Lecture 22 Limbic System

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534 Neuroanatomy Karteikarten am Lecture 22 Limbic System, erstellt von Mia Li am 03/12/2017.
Mia Li
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Mia Li
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Frage Antworten
Key functions of limbic system: 1. olfaction 2. emotions and drives 3. homeostasis 4. memory
T/F: All cortex of limbic system are neocortex. F. Some are allocortex, some are archecortex
Septal nuclei is excited by the transmitters. cholinergic
The ventral tegmental area is regulated by the _______ transmitters. dompaminergic
The locus ceruleus is regulated by the _______ transmitters. noradrenergic
The raphe nuclei are regulated by the _________ transmitters. serotonergic
The medial cortical region of limbic system is called the ________. Association cortex
T/F: Most association fibers of limbic system run in one direction. F. Usually both directions.
Name the structure that serves the following function: 1. smell 2. emotion and drives 3. establishing new memories 4. homeostasis 1. smell: olfactory cortex 2. emotion and drives: amygdala 3. establishing new memories: hippocampal formation 4. homeostasis: hypothalamus
The limbic system is a collection of cortical gyri buried within the __________. anteromedial telencephalon
Key gyri in limbic system: 1. cingulate 2. orbital frontal 3. rectus 4. parahippocampal
Hyppocampal formation are located (superficial/deep) to the parahippocampal gyri. Deep
Anterior to the hippocampal formation is the _________. Amygdala
Structure responsible for: 1. conscious detection of smell 2. ordor discrimination 1. primary olfactory cortex 2. orbitofrontal olfactory area
the _________ of the parahippocampal gyrus is an important target for the emotional and memory aspect of smell. entorhinal cortex
The ________ forms explicit memory. hippocampal formation
What are considered as 'explicit memory'? 1. conscious cognitive 2. verbal-based learning processes
Location of hippocampal formation deep to entorhinal cortex
Three parts of the hippocampal formation 1. dentate gyrus 2. hippocampus 3. subiculum
T/F: All hippocampal formation are neocortex F. Archicortex.
Which three layers of cells are in the hippocampal formation? 1. molecular layer 2. pyramidal or granular layer 3. polymorphic layer
The _______ and _______ folds twice. dentate gyrus hippocampus
The hippocampus forms the ___ of lateral ventricle in the _____ horn. floor (medial wall) inferior horn
The parahippocampal gyrus ends up on the _____ surface of the medial temporal cortex, around the _______. inferior around midbrain
Uncus is _______ with mammilary bodies. parallel
Many neocortical areas project to the entorhinal cortex, which projects to the _______ gyrus via _______. dentate gyrus via the perforant pathway
The perforant pathway (or indirect perforant pathway) is important for _________ long term synaptic plasticity [long-term potentiation (LTP)]
3 layers of dentate gyrus from outer to inner 1. molecular (outer) 2. granular (middle) 3. polymorphic (inner fiber tracts)
The perforant pathway from entorhinal input synapse with the ____ cells in the dentate gyrus granule cells
Granule cell axons ( _______ fibers) from dentate gyrus project to the _____ and synapse on _____ pyramidal cells. Granule cell axons [dentate fibers] from dentate gyrus project to the [hippocampus] and synapse on [CA3] pyramidal cells.
CA3 axons are called the Schaffer collateral fibers
CA3 axons project to _____ neurons. CA1
T/F: CA3---CA1 pathway is also long-term potentiation pathway. T.
Entorhinal cortex also have direct pathway to _____ and _____ pyramidal cells in the hippocampus. This pathway is called _______. CA1 and CA3 alvear pathway (direct perforant pathway)
The direct perforant pathway leads back to _____ and ______. The subiculum and entorhinal cortex
Feedback loops run from ____ to _____ and then to _______. subiculum --- entorhinal --- association cortex
The hippocampus and subiculum also form output paths to limbic system, thalamus, and hypothalamus via ________ The fornix
Fornix is a white matter tract formed by the axons from _______ and ______ which are directed into the _____. Pyramidal CA1 and CA3 directed to the fimbria
Fibers crossing between hemispheres are called ________. It is continuous with the (anterior/posterior) fornix. hippocampal commisure continuous with anterior fornix
Non-decussating fornix fibers either 1) bend and descend behind the _____ and end up in the __________. 2) bend and direct anterior to the anterior commissure and terminate in the _________, which is related to our ______ system. 1) Behind the anterior commisure end up in the mammillary bodies 2) septal nuclei, reward system
Fornix fibers to mammillary bodies --> anterior thalamus --> anterior limb of internal capsule (thalamocortical fibers) --> cingulate gyrus This is the second feedback loop to entorhinal cortex
T/F: the fornix pathway is bi-directional. T.
Outline the Papez circuit parahippocampal entorhinal cortex --> dentate gyrus --> subiculum + hippocampus (pyramidal CA3 to CA1) --> fimbria --> fornix --> mammillary bodies --> anterior thalamus --> internal capsule --> cingulate gyrus --> back to parahippocampal gyrus
___________ has a dominant role in emotional aspect of olfaction. Amygdala
What happens to the patient if amygdala has lesion? placid, non-aggressive behavior
S/S of hyperactive amygdala rage, fear, panic
Connections the amygdala has 1. limbic cortex 2. septal nuclei 3. hypothalamus 4. brainstem autonomic pathways
What are the 3 primary pathways of the amygdala? 1. stria terminalis 2. ventral amygdalofugal 3. medial forebrain bundle
position of stria terminalis medial along caudate similar path as fornix form amygdala to ventromedial hypothalamus and septal nuclei
What does the stria terminalis carry? olfactory input to motivate/inhibit appetite
The ventral amygdalofugal pathway projects to ______, _____ and _____ to support emotion, drive, and cognitive functions, and to ______ to impact homeostasis and arousal. septal, basal forebrain, and ventral striatum also to hypothalamus
The median forebrain bundle carries ________, _____ and ______ fibers to nuclei under ________ control. septal, hypothalamic and brainstem fibers to autonomic nuclei (vagus, solitary, periaqueductal gray, reticular)
unfinished start from major neurotransmitter systems
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