26899132
Beschreibung
Karteikarten von Majd Fawaz, aktualisiert more than 1 year ago
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Erstellt von Majd Fawaz
vor etwa 4 Jahre
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| Frage | Antworten |
| State the effects of ACh on - Vasculature - Eye - Salivary and Lacrimal Glands - Bronchi - Heart - GI Tract - Urinary Blander - Sweat Glands - Male Reproductive Tract - Uterus | - Vasculature: Indirect Vasodilation (NO) - Eye: Miosis+Accommodation (Near) - Salivary Glands: Inc. Watery Secretions - Bronchi: Constrition - Heart: Bradycardia+Dec. Conductivity (AV node) - GI Tract: Inc. Tone, Secretions+Relax Sphincter - Urinary Blander: Detrusor Muscle Contraction+Relax Sphincter - Sweat Glands: Diaphorisis - Male Reproductive Tract: Erection - Uterus: Variable |
| - Muscarine - Isolated from Amanita Muscaria (Mushroom) - Epi-Allo-Epiallo Isomers | |
| - Nicotine | |
| - Acetylcholine - Non Selective Cholinergic Agonist - pH Independent - Not Used Clinically | |
| - Methacholine - Muscarinic Agonist - (+) is Equipotent to ACh - More Resistance to AChE | |
| - Carbachol - Similar Potency to ACh - Non Selective - More Resistance to AChE | |
| - Bethanechol - Potent Selective Muscarinic Agonist - (+) > (-) - More Resistance to AChE | |
| - Choline Ethyl Ether - Muscarinic Agonist - Exception to the SAR | |
| - Pilocarpine - Alkaloid (Pilocarpus Jaborandi) - Potant Muscarinic Agonist - Hydrolisis and Epimerization Give 2 Inactive Products (Pilocarpic Acid, Isopilocarpine) | |
| - Physostigmine - Reversible AChEI - Alkaloid (Physostigma venenosum/Calanbar Bean) - Exhibits High Affinity to AChE Compared to Carbachol - Used To Treat Glaucoma and Overdoses of Anticholinergics - Light Sensitive - Undegoes Hydrolysis in Aqeuous Sol. | |
| - Eseroline - Inactive product of Physostigmine Degradation | |
| - Rubreserine - Inactive product of Physostigmine Degradation - Red in Color - Used to Identify Shelf Life of Physostigmine | |
| - Neostigmine - Reversible AChEI – Synthetic compounds – Ionized – Indicated for Myastenia Gravis | |
| - Pyridostigmine - Reversible AChEI – Synthetic compounds – Ionized – Indicated for Myastenia Gravis | |
| - Rivastigmine - Reversible AChEI - Used for Alzheimer’s Disease | |
| - Carbaryl - Reversible AChEI | |
| - Donepezil - Reversible AChEI - Used for Alzheimer’s Disease - Lacks Hepatotoxicity | |
| - Tacrine - Reversible AChEI - Used for Alzheimer’s Disease - Reported Hepatotoxicity | |
| - Edrophonium - Reversible AChEI - Class: Bisquaternery amonium - Myastenia Graves VS Cholinergic Criss - Rapid Renal Excretion - No Medicinal Use | |
| - Demecarium bromide - Reversible AChEI - Class: Bisquaternery amonium | |
| - Galantamine - Reversible AChEI - Class: Bisquaternery amonium | |
| - Ambenonium Cholride - Reversible AChEI - Class: Bisquaternery amonium | |
| - Sarin - Irreversible AChEI (Organophosphate) - Very Lipophilic - Deadly Nerve Gas - Faster Aging | |
| - Diisopropylflourophosphate (DFP) - Irreversible AChEI - Very Lipophilic - Deadly Nerve Gas | |
| - Echothiophate iodide - Irreversible AChEI - Very Lipophilic - Used as Eye Drops for Glaucoma | |
| - Malathion - Irreversible AChEI - Very Lipophilic - Poor AChE Inhibitor (Malathionic Acid as well) | |
| - Malaoxone - x10000 > inhibition than Malathion | |
| - Parathion - Irreversible AChEI - Very Lipophilic - Poor AChE Inhibitor | |
| - Paraoxon - Irreversible AChEI - Very Lipophilic - Good AChE Inhibitor | |
| - Schradan - Irreversible AChEI - Very Lipophilic | |
| - Dichlofenthion - Irreversible AChEI - Very Lipophilic | |
| - Obidoxime - Organophosphate Antidote (Give within 30 min) - Ionized (Periphery) - Should be given in combination | |
| - Diacetyl monoxime (DAM) - Organophosphate Antidote (Give within 30 min) - Centrally - Should be given in combination | |
| - 2-Pyridyl Acetyl Monooxime (2-PAM) - Organophosphate Antidote (Give within 30 min) - Ionized (Periphery) - Should be given in combination | |
| - Atropine - Nonselective Muscarinic Antagonist - Alkaloid (Atropa Belladonna/Datura Stramonium) | |
| - Scopolamin - Nonselective Muscarinic Antagonist - Alkaloid (Hyoscyamus niger) | |
| - Glycopyrrolate - Competitive Antagonist - Antispasmodic Effects - Produce mydriasis - Antisecretory - Main Use: Anti-Ulcer Othe Use: Anti-Diarrhea, Anti-Asthmatic | |
| - Propantheline - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Main Use: Anti-Ulcer Othe Use: Anti-Diarrhea, Anti-Asthmatic | |
| - Clidinium - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Main Use: Anti-Ulcer Othe Use: Anti-Diarrhea, Anti-Asthmatic | |
| - Ipratropium - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Main Use: Anti-Asthmatic | |
| - Flavoxate - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - pH Dependent | |
| - Oxyphencyclimine - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Use: Parkinson | |
| - Procyclidine - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - pH Dependent - Central/Peripheral Effect | |
| - Trihexyphenidyl - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - pH Dependent - Central/Peripheral Effect | |
| - Benzatropine - Competitive Antagonist - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Use: Parkinson | |
| - Orphenadrine - Competitive Antagonist - Anticholinergic > Antihistaminic - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Use: Parkinson | |
| - Diphenhydramine - Competitive Antagonist - Anticholinergic < Antihistaminic - Antispasmodic Effects - Produce Mydriasis - Antisecretory - Use: Parkinson | |
| - Pirenzepine - Selective M1 antagonist - Class: 1,5 BDZ - Use: Peptic Ulcer | |
| - Telenzepine - Selective M1 antagonist - Class: 1,5 BDZ - Use: Peptic Ulcer | |
| - Hexamethonium - Ganglionic blockers - Class: Bis-quaternaryamonium - Local Effect | |
| - Trimetaphan - Ganglionic blockers - Class: Sulfonium - Local Effect | |
| - Pentolinium - Ganglionic blockers - Class: Bis-quaternaryamonium - Local Effect | |
| - Mecamylamine - Ganglionic blockers - Class: 2nd Amine - Systemic Effect | |
| - Pempidine - Ganglionic blockers - Class: 3rd Amine - Systemic Effect | |
| - Succinylcholine - DNMJ Blockers - Low DOA | |
| - Tubocurarine - NDNMJ Blockers - Use: Muscle Relaxtion | |
| - Pancuronium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Ammonium Steroids - Use: Muscle Relaxtion | |
| - Vecuronium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Ammonium Steroids - Use: Muscle Relaxtion | |
| - Pipecuronium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Ammonium Steroids - Use: Muscle Relaxtion | |
| - Rocuronium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Ammonium Steroids - Use: Muscle Relaxtion | |
| - Atracurium - Competitive Antagonists (Treatable) - CNS Effect - Given IV - Class: Benzylisoquinoline - Use: Muscle Relaxtion | |
| - Mivacurium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Benzylisoquinoline - Shortest DOA - Use: Muscle Relaxtion | |
| - Doxacurium - Competitive Antagonists (Treatable) - Lack CNS Effect - Given IV - Class: Benzylisoquinoline - Use: Muscle Relaxtion | |
| - Laudanosine |
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