epithelial tissue

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epithelial tissue
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four types of tissue -epithelium -connective tissue -muscle tissue -nervous tissue
two types of epithelium -covering epithelium ( epithelia that covers other tissues ) -glandular epithelium ( epithelia that has a secretory function )
definition of epithelium 5 - epithelial tissues are composed of cells that are tightly packed together -epithelium is formed by polarized cells, closely juxtaposed - their cohesion is insured by different adhesion junctions - they have one or more common physiological functions -rests on a basal membrane that separates it from a connective tissue
characteristics of covering epithilium 4 -formed by on or more layers of epithelial cells closely juxtaposed (sometimes with non-epithelial cells) -they rest on a connective tissue through a basal lamina -they are inervated and non-vascularized (blood vessels of the underlying connective tissue do not cross the basal lamina) - have great capacity of regeneration
what does the epithelia cover? - the surface of the body ( skin / epidermis ) -natural internal cavities : . closed cavities ( cardiovascular cavities / endothelium ) & ( serous cavities / mesothelium ) . open cavities ( airway, digestive tract, urinary tract, etc... / mucosal epithelium )
four charecteristics of the epithelial cell 1- cohesion 2- epithelial morphology ( shape ) 3- polarity 4- presence of intermediate filaments of cytokeratin in their cytoplasm
cohesion of epithelial cells it has adhesion molecules and specialized junction systems that attach the epithelial cells and mantain the cohesion between the epithelial cells and the basal lamina
epithelial morphology ( epithelial cells ) the cells have three shapes; they are either - squamous - cuboidal - columnar
presence of intermediate filaments of cytokeratin in the cytoplasm ( epithelial cells ) cytokeratins are a specifity of epithelial cells
polarity of the epithelial cells - assymetrical distribution of components of the cytoplasm - assymetrical distribution of the components of the plasma membrane ( proteins, enzymes and receptors )
the epithelial cell has three distinct domains -lateral domain -apical domain -basal domain
apical domain of the epithelial cell 3 -this domain is in contact with the exernal environment of the lumen of the cavities of the organ -it's the most specialized domain ( contains most of the protein specific for the function of the organ ) -it has membrane specializations (cilia and microvilli )
lateral domain of the epithelial cell 3 -it designates the surfaces that are apposed to neighboring cells -it contains most of the proteins required for fundemental processes common to all cells - there are anchoring and adhering junctions in this domain
basal domain of the epithelil cell 2 - it rests on the basal lamina -hemi-desmosomes and focal adhesion points are observed
basement membrane or basal lamina 3 -participates to the polarization of epithelium -plays a mechanical role by ensuring the cohesiom between the latter and the underliying connective tissue -it plays a role in the exchange and filtration process and in the control of cellular metabolism
classification of the covering epithelium 3 epithelial cells are classified according to three structural criteria - number of cell layers -shape of the cells -specialization at the apical pole
properties of covering epithelia 2 - renewal of epithelia (epithelial cells are exposed to wear and aging and a limited life span. their renewal is ensured by proliferation of stem cells or replacement cells ) - permiability of epithelia ( the basal lamina acts as a selective filter )
definition of glandular cells glandular cells are epithelial cells with secretory functions. ( the secretory products are stored in the secretory vescicles, and then released on demand )
histogenesis of glands glandular epithelia results from the differentiation of some embryonic covering epithelia that bud to form a cellular mass. this mass enters into the underlying mesenchyme, it cans then : -maintain the contact with the covering epithelium ( exocrine gland ) -become detached from the covering epithelium ( endocrine gland )
classification of glandular epithelium 3 -exocrine glandular cells -endocrine glandular cells -amphicrine glands
definition of exocrine glands glands that discharge their secretory products in the externalenvironment or in a natural cavity in continuity with the external environment
exocrine cells distinguish two poles -apical pole ( poor in cell organelles and stores the elaborated products before their secretion ) -basal pole ( rests on a basement membrane thats eparates the glandular epithelium from the connective tissue )
what are contractile myoepithelial cells they are sometimes located between the secretory cells and the basal lamina; their contraction helps in the excretion of secreted product.
classification of exocrine glands according to the number of cells 2 -unicellular ( goblet cell, they produce mucus that lubricates and protects the surfaces of systems such as the digestive tract, the respiretory tract and etc... ) -multicellular (comprise a secretory part and an excretory canal, enveloped by a stroma of connective tissue )
classification of the exocrine glands according to the excretory duct and the form of the secretory portion 4 -acinous glands ( simple cinar / compound acinar ) -tubular glands ( simpe tubular / simple branched tubular / simple coiled tubular / compound tuular ) -alveolar glands ( simple alveolar / sebaceous gland ) - mixed ( tubulo-acinar glands , tubulo alveolar glands )
classification of the exocrine gland according to the nature of the secretory product 2 -serous gland ( secretory product is an enzymes of fluid consistency ) -mucous glands ( secretory product is mucus pr mucins ) -mixed glands ( sweat glands, sebaceous glands )
description of serous cells -round nucleus -cytoplasn is dark with granulations -narrow barely visible lumen -basal pole rish in RER and mitochondria -golgi apparatus very developed -they are vesicles limited by a membrane - contains enzymes ( either active or in the form of precursors )
description of mucous cells -large -cytoplasm filled with mucigenic grains -cytoplasn is clear -nucleus is flattened and pushed back to the basal pole with the rest of the organelles -wide and irregular lumen
modes of excretion 3 -merocrine mode -apocrine mode -halocrine mode
description of merocrine mode -most common -the cells produce secretions and they reject them externally by exocytosis -the cell integrity being respected
description of apocrine mode -the secretory product is gradually accumulated at the apical pole -the superficial portion of the cell is detached in the form of a large vacuole -the cell integrity being respected
description of holocrine mode - the secretory product complety fills the cytoplasm the cell then undergoes degeneration which results in the rupture of its membrane - release of accumulated product
definition of endocrine glands an endocrine glandular cell is capable of synthesizing, storing and secreting into the internal medium via the blood stream without an excretory duct, a substance called hormone (chemical messenger) will act on receptors of target cells.
classification of endocrine glands according to the morphology 3 -vesicular glands (vesicles or spherical follicles between nnective tissues and vessels) -reticular glands (the glandular cells form cords with separated by fine connective tissue that are crossed by vessels) -diffuse glands (either grouped into islets or scattered in an epithelium)
classificaton of the endocrine clands according to the type of hormone secreted 4 -steroid secreting endocrine cells -thyroid hormone secreting cells -peptides secreting endocrine cells -amino acids derivative endocrine cells
classification of the endocrine glands according to the mode of action of the receptor -steroid and thyroid act on an intracytoplasmic or intranuclear receptor -peptides and biogenic amines bind on a membrane receptor that will act on a metabolism of the cell via a second messanger
definition of amphicrine glands glands that are both exocrine for some products and endocrine for others
classification of amphicrine glands -homotypic amphicrine glands ( formed by a sinlge type of both endo and exo cells ) -heterotypic amphicrine glands (two type of cells are found in the parenchyma, some are exo and others and endo)
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