10547034
Beschreibung
Karteikarten von Luis Miguel Barajas Castañeda, aktualisiert more than 1 year ago
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Erstellt von Luis Miguel Barajas Castañeda
vor etwa 7 Jahre
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| Frage | Antworten |
| CD1 | Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias. Non-peptide antigen presentation to T-cell receptors on NKT cells, marks |
| CD1b | Cortical thymocytes, Langerhans cells and dendritic cells. Non peptide antigen presentation to T-cell receptors on NKT cells. |
| CD1c | Cortical thymocytes, Langerhans cells, dendritic cells and B-cell subsets. Non peptide antigen presentation to T-cell receptors on NKT cells. |
| CD1d R3G1 | Intestinal epithelial cells, B-cell subsets, cortical thymocytes, dendritic cells and certain T-cell leukemias. Non peptide antigen presentation to T-cell receptors on NKT cells. |
| CD1e R2G1 | Cortical thymocytes, Langerhans cells, dendritic cells and certain T-cell leukemias. Non peptide antigen presentation. |
| CD2 SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor | Thymocytes, natural killer cells, T- and B-cells. Adhesion between T-cells and other cell types and T-cell activation. |
| CD3d T3D, OKT3 | Mature T-cells and thymocytes. T-cell activation signaling and regulation of TCR expression. |
| CD3e T3E, TCRE | Mature T-cells and thymocytes. T-cell activation signaling and regulation of TCR expression. |
| CD3g T3G | Mature T-cells and thymocytes. T-cell activation signaling and regulation of TCR expression. |
| CD4 | Thymocyte subsets, T-helper cells, regulatory T-cells, monocytes and macrophages. T-cell activation, thymic differentiation and receptor for HIV. |
| CD5 LEU1 | Thymocytes, T- and B-cell subsets and B-cell chronic lymphocytic leukemia cells. Regulates T-cell: B-cell interactions. Interacts with CD72. |
| CD6 OX52, T12, TP120 | Thymocytes, T- and B-cell subsets and neuron subsets. Thymocyte development, a potential market of T-cell activation. |
| CD7 LEU 9, GP40, TP41 | Thymocytes, T-cells, natural killer cells and pluripotent hematopoietic stem cells. T-cell costimulation. Interacts with SECTM1. |
| CD8a MAL | Thymocyte subsets, cytotoxic T-cells, natural killer cells and dendritic cells subsets. Co-receptor for MHC class 1 molecules. |
| CD8b CD8B1 | Thymocyte subsets and cytotoxic T-cells. Co-receptor for MHC class 1 molecules. |
| CD9 P24, 5H9 antigen, MIC3, TSPAN29, GIG2 | Platelets, pre-B-cells, eosinophils, basophils, activated T-cells, endothelial cells and epithelial cells. Cell adhesion and migration, platelet activation and aggregation. |
| CD10 Neprilysin, CALLA, SFE, MME, EPN | B- and T-cell precursors, fibroblasts, neurons and bone marrow stromal cells. Peptidase, regulates B-cell growth. |
| CD11a Integrin alpha-L, LFA-1A, ITGAL | Leukocytes, lymphocytes, granulocytes, monocytes and macrophages. Intracellular adhesion and costimulation. |
| CD11b Integrin alpha-M, CR3A, ITGAM | Granulocytes, monocytes, natural killer cells, T- and B-cells and dendritic cells. Cell adhesion, apoptosis and chemotaxis. |
| CD11c Integrin alpha-X, Leu M5, ITGAX | Monocytes, macrophages, granulocytes, T- and B-cell subsets. Cell adhesion. |
| CD11d Integrin-alpha-D, ADB2, ITGAD | Myelomonocytic cells, peripheral blood leukocyte subsets and tissue-specialized cells. Receptor for ICAM3 and VCAM1. May play a role in atherosclerotic process and phagocytosis of blood-borne pathogens. |
| CD13 Aminopeptidase N, ANPEP, APN, PEPN | Granulocytes, monocytes (+ precursors), endothelial cells and epithelial cells. Zinc binding metalloproteinase. |
| CD14 | Monocytes, macrophages (myelomonocytic cells), Langerhans cells and granulocytes. Receptor for complex of LPS and LBP. |
| CD15 3-FAL, ELAM 1 ligand, fucosyltransferase, Leu M1 | Granulocytes, monocytes, neutrophils and eosinophils. Cell adhesion. Mediates phagocytosis and chemotaxis. |
| CD16a Fc-gamma RIII-alpha, FCGR3A, FCG3, FCGR3, IGFR3 | Neutrophils, natural killer cells and macrophages. Low affinity Fc receptor. Mediates phagocytosis and ADCC. |
| CD16b Fc-gamma RIII-beta, FCGR3B, FCG3, FCGR3, IGFR3 | Neutrophils and stimulated eosinophils. Low affinity Fc receptor. |
| CD17 Lactosylceramide | Monocytes, platelets, B-cell subsets, granulocytes, dendritic cells, T-cells, platelets, neutrophils and thrombocytes. Lactocyl ceramide. Cell surface glycosphingolipid. May play a role in bacterial phagocytosis. |
| CD18 Integrin beta-2, ITGB2, MFI7 | Leukocytes. Forms the beta 2 chain of CD11a-c, cell adhesion. |
| CD19 B-lymphocyte surface antigen B4, T-cell surface antigen Leu-12 | B-cells (but not plasma cells) and follicular dendritic cells. Regulates B-cell development, activation and differentiation. Signal transduction. |
| CD20 B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, MS4A1 | T- and B-cell subsets. B-cell activation and proliferation. |
| CD21 Complement receptor type 2, CR2, C3DR, Complement C3d receptor, Epstein-Barr virus receptor | Mature B-cells, follicular dendritic cells and T-cell subsets. Signal transduction. Receptor for complement components C3Dd and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. |
| CD22 SIGLEC2, BL-CAM, T-cell surface antigen Leu-14 | Mature B-cells. B-cell adhesion and signal transduction. |
| CD23 Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Fc epsilon RII, FCER2, CLEC4J | Mature B-cells, activated macrophages, eosinophils, follicular dendritic cells and platelets. Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. |
| CD24 Nectadrin | B-cells, granulocytes, epithelial cells and monocytes. Regulation of B-cell proliferation and differentiation. |
| CD25 Interleukin-2 receptor subunit alpha, IL2RA, TAC antigen | Activated T- and B-cells, some thymocytes, pre B-cells, regulatory T-cells, and oligodendrocytes. Receptor for IL2. |
| CD26 Dipeptidyl peptidase 4, DPP4 , ADABP, ADCP2 | Mature thymocytes, T-cells (upregulated on activation), activated B-cells, natural killer cells, epithelial cells and macrophages. Exoprotease. HIV pathogenesis. |
| CD27 TNF receptor superfamily member 7, TNFRSF 7, CD27L receptor, T14 | T-cells, medullary thymocytes, B-cell subsets and natural killer cells. Costimulation of B- and T-cell activation. |
| CD28 TP44 | Most T-cells, thymocytes, plasma cells, natural killer cells and activated B-cells. Costimulation of T-cells. Induces T-cell activation and survival, interleukin-2 production, T-helper type 2 cell development and clonal expansion. |
| CD29 Integrin beta-1, ITGB1, Fibronectin receptor subunit beta, FNRB | Leukocytes. Interacts with CD49a in VLA-1 integrin. Lymphocyte and endotelial adhesion, lymphocyte trafficking and transvascular migration. Promotes or inhibits apoptosis (depending on stimulus). |
| CD30 TNF receptor superfamily member 8, TNFRSF8, Ki-1 antigen | Activated T- and B-cells, monocytes, activated natural killer cells and Reed-Sternberg cells. Regulates lymphocyte proliferation and cell death. Has a critical role in the pathophysiology of Hodgkin’s disease and other CD30+ lymphomas. |
| CD31 Platelet endothelial cell adhesión molecule, PECAM1 | Monocytes, platelets, granulocytes, endothelial cells, lymphocyte subsets and epithelial cells. Cell adhesion. Plays a key role in leukocyte trafficking across endothelium |
| CD32 Fc gamma RII, FCGR2A, FCGR2B | B-cells, monocytes, granulocytes, platelets and endothelial cells. Regulation of B-cell function. Induces phagocytosis and mediator release. |
| CD33 Sialic acid-binding Ig-like lectin 3, SIGLEC3 | Monocytes, granulocytes, mast cells and myeloid progenitors. Lectin activity and adhesion. A receptor that inhibits the proliferation of normal and leukemic myeloid cells. |
| CD34 | Hematopoietic stem cells and progenitors and capillary endothelial cells. Cell adhesion (via L-selectin). Possible role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracelular matrix or directly to stromal cells. |
| CD35 Complement receptor type 1, C3b/C4b receptor | Erythrocytes, B-cells, monocytes, neutrophils, eosinophils, follicular dendritic cells and T-cell subsets. Receptor for complement components C3b and C4b. Mediates adhesión and phagocytosis. |
| CD36 Platelet glycoprotein 4, Fatty acid translocase, Glycoprotein IIIb GP3B, GP4 | Platelets, monocytes, macrophages, endothelial cells and thyroid precursors. Scavenger receptor preferentially found within lipid rafts. Mediates adhesion and phagocytosis. |
| CD37 Tetraspanin 26, TSPAN26 | Mature B-cells and myeloid cells. Low level of expression in T-cells, granulocytes and monocytes. Signal transduction. Regulates T-cell proliferation. |
| CD38 ADP ribosyl cyclase 1 | Variable expression levels on most hematopoietic and some non-hematopoietic cells. High levels on plasma cells, early T- and B-cells, activated T-cells and germinal centre B-cells. Regulates cell activation, proliferation and adhesion. |
| CD39 NTPDase 1, ENTPD1 | Macrophages, Langerhans cells, dendritic cells, activated B-cells, natural killer cells and microglial cells. B-cell adhesion. Protects activated cells from lysis. |
| CD40 TNF receptor superfamily member 5, TNFRSF5 | B-cells, monocytes, macrophages, follicular dendritic cells, endothelial cells, fibroblasts and keratinocytes. Costimulation of B-cell growth. Differentiation and isotype switching. |
| CD41 Integrin alpha-IIb, GPalpha IIb, ITGA2B, GP2B | Platelets and megakaryocytes. Platelet activation and aggregation. |
| CD42a Platelet glycoprotein IX, GP9 | Platelets and megakaryocytes. Platelet adhesion and aggregation. Amplifies platelet response to thrombin |
| CD42b Platelet glycoprotein Ib alpha chain, GP1BA | Platelets and megakaryocytes. Platelet adhesion and aggregation. |
| CD42c Platelet glycoprotein Ib beta chain, GP1BB | Platelets and megakaryocytes. Platelet adhesion and aggregation. |
| CD42d Platelet glycoprotein V, GP5 | Platelets and megakaryocytes. Platelet adhesion and aggregation. |
| CD43 Leukosialin, Galactoglycoprotein, Leukocyte sialoglycoprotein, SPN | Leukocytes (except resting B-cells). Low expression in platelets. Anti-adhesion. Binds CD45 to mediate adhesion. |
| CD44 Epican, HUTCH-I, LHR, PGP-1, ECMR-III | Most lymphohematopoietic cells. Leukocyte rolling, homing and aggregation. Adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. Important in epithelial cell adhesion (cell-cell and cell-matrix) to hyaluronate in basement membranes, and maintaining polar orientation of cells. |
| CD45 Leukocyte common antigen, L-CA, PTPRC | Hematopoietic cells (not erythrocytes and platelets). Critical for B- and T-cell receptor mediated activation. Also required for thymic selection. |
| CD45RA | B- and naïve T-cell subsets, monocytes and medullary thymocytes. Critical for B- and T-cell receptor mediated activation. Also required for thymic selection. |
| CD45RB | T-cell subsets, B-cells, monocytes, macrophages, granulocytes, dendritic cells and natural killer cells. Critical for B- and T-cell receptor mediated activation. |
| CD45RC | B-cells, natural killer cells, CD8+ T-cells, CD4+ T-cell subsets, medullary thymocytes, monocytes and dendritic cells. Critical for B- and T-cell receptor mediated activation. |
| CD45RO | Activated T-cell subsets, memory B- and T-cell subsets, monocytes, macrophages, granulocytes, cortical thymocytes and dendritic cell subsets. |
| CD46 Membrane cofactor protein, TLX, MCP | Ubiquitous except erythrocytes. Co-factor for factor 1 proteolytic cleavage of C3b and C4b. Sets protective barrier threshold against inappropriate complement activation. |
| CD47 Integrin associated protein, MER6 | Hematopoietic cells, epithelial cells, endothelial cells and mesechymal cells. Adhesion. A marker of self which binds to SIRP alpha inhibitor receptor on macro and dendritic cells to inhibit phagocytosis. Regulates chemotaxis and activation of leukocytes. |
| CD48 BLAST1, BCM1 | Leukocytes. Cell adhesion and T-cell costimulation. |
| CD49a Integrin alpha-1, VLA-1, ITGA1 | Activated T-cells, monocytes, melanoma cells and endothelial cells. Adhesion and embryo development. |
| CD49b Integrin alpha-2, VLA-2 subunit alpha, ITGA2 | Platelets, B-cells, monocytes, activated T-cells, epithelial cells, endothelial cells, natural killer cell subsets and megakaryocytes. Adhesion and platelet aggregation. Receptor for echovirus 1. |
| CD49c Integrin alpha-3, VLA-3 subunit alpha, ITGA3 | Most adhesion cell lines. Low expression on B- and T-cells. Adhesion and signal transduction. |
| CD49d Integrin alpha-4, VLA-4 subunit alpha, ITGA4 | B- and T-cells, thymocytes, monocytes, eosinophils, basophils, natural killer cells, mast cells, dendritic cells and erythroblastic precursors. Adhesion, cell migration, homing and activation. |
| CD49e Integrin alpha-5, VLA-5, ITGA5 | Thymocytes, T-cells, monocytes, platelets, early and activated B-cells, endothelial cells and epithelial cells. Adhesion, regulation of cell survival and apoptosis. |
| CD49f Integrin alpha-6, VLA-6, ITGA6 | Memory B-cells, T-cells, thymocytes, monocytes, platelets, megakaryocytes, epithelial cells, endothelial cells and cytotrophoblasts. Embryogenesis, adhesion and cell migration. |
| CD50 ICAM3 | Leukocytes, thymocytes, Langerhans cells, endothelial cells, B- and T-cells, granulocytes and monocytes. Adhesion and costimulation. |
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