Toxicology

Beschreibung

Karteikarten am Toxicology, erstellt von Fatin Nabilah Roslaile am 24/05/2018.
Fatin Nabilah Roslaile
Karteikarten von Fatin Nabilah Roslaile, aktualisiert more than 1 year ago
Fatin Nabilah Roslaile
Erstellt von Fatin Nabilah Roslaile vor mehr als 6 Jahre
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Zusammenfassung der Ressource

Frage Antworten
Overpredictions for initial concentrations inaccurate history of dose innacurate time interval
Overprediction for initial concentrations -Early sampling with minimal time for product dissolution and absorption to occur -low absorption (positive outcomes from gastric emptying events) -delayed/incomplete absorption (poorly water soluble products)
Underpredictions for initial concentrations -Inaccurate history of dose (historical data low dose) -inaccurate time interval (historical data too long) -alterations in absorption (dose dumping of sustained release dosage forms) -early sampling during distribution phase, but Cp is calculated using post-distribution Vd
Underpredictions for subsequent concentrations -alterations in absorption (dose-dumping of sustained release dosage forms) -Bezoar dissolution endogenous metabolism and/or elimination is slower than known population values -calculated patient-specific Ke was predistribution not during true elimination -ineffective decontamination or elimination-enhancement therapies, and/or unaccounted new administration
How to reduce toxicity? 1. prevent absorption 2. Antidotes 3. Enhanced elimination
Examples of Preventing absorption Emesis, gastric lavage, activated charcoal, whole bowel irrigation
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