Enzyme Inhibition

Beschreibung

A level Biology (2.1.4 Enzymes) Karteikarten am Enzyme Inhibition, erstellt von Yinka F am 27/01/2018.
Yinka F
Karteikarten von Yinka F, aktualisiert more than 1 year ago
Yinka F
Erstellt von Yinka F vor fast 7 Jahre
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Zusammenfassung der Ressource

Frage Antworten
What are the 2 types of enzyme inhibitors? Competitive inhibitor Non-competitive inhibitor
How do competitive inhibitors work? Competitive inhibitors have a similar shape to the substrates They compete with substrates to bind to the active site but no reaction takes place; they block the active site
What happens to competitive inhibition when the concentration of substrates increases? The effect is reversed and the substrate will out-compete the inhibitors
How do non-competitive inhibitors work? Non-competitive inhibitors bind to the enzyme at the allosteric site. This causes the active site to change shape so the substrate can no longer bind to it.
What happens to non-competitive inhibition when the concentration of substrates increases? Increasing the substrate concentration will have NO EFFECT. This is because non-competitive inhibitors do not "compete" with the substrates as they have a different shape
Enzymes inhibitors can either be reversible or non-reversible. What does this depend on? The strength of the bonds between the enzyme and the inhibitor
How do covalent bonds between the enzyme and inhibitor affect inhibition? Strong covalent bonds = inhibitor cannot be easily removed and inhibition is irreversible
How do hydrogen/ionic bonds between the enzyme and inhibitor affect inhibition? Weaker hydrogen/ionic bonds = inhibitor can be removed and inhibition is reversible
What is a metabolic pathway? A series of connected metabolic reactions. Each reaction is catalysed by a different enzyme
How are metabolic pathways regulated? By end-product inhibition - many enzymes are inhibited by the product of the reaction they catalyse
What is end-product inhibition? When the final product in a metabolic pathway inhibits an enzyme that acts earlier on in the pathway
Complete the sentences: End-product inhibition is ____________, so when the level of the end-product drops, _________drops and so more product can be made. This is a good way of ___________ the pathway and controlling the amount of ______-___________ that gets made. This is a ___________ ___________ mechanism. End-product inhibition is REVERSIBLE, so when the level of the end-product drops, INHIBITION drops and so more product can be made. This is a good way of REGULATING the pathway and controlling the amount of END-PRODUCT that gets made. This is a NEGATIVE FEEDBACK mechanism.
What do metabolic poisons do? Metabolic poisons interfere with metabolic reactions (reactions that occur in cells), causing damage, illness or death
Give examples of metabolic poisons Cyanide = non-competitive, irreversible inhibitor of cytochrome c oxidase (enzyme that catalyses respiration) Arsenic = non-competitive inhibitor of pyruvate dehydrogenase (enzyme that catalyses respiration) Malonate = competitive inhibitor of succinate dehydrogenase (catalyses respiration)
TRUE OR FALSE: Some medicinal drugs are enzyme inhibitors TRUE
Name examples of medicinal drugs which act as enzyme inhibitors Aspirin ATPase inhibitors ACE inhibitors Protease inhibitors Nucleoside reverse transcriptase inhibitors
How does aspirin act as an enzyme inhibitor? Aspirin binds to enzymes that catalyse the formation of prostaglandins
How do ATPase inhibitors act as enzyme inhibitors? ATPase inhibitors inhibit sodium-potassium pumps in the cell membranes of heart-muscle cells, allowing more Ca²⁺ to enter cells (increases muscle contraction)
How do ACE inhibitors act as enzyme inhibitors? ACE inhibitors inhibit angiotensin converting enzyme (ACE) to lower blood pressure and treat heart failure
How do protease inhibitors act as enzyme inhibitors? Protease inhibitors are used to treat some viral infections. They prevent replication of the virus particles within host cells by inhibiting protease enzymes so viral coats cannot be made
How do nucleoside reverse transcriptase inhibitors act as enzyme inhibitors? Nucleoside reverse transcriptase inhibitors are used to treat to treat HIV by inhibiting reverse transcriptase (catalyses replication of viral DNA)
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