
Antworten
- True
- False
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